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Showing 25 / 20086 · page 31/804
Defining the Role of Angiotensin II Type 2 Receptor in Bladder Physiology and Pathophysiology with Mouse Models
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY The complex communication mechanisms involved in bladder function are not fully understood. Due to this lack of physiological understanding, bladder diseases have remained challenging to treat, resulting in severe detriment …
Posted May 21, 2026
MOSAAIC Cognitive Assessment Reading Center Administrative Supplement
US · IL NIH · grant
Project Summary The Multiethnic Observational Study in American Asian and Pacific Islander Communities (MOSAAIC) is a landmark, NHLBI-funded longitudinal cohort study designed to address critical gaps in health research among Asian American…
Posted May 21, 2026
Multi-ethnic Observational Study in American Asian and Pacific Islander Communities (MOSAAIC): Expanding Recruitment to Adults Aged 65 and Older
US · IL National Institutes of Health (NIH) · grant
Project Summary Older adults of Asian American (AsA), Native Hawaiian, and Pacific Islander (NHPI) backgrounds represent one of the fastest growing demographics in the U.S. However, factors associated with healthy aging in these populations…
Posted May 21, 2026
Hawaiian, Asian American, and Pacific Islander (HAAPI) Coordinating Center
US National Heart Lung and Blood Institute · grant
SUMMARY/ABSTRACT People of Asian, Hawaiian, or Pacific Islander (AsA-NHPI) ancestry, while representing 7.7% of the US population, have been largely underrepresented from NIH-funded prospective epidemiologic studies. As a result, there are …
Posted May 21, 2026
Multi-ethnic Observational Study in American Asian and Pacific Islander Communities (MOSAAIC) Mental Health Administrative Supplement
US · IL NIH · $100-500k · grant
Project Summary The Multiethnic Observational Study in American Asian and Pacific Islander Communities (MOSAAIC) is a groundbreaking study focused on understanding cardiometabolic and mental health disparities in Asian Americans, Native Haw…
Posted May 21, 2026
THE PURPOSE OF THIS MODIFICATION IS TO DE-OBLIGATE NHLBI FUNDING FROM THE WOMEN'S HEALTH INITIATIVE (WHI) - CLINICAL COORDINATING CENTER (CCC).
US · IL NHLBI (National Heart, Lung, and Blood Institute) · grant
The overall goal of the Women’s Health Initiative (WHI) Renewal is to continue to serve as a resource for innovative epidemiological research and to expand knowledge about the determinants of cardiovascular disease among older women, succes…
Posted May 21, 2026
NCI Cancer Screening Research Network: Coordinating and Communication Center
US · IL National Cancer Institute (NCI), National Institutes of Health (NIH) · NAICS 541715 · grant
The promise of early detection to reduce the burden of cancer is an easily understood and highly desired intervention point in the cancer continuum. Recent developments of multicancer detection (MCD) technologies have fueled already strong …
Posted May 21, 2026
Cell-type specific excitability and molecular mechanisms of opioid seeking
US National Institute on Drug Abuse · grant
Project Summary / Abstract Substance use disorders (SUDs) afflict 1 in 10 individuals, and opioid overdose deaths have quintupled over the last 20 years. There is a critical need to develop interventions that can reverse or block opioid-ind…
Posted May 21, 2026
Epigenetic regulation of stress-potentiated ethanol drinking
US · IL NIH · grant
Epigenetic Regulation of Stress-Potentiated Ethanol Drinking PROJECT SUMMARY/ABSTRACT A common mechanism that regulates both stress-sensitivity and alcohol use is epigenetic regulation of gene transcription. Of particular importance in subs…
Posted May 21, 2026
Determinants of cardioprotection by circulating prohibitin-1 during sepsis
US · IL NIH · grant
ABSTRACT: Sepsis is a dangerous hyper-inflammatory condition that carries a mortality rate of 25% for uncomplicated cases and rises to 80% for patients who develop multiple organ dysfunction syndrome (MODS). No specific therapies for MODS e…
Posted May 21, 2026
Loyola-Ukrainian Catholic University International Bioethics Research Training Program
US John E. Fogarty International Center for Advanced Study in the Health Sciences · grant
Project Summary/Abstract The Loyola University Chicago-Ukrainian Catholic University (LUC-UCU) Doctoral and Post- Doctoral Bioethics Training Program will provide advanced doctoral-level education in research ethics in English to Ukrainian …
Posted May 21, 2026
Patterns in Women's Unmet Sexual and Reproductive Healthcare Needs Over the Life Course
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
ABSTRACT Unmet sexual and reproductive healthcare (SRH) needs are a significant problem in the United States and are associated with a broad spectrum of negative sexual and reproductive health outcomes. Consequently, it is essential to und…
Posted May 21, 2026
Optimizing the Implementation of Whole Health Coaching for Veterans with COPD
US · IL NIH · grant
Background: VHA has committed to building the Whole Health system of care in which Veterans are empowered and equipped to pursue their best possible vision of health and well-being through self-care, conventional clinical care, and compleme…
Posted May 21, 2026
Integrating Next Generation Simulator Training and Operating Room Performance Assessment into Orthopedic Residency Programs
US · IL NIH · grant
Project Summary/Abstract The long-term goal of this research is to improve patient safety by establishing simulator training and evaluation of surgical skills as essential components of orthopedic residency programs. Many orthopaedic surge…
Posted May 21, 2026
CK20-004, Duke-UNC Prevention Epicenter Program for Protecting Patients from Infections, Antibiotics Resistance and Other Adverse Events
US National Center for Emerging and Zoonotic Infectious Diseases · grant
Project Summary Healthcare-associated infections (HAIs) and antimicrobial resistance (AR) lead to adverse patient outcomes, including increased mortality, morbidity, and length of hospitalization. While progress in prevention is occurring, …
Posted May 21, 2026
An infection prevention dilemma: should we place patients with C. difficile colonization on contact precautions?
US · IL NIH · grant
Project Summary - Clostridioides difficile is a leading cause of infectious diarrhea and the most common cause of healthcare-associated infection (HAIs) in the US, resulting in >450,000 infections and 29,000 deaths annually. In fact, C. dif…
Posted May 21, 2026
Project 3: Film Formulation, PK/PD and Safety Studies of ZB-06
US · PA National Institutes of Health (NIH) · grant
PROJECT 3 - ABSTRACT The primary objectives of Project 3 are to optimize the vaginal film delivery system for the Human Contraception Antibody (HCA) and to perform assays to assess PK/PD and safety endpoints in vaginal samples from women in…
Posted May 21, 2026
Circuit basis of social behavior decision-making in a subcortical network
US National Institute of Neurological Disorders and Stroke · grant
Project Summary/Abstract This proposal responds to an FOA (RFA-NS-18-030) calling for 1) “novel approaches to understand neural circuitry associated with well-defined social behaviors;” 2) Distributed circuits that contribute to the coordi…
Posted May 21, 2026
Imaging neuromodulation in the brain
US · IL NIH · grant
Addiction involves brain systems mediating internal states of motivation, arousal and reward, as well as emotions. Such internal states influence goal-directed behaviors and decision-making. A common feature of such internal states is their…
Posted May 21, 2026
Advanced Mass Spectrometry Facility
US · IL NIH · grant
Historically the facility has supported on the order of 40 PIs each year involved with around 70 annual report level projects with around two-thirds of these projects coming from the NIDDK. Although useful metrics for some things, the PI-…
Posted May 21, 2026
SMART BIOELECTRONIC IMPLANTS FOR CONTROLLED DELIVERY OF THERAPEUTIC PROTEINS IN VIVO AND ITS APPLICATION IN LONG-TERM TREATMENT OF HEMOPHILIA A
US National Institute of Biomedical Imaging and Bioengineering · grant
Cell-based therapies, where naturally or artificially engineered cells secreting therapeutic proteins are grafted onto the body to act as biological drug factories, are an attractive approach for long-term treatment of chronic diseases such…
Posted May 21, 2026
Combinatorial and computational design of bnAb mRNA vaccines for HIV
US National Institute of Allergy and Infectious Diseases · grant
Many HIV vaccine candidates have failed clinical trials, as they were unable to elicit a potent and durable response to HIV viral challenge. Broadly neutralizing antibodies (bnAbs) have been identified in a number of HIV+ individuals with w…
Posted May 21, 2026
Nonviral delivery techniques for in vivo prime editing
US National Heart Lung and Blood Institute · grant
Gene editing is a promising strategy for treating or even permanently curing genetic diseases. In particular, a new technique called prime editing has the potential to make small targeted insertions, deletions, and substitutions with very h…
Posted May 21, 2026
Nucleic Acids Sequencing Core
US · IL NIH RePORTER · grant
GENETICS AND GENOMICS CORE FACILITY (WestCore) OF SD BRIN (RESEARCH) Summary/Abstract SD BRIN has made significant strides in building critical infrastructure to meet the needs of biomedical researchers in South Dakota. From 2004 to 201…
Posted May 21, 2026
Synthesis and Biochemical Evaluation of Ruthenium Compounds
US National Institute of General Medical Sciences · grant
Project Summary Transition metal compounds have been used as therapeutic agents. However, treatment with these compounds, for example cisplatin, can lead to drug resistance and poor efficacy. Ruthenium has been studied as an alternative to…
Posted May 21, 2026