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20,086 contracts

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Showing 25 / 20086 · page 34/804
Population and evolutionary dynamics of recombining genes and alleles in bacteria
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY/ABSTRACT Species are conventionally defined as groups of individuals that breed with each other and produce fertile offspring, but not with those of other species (according to Ernst Mayr's Biological Species Concept). Howe…
Posted May 21, 2026
MYC-regulated RNA Binding Protein Networks and Spliced Isoforms Driving Cancer
US National Cancer Institute · grant
SUMMARY Alternative RNA splicing is a key step in gene expression regulation and contributes to transcriptional diversity by selecting which transcript isoforms are produced in a specific cell at a specific time point. Aberrantly spliced is…
Posted May 21, 2026
Building a spatial transcriptomics infrastructure for isoform profiling in aging pre-neoplastic tissues
US · IL National Cancer Institute (NCI) · NAICS 541714 · grant
PROJECT SUMMARY/ABSTRACT Aging is the greatest risk factor for cancer, but it is not known which age-dependent cellular and molecular events drive cancer initiation. Spatial transcriptomic approaches are revolutionizing our understanding of…
Posted May 21, 2026
Vanderbilt Biomedical Informatics Training Program
US National Library of Medicine · grant
Vanderbilt University proposes a 5-year renewal of its Training Program in Biomedical Informatics and Data Science. Established in 2001, the Vanderbilt program offers MS and PhD degrees in biomedical informatics, nondegree postdoctoral trai…
Posted May 21, 2026
Reducing Off-Target Accumulation of Chemotherapeutic Nanomedicines
US · IL NIH · NAICS 541714 · grant
The work described in this proposal investigates a novel approach to reduce drug accumulation in healthy tissues and improve the efficacy of chemotherapy. More specifically, we take advantage of recent studies demonstrating an innate immune…
Posted May 21, 2026
Single-cell Analysis of Normal and Perturbed Dynamic and Spatial Biological Systems
US National Institute of Environmental Health Sciences · grant
The aim of this project is to utilize network models as a powerful framework to investigate the complexity, spatial organization and dynamics of biological processes during development from genetic, environmental and pharmacological perturb…
Posted May 21, 2026
Unraveling Drug Response Heterogeneity and Personalizing Treatment in Cancer
US National Institute of Environmental Health Sciences · grant
We developed PHENO-DEX, an experimental and machine-learning framework designed to characterize cancer cell response spectrums using dynamic molecular phenotypes. PHENO-DEX is specifically applied to dexamethasone (Dex) treatment, a widely …
Posted May 21, 2026
Benchmarking and Computational framework for Optimal Visualization and Interpretability of high-dimensional Spatiotemporal Data
US · IL NIH RePORTER · grant
Single-cell analysis have revolutionized biomedical research, enabling unprecedented insights into cellular heterogeneity, differentiation trajectories, and the mechanisms underlying complex diseases. Despite these advances, the interpretat…
Posted May 21, 2026
Cannabis, HIV and Mental Processing Systems (CHAMPS)
US · IL NIH · grant
ABSTRACT/PROJECT SUMMARY This proposal employs novel methods to identify key determinants and consequences of concurrent HIV infection and regular cannabis use. We will acquire extensive phenotype data from peripheral and brain markers of i…
Posted May 21, 2026
Alzheimer Disease Progression, Host Gut Microbiome, and Enteric Dysfunction
US · IL NIH · grant
Project 3: Project Summary/Abstract The gut microbiome (GM) is comprised of thousands of microbial taxa, with a vast repertoire of functional pathways that interact with the host environment. Dysbiosis of the GM is associated with numerous …
Posted May 21, 2026
Clinical Science Core
US National Institute of Allergy and Infectious Diseases · grant
Modified Clinical Science Core Project Summary/Abstract Section The Midwest D-CFAR Clinical Science Core (CSC) is committed to addressing the persistent clinical challenges posed by HIV and its related conditions. Despite significant progr…
Posted May 21, 2026
THE NIH NATIONAL NEUROHIV TISSUE CONSORTIUM (NNTC) - NEW CLINICAL SITE
US · IL NIH · grant
The purpose of this contract is to establish a new National NeuroHIV Tissue Consortium (NNTC) Clinical site as a critical resource for catalyzing high priority research in NeuroHIV (CNS complications in people with HIV), including studies t…
Posted May 21, 2026
Project 1: Biomarkers for Characterizing and Predicting AD in DS
US National Institute on Aging · grant
Project 1 Abstract An overarching theme of the Alzheimer's Disease Biomarkers-Down syndrome (ABC-DS) program is to characterize Alzheimer disease (AD) in Down syndrome (DS) and to determine if it has a pathological progression comparable to…
Posted May 21, 2026
THE ADMINISTRATION CORE (AC)
US NIH · grant
ABSTRACT FOR ADMINISTRATIVE CORE The Administrative Core (AC) will support the overall work of the Aging Adult Brain Connectome (AABC) to establish a focused program that identifies salient variables that affect the trajectory of brain str…
Posted May 21, 2026
Identifying neural circuits that support effortful listening
US National Institute on Deafness and Other Communication Disorders · grant
Project Summary/Abstract Candidate: My long-term career goal is to establish an independent research program focusing on the neural mechanisms of listening effort, and explore how adolescent hearing loss alters this mechanism. My previous t…
Posted May 21, 2026
The neural foundations of regulation in infancy and the role of individual and environmental factors over time
US · IL NIH · grant
Project Summary/Abstract The neural mechanisms of regulation support socioemotional competence 63,74 and may operate as resilience factors in the face of developmental risk for psychopathology 13,17. Investigating how these neural mechanis…
Posted May 21, 2026
Endoplasmic Reticulum (ER)-phagy in Influenza Infection
US National Institute of Allergy and Infectious Diseases · grant
Project Summary Influenza infection in susceptible patients results in a higher viral load, cytokine storm, tissue damage, lung function decline, and mortality. It is well known that interferons control influenza burden and inflammatory res…
Posted May 21, 2026
ERC Einstein Rockefeller CUNY Center for AIDS Research
US · NY · New York City NIH · grant
PROJECT SUMMARY ERC-CFAR: CLINICAL AND TRANSLATIONAL SCIENCE CORE (CTSC) To help meet the vision of Ending the HIV Epidemic (EHE), the Einstein-Rockefeller-CUNY Center for AIDS Research (ERC-CFAR) has formed strong collaborations both withi…
Posted May 21, 2026
Development of functional plasticity in a simplex retina.
US National Eye Institute · grant
PROJECT SUMMARY/ABSTRACT: Retinal sensitivity over the full range of environmental lighting conditions, from dark to bright, is mediated by rod and cone photoreceptors and is fundamental to vision. Importantly, when one type of photorecepto…
Posted May 21, 2026
Towards a biophysical model of human cortical neurophysiological signatures that incorporates cellular and cell type biophysics, transcriptomics, and morphology
US · IL National Institutes of Health (NIH) · grant
Project Summary The past decade has seen an unprecedented accumulation of data at the single-cell level giving rise to unique, multimodal sets of gene expression patterns, morphologies, and electrophysiology characteristics. This high- reso…
Posted May 21, 2026
A Computational Framework Enabling Virtual Imaging Trials of 3D Quantitative Optoacoustic Tomography Breast Imaging
US · IL NIH · grant
ABSTRACT Optoacoustic tomography (OAT), also known as photoacoustic computed tomography, is a non-invasive imaging modality actively being developed for breast cancer imaging and other biomedical applications. A unique feature of OAT is the…
Posted May 21, 2026
Computational imaging and intelligent specificity (Anastasio)
US · IL NIH RePORTER · grant
SUMMARY In this technology research and development (TRD) project, advanced computational and machine learning methods will be developed that address a variety of needs related to image formation and image analysis in high-resolution label-…
Posted May 21, 2026
Deep learning technologies for estimating the optimal task performance of medical imaging systems
US National Institute of Biomedical Imaging and Bioengineering · grant
ABSTRACT Modern medical imaging systems comprise complicated hardware and sophisticated computational methods. Given the sheer number of system parameters that impact image quality, the large variety in objects to be imaged, and ethical con…
Posted May 21, 2026
Developing Human Induced Pluripotent Stem Cell Precision Oncology Models
US National Cancer Institute · grant
Abstract This proposal was specifically designed to support a dedicated Research Specialist with extensive experience in human induced pluripotent stem cell (hiPSC) engineering to study the cellular and molecular mechanisms underlying the f…
Posted May 21, 2026
Mechanisms of Pol II Elongation in Diffuse Midline Glioma
US · IL NIH · NAICS 541714 · grant
Project Summary/Abstract Diffuse midline gliomas (DMGs) are aggressive brain tumors in both children and adults with no effective therapies. Over 80% of pediatric DMG and a majority of adult DMG harbor non-synonymous mutations in histone H3…
Posted May 21, 2026