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Showing 25 / 20086 · page 30/804
Foundational Biology of Glaucoma GWAS Loci
US National Eye Institute · grant
Abstract Glaucoma is a neurodegenerative disease characterized by loss of retinal ganglion cells (RGCs) and their axons. Damage from glaucoma is permanent and may cause irreversible blindness. Glaucoma is a major public health problem in th…
Posted May 21, 2026
Evaluating Signs of Safety: A Deaf-Accessible Therapy Toolkit for AUD and Trauma
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT In partnership with Deaf-owned agency National Deaf Therapy (NDT), we propose the first-ever full-scale psychotherapy trial conducted in the Deaf community. The U.S. Deaf community – more than 500,000 Americans who …
Posted May 21, 2026
E. coli virulence gene expression during clinical UTIs in women
US National Institute of Allergy and Infectious Diseases · grant
To understand the pathogenesis of urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC), it is critical to both follow up on our determination of the transcriptional program enacted by UPEC during uncomplicated UTI…
Posted May 21, 2026
Tuning peptide specifities for T cell tolerance in Type 1 diabetes
US · IL NIH · grant
Project Summary/Abstract Type 1 Diabetes (T1D) is a classical T-cell mediated autoimmune disease and substantial data implicates insulin as a dominant autoantigen in T1D disease. In the NOD mouse model of T1D, notable studies have shown th…
Posted May 21, 2026
Thymic medullary epithelial cell turnover and control of immune tolerance
US · IL NIH · grant
A normal and robust immune system relies on the development of a diverse repertoire of T cells that are tolerant of self- tissues. The thymus is a critical site for the development and education of T cell to promote tolerance to self and th…
Posted May 21, 2026
Alterations of leukocyte integrin signaling leading to diabetes and autoimmunity
US · IL NIH · grant
Project Summary/Abstract The study of the genetic basis for type 1 diabetes (T1D) has benefited tremendously from examination of rare individuals with likely monogenic forms of the disease. Combined with GWAS, a number of polymorphisms in i…
Posted May 21, 2026
STAT3 variants as a rheostat of immune tolerance
US · IL NIH · grant
Project Summary/Abstract (Overall) Dysregulation of the immune system can have severe consequences on health and wellbeing. Although this is often a complex process, recent progress in human genetics has allowed for the identification of si…
Posted May 21, 2026
UCSF Type 1 Diabetes Research Center
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Overall Summary The University of California at San Francisco Diabetes Research Center (DRC) will function as a basic and clinical research enterprise at the forefront of type 1 diabetes (T1D) research. The DRC crosses the boundaries of Dep…
Posted May 21, 2026
The RSELVES Study: Remote Sensing of (older adult partners') Engagement in Life and Variability in Everyday Support
US · IL NIH · grant
PROJECT SUMMARY Alzheimer’s disease is a leading cause of functional disability among older adults worldwide. Despite the inevitability of functional impairment in Alzheimer’s disease, large heterogeneity in the rate and order that specific…
Posted May 21, 2026
Neuromuscular electrical stimulation for physical function maintenance during hematopoietic stem cell transplantation
US · IL NIH RePORTER · NAICS 541715 · grant
Hematopoietic cell transplantation (HCT) reduces physical function and muscle mass and increases fatigue. Neuromuscular electrical stimulation (NMES), when used as a stand-alone intervention, improves muscle strength and muscle mass in non-…
Posted May 21, 2026
Seattle Summer Research Program in Geriatrics and Disparities
US Veterans Affairs · grant
We are applying to renew the “Seattle Summer Research Program in Geriatrics and Disparities” at the VA Puget Sound Health Care System (VAPSHCS), Seattle, WA. The VAPSHCS ranks 4th in research funding among VAs and is home to one of the larg…
Posted May 21, 2026
Engineering T cells to overcome inhibitory receptor signals that limit the efficacy of adoptive cell therapy against ovarian cancer
US · IL National Institutes of Health · grant
PROJECT SUMMARY Over 20,000 women are diagnosed with ovarian cancer in the United States annually, and over half will die within five years. Outcomes have changed little in the last 20 years, highlighting the need for more effective therap…
Posted May 21, 2026
Chemical Exposure Facility Core
US · IL National Institutes of Health (NIH) · grant
PROJECT SUMMARY - Chemical Exposure Facility Core (CXC) The Chemical Exposure Facility Core (CXC), directed by Kim Anderson, supply passive sampling devices (PSDs) and analytical services to advance environmental health science. Members of …
Posted May 21, 2026
Chemical Mixtures Core
US National Institute of Environmental Health Sciences · grant
SUMMARY – CHEMICAL MIXTURES CORE The mission of the OSU SRC is to identify polycyclic aromatic hydrocarbons (PAHs) in the environment, to characterize their toxicity, to specify the environmental concentrations of those chemicals below whic…
Posted May 21, 2026
Project 3: Defining the biologic role and therapeutic implications of lncRNA in multiple myeloma
US · IL National Institutes of Health (NIH) · grant
Project Summary – Project 3 Dana-Farber Cancer Institute Our longstanding focus has been to understand the multiple myeloma (MM)-bone marrow stromal cell interaction. We have utilized integrated genomic and epigenomic analysis and our in …
Posted May 21, 2026
Defining correlates of protection from dengue illness in a long-term cohort study of multigenerational house-holds in Thailand
US · IL National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID) · grant
PROJECT SUMMARY Dengue viruses (DENV) cause a significant and unchecked burden of human death and disease, with vaccine development hindered by critical gaps in our understanding of how multi-serotypic protection against DENV is generated, …
Posted May 21, 2026
Adaptation of a PrEP Shared-Decision Making Tool for Family Planning Clinics
US National Institute of Mental Health · grant
Women account for ~20% of new HIV infections in the US, and are systematically under-accessed for HIV prevention. The intersection of patient-side barriers (lack of patient knowledge, perceived risk, and medical mistrust), and provider-side…
Posted May 21, 2026
Southwest EDRN Clinical Validation Center for Head and Neck Cancer
US National Cancer Institute · grant
Project Summary/Abstract The goal of the EDRN Southwest Clinical Validation Center for Head and Neck Cancer is to improve oropharyngeal cancer screening through the rigorous validation of salivary biomarkers. The scientific approach of our …
Posted May 21, 2026
Biomarker Developmental Laboratory
US National Cancer Institute · grant
Project Summary/Abstract Cancer screening can detect cancer early and reduce mortality. However, high false positive rates and low sensitivities of lung (LC) and ovarian cancer (OC) screening result in unnecessary surgeries and missed cance…
Posted May 21, 2026
Mechanism and Inhibition of HIV Reverse Transcriptase
US · IL National Institutes of Health (NIH) · grant
PROJECT SUMMARY / ABSTRACT The HIV-1 (Human Immunodeficiency Virus) is a member of the retroviral family which contains a single-stranded RNA genome and is the major etiological agent involved in the development of acquired immunodeficiency…
Posted May 21, 2026
Structure and Function of the VWF Helical Tubule Required for Hemostasis
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY/ABSTRACT Von Willebrand Disease (VWD), the most common bleeding disorder worldwide, is caused by mutations in von Willebrand Factor (VWF), a large multidomain protein. In the blood, VWF circulates as a long multimer of head-…
Posted May 21, 2026
Identification of optimum spectacle prescriptions for patients with Down syndrome
US National Eye Institute · grant
Project Summary/Abstract: It is known that individuals with Down syndrome (DS) have reduced visual acuity which may result from high levels of refractive error (sphere and cylinder) and elevated levels of higher-order aberrations that are p…
Posted May 21, 2026
Vision Science Training Program
US · OH NIH · grant
Project Summary / Abstract The graduate program in vision science at The Ohio State University has a long track record of training optometrists for careers as clinician scientists. The program has yielded many NIH funded investigators, clin…
Posted May 21, 2026
Short term training: Professional Students in Optometry Schools
US National Eye Institute · grant
Project Summary/Abstract The long-term objective of this program is to expand the number of optometrists trained in research within the profession of optometry to ensure a strong pipeline of individuals available to address the visual and o…
Posted May 21, 2026
EVALUATION AND TESTING SERVICES (ETS) FOR VACCINES AND OTHER BIOLOGICS FOR INFECTIOUS DISEASES
US · IL NIH · grant
The Evaluation and Testing Services (ETS) for Vaccines and Other Biologics for Infectious Diseases contract provides a variety of product development services from early feasibility studies through activities required for the submission of …
Posted May 21, 2026