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Showing 25 / 20086 · page 29/804
Vesicle-mediated drug resistance of Candida albicans biofilm
US · IL NIH · grant
Project Summary Candida commonly adhere to medical devices, flourishing as a biofilm. A clinical hallmark of biofilm infection is profound antifungal resistance. As effective therapies are not available for these life-threatening infections…
Posted May 21, 2026
High-speed, real-time feedback-driven single particle tracking with concurrent smFRET
US · IL NIH · grant
PROJECT SUMMARY: The goal of this project is to establish proof-of-concept for a new high speed, Real-Time Feedback-Driven Single Particle Tracking (RT-FD-SPT) fluorescence microscope with concurrent spectroscopic readout. The project is mot…
Posted May 21, 2026
Project 1: Mechanisms, Dynamics, and Prediction of Heteroresistance
US · IL NIH · grant
ABSTRACT Understanding antibiotic resistance mechanisms is critical to designing novel approaches and therapeutics to combat resistant bacteria. Heteroresistance (HR) is a bacterial phenotype in which an isolate contains a subpopulation of …
Posted May 21, 2026
Characterizing the Quality of Evidence-based Prescribing for Hospitalized Veterans
US Veterans Affairs · grant
Significance to VA: Each year, hundreds of thousands of Veterans are hospitalized for new presentations and acute exacerbations of complex chronic conditions, such as cardiovascular, pulmonary, neurologic, and substance use disorders. For e…
Posted May 21, 2026
Optimizing prescribing decisions for hospitalized older adults with chronic conditions
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Over 7 million adults ages 65 and older are hospitalized in the US annually, of whom two-thirds have multiple chronic conditions. Older adults are often discharged with changes to medications for chronic conditions,…
Posted May 21, 2026
Peaks to genes: Fine mapping of QTLs and functional analysis
US · IL NIH · grant
PROJECT SUMMARY Linkage mapping using genetic crosses results in identification of quantitative trait locus (QTL) regions that may contain tens to hundreds of genes. Identification of the causative genes therefore requires careful prioritiz…
Posted May 21, 2026
Genomic consequences of schistosome hybridization
US · IL NIH · grant
Hybridization between parasite species has the potential to transfer biomedically important genes across species boundaries with potential impact on host specificity, pathogenesis and drug resistance. It is widely assumed that there is freq…
Posted May 21, 2026
Mapping Drug Resistance Genes in Plasmodium falciparum
US · IL NIH · grant
ABSTRACT Drug resistance mutations disrupt key physiological processes resulting in severe fitness costs; compensatory mutations are expected to evolve to restore fitness. Such compensatory mutations are extensively studied in bacterial pat…
Posted May 21, 2026
Claustrum serotonin and spike-timing plasticity associated with cognitive deficits after cocaine
US · IL NIH · grant
Project Summary/Abstract Over 40 million individuals in the US have a substance use disorder (SUD), and therapies for treating SUD have remained largely inadequate for decades. One of the key challenges in SUD treatment is that many drugs o…
Posted May 21, 2026
Linking mitochondrial and synaptic weakness to schizophrenia
US National Institute of Mental Health · grant
Schizophrenia (SZ) is a heterogenous neurodevelopmental disorder in which the complex and interacting influences of genetics and environment drive neuropathological processes leading to symptom development. While the precise neuropathologic…
Posted May 21, 2026
Molecular Studies of Cellular Cytotoxicity
US · IL NIH · grant
The overarching goal of this research program is the investigation of the innate immune system with a primary focus on natural killer (NK) cells and their use in the treatment of cancer. Our group has been a globally recognized leader in th…
Posted May 21, 2026
NHGRI/DIR Flow Cytometry Core
US National Human Genome Research Institute · grant
The Flow Cytometry Core of the National Human Genome Research Institute has the goal of providing all NHGRI investigators access to high quality flow cytometry services that enhance the scope and breadth of their scientific research. Servic…
Posted May 21, 2026
Formative Research on How Faith Communities can Promote Lung Cancer Screening
US National Cancer Institute · grant
PROJECT SUMMARY/ABSTRACT Black or African American men experience the highest lung cancer incidence (60.6 per 100,000 people) and mortality rates (45.7 per 100,000 people) compared to any other racial/ethnic group of both men and women and …
Posted May 21, 2026
Establishing the neuropathologic and molecular features of a spontaneous canine model of peripheral neuropathy
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY/ABSTRACT Hereditary peripheral neuropathies (HPNs) are common disorders that involve degeneration of nerves in the peripheral nervous system. Common clinical signs include progressive muscle weakness, foot deformities, and s…
Posted May 21, 2026
BCCMA: Recovery of Aged Muscle After Disuse Atrophy (REMEDY): Targeting metabolism to accelerate recovery from disuse atrophy in aged mice
US · IL Department of Veterans Affairs · NAICS 541714 · grant
Older Veterans have a greater burden of multi-morbidity compared to the general population, resulting in frequent and re-occurring inpatient hospitalizations. The inability to recover from hospital acquired muscle weakness is linked to hosp…
Posted May 21, 2026
Molecular Networks in Aging and Caloric Restriction in Rhesus Monkeys
US · IL NIH · grant
SUMMARY Age is the greatest risk factor for a host of chronic diseases, including cancer, diabetes, cardiovascular disease and neurodegeneration. The mechanistic basis for this shared risk and its continued increase as a function of age is…
Posted May 21, 2026
Wisconsin Nathan Shock Center
US National Institute on Aging · grant
Abstract Overall The goal of the Wisconsin Nathan Shock Center (WiNSC) is to catalyze research at the interface of aging, metabolism, and translation, building an environment and infrastructure that will have a significant impact locally an…
Posted May 21, 2026
Novel Gene Therapy, Techniques, and Devices to Prevent Ventricular Tachycardia
US National Heart Lung and Blood Institute · grant
ABSTRACT In the United States, several hundred thousand people experience cardiac arrest each year, with the vast majority dying from this condition. Approximately two-thirds of cardiac arrest victims have previously suffered a myocardial …
Posted May 21, 2026
Regulation of Nuclear Akt by p53, MDM2 and Phosphoinositide Lipids Roles in Oncogenic Transformation and Tumor Progression
US National Cancer Institute · grant
PROJECT SUMMARY: 30 lines. The canonical phosphoinositide (PI) 3-kinase (PI3K)/Akt signaling pathway uses free membrane PI lipid to regulate cell growth and is frequently hyperactivated in cancer. Akt is also activated in the nucleus by poo…
Posted May 21, 2026
Phosphoinositide Signaling in Cytosol and Nucleus
US · IL NIH · grant
Project Summary The research proposed seeks to reveal mechanisms for spatial phosphoinositide (PI) signaling in the cytosol and nucleus. These pathways have broad implications for cancer, neurodegenerative disorders, and other diseases. PI …
Posted May 21, 2026
Determine the role of a monocarboxylate transporter in metabolism and intestinal motility
US · IL NIH · grant
PROJECT SUMMARY Monocarboxylate transporters (MCTs) mediate the transport of key metabolic intermediates, such as lactate, urate, and pyruvate, across cellular membranes. Despite their importance in metabolic homeostasis and their implicati…
Posted May 21, 2026
A platform for monitoring the efficacy and optimal dosing of long-acting ART
US · IL NIH · grant
Project Summary/Abstract The rapidly emerging modalities of long-acting antiretroviral therapy (ART) for treatment and prevention are based on a one-size-fits-all dosing strategy despite these being our first experiences in real-world sett…
Posted May 21, 2026
Advanced body composition imaging to improve outcomes in lung transplantation
US · IL NIH RePORTER · grant
PROJECT SUMMARY Median survival after lung transplantation (Tx) is only 6.7 years, compared to >11 years after other solid organ Tx. Obesity increases risk of death on the Tx waitlist, early severe lung injury (primary graft dysfunction, PG…
Posted May 21, 2026
Anticodon Engineered tRNA for the Treatment of Hereditary Eye Disease
US National Eye Institute · grant
Summary Nonsense mutations are point mutations that convert an amino acid encoding codon into a premature termination codon (PTC). The consequences of PTCs are nonsense-mediated mRNA decay, and for transcripts that persist, premature transl…
Posted May 21, 2026
Rodent Phenotyping Core
US National Eye Institute · grant
PROJECT SUMMARY The goal of the Rodent Phenotyping Core (RPC) is to increase the utility of mice and rats as model organisms for vision research at The University of Iowa. The availability of a centralized core for phenotyping will allow in…
Posted May 21, 2026