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Showing 25 / 20086 · page 35/804
Making women's options for HIV prevention in Tanzania accessible and joining implementation science capacity building (MWOTAJI)
US · IL NIH · NAICS 541720 · grant
SUMMARY Adolescent girls and young women (AGYW; ages 15-24) in sub-Saharan Africa face a disproportionate burden of HIV infection. Though highly effective HIV prevention like pre-exposure prophylaxis (PrEP) is central to the global strategy…
Posted May 21, 2026
COMPUTATIONAL FRAMEWORKS FOR PHAGE DISCOVERY, ECOLOGY, AND DYNAMICS FROM METAGENOMES
US National Institute of General Medical Sciences · grant
Project Summary/Abstract Metagenomics sequencing is increasingly becoming important for human microbiome research. Human microbiomes comprise a rich ecosystem of beneficial and pathogenic microorganisms and bacteriophages that can influence…
Posted May 21, 2026
Pre and post-synaptic pathways underlying the stress response in the adrenal medulla
US · IL NIH · grant
ABSTRACT The “fight-or-flight” response refers to the state of heightened physiological and mental arousal triggered by a physical threat, emotionally charged event, or metabolic disturbance. Although the precise reaction to each stressor m…
Posted May 21, 2026
Determinants of inception of inflammation in inflammatory bowel diseases
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Project Summary Crohn’s disease (CD) and ulcerative colitis (UC) affect over 2 million individuals in the United States and are associated with considerable morbidity. Existing treatments achieve remission in fewer than 50% of patients. Fur…
Posted May 21, 2026
The Pediatric Advanced Cancer Experience (PACE): Measuring Quality of End-of-Life Care for Children with Cancer
US · IL NIH · grant
PROJECT SUMMARY Although cure rates for childhood cancer have increased over several decades, cancer remains the leading cause of non-accidental death in children. Yet, there are no existing quality measures to define optimal end-of- life c…
Posted May 21, 2026
Quantum Dynamic Investigations of Redox in Biology
US · IL NIH RePORTER · grant
Project Summary Establishing a fundamental understanding of redox processes in biology is a key challenge with the potential to transform research in areas ranging from the development of biomimetic materials for efficient energy harvestin…
Posted May 21, 2026
Molecular Determinants of Age-Related Cognitive Decline in the Basal Forebrain to Lateral Entorhinal Cortex Circuit
US National Institute on Aging · grant
PROJECT SUMMARY The entorhinal cortex (EC) is a critical mediator of cortico-hippocampal communication and thus essential for memory. Numerous studies identify the EC as the first brain region to display age-related changes such as accumula…
Posted May 21, 2026
Ambient Air Pollution, Weather, and Placental Abruption (APWA)
US National Institute of Environmental Health Sciences · grant
ABSTRACT Placental abruption results in hemorrhage, ischemia, and fetal hypoxia, placing a tremendous health burden on both the mother and the newborn. Efforts to understand the etiology of this devastating obstetrical complication have bee…
Posted May 21, 2026
The Effectiveness of Automated Multimodal Imaging in High Grade Squamous Intraepithelial Lesions (HSIL) Diagnosis for People Living with HIV: An International Trial
US · IL NIH · NAICS 541715 · grant
Abstract: Squamous cell cancer of the anus (SCCA) is increasing in the aging cohort of people living with HIV (PWH), who are at 40-80x higher risk for SCCA than the general population. The increase in invasive anal cancer, and its precursor…
Posted May 21, 2026
AI-Assisted Microendoscopy for the Early Detection of Esophageal Cancer
US · IL National Institutes of Health · grant
Abstract: Esophageal cancer is the 6th most common cause of cancer-related mortality worldwide. While esophageal squamous cell neoplasia (ESCN) carries a significant global burden, those in certain underserved geographic regions (South Amer…
Posted May 21, 2026
Interrogating unique DC adaptations to tissue to promote barrier immunity and tolerance
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Project summary: The immune system faces the external world and encounters pathogens, including viruses in barrier tissues (e.g. skin, lung, and gut). There the immune system must detect and respond to pathogens, while simultaneously preven…
Posted May 21, 2026
New mechanisms governing skin tissue residency memory T cells
US · IL NIH · grant
PROJECT SUMMARY Given the recent SARS CoV2 pandemic, and monkeypox outbreak, there is an urgent unmet need to understand immunity in our barrier tissues (e.g. skin, lung, and gut) where viruses are encountered. Tissue specific memory is nee…
Posted May 21, 2026
Cole Eye Institute Vision Science Training Program
US National Eye Institute · grant
ABSTRACT This is a first renewal application for continued funding for the Cole Eye Institute Vision Science Training Program (CEIVSTP) which is specifically designed to train pre-doctoral Ph.D. students, medical students and post-doctoral …
Posted May 21, 2026
Mechanobiology of Bruch’s membrane during aging: Implications for age-related retinal degenerations.
US National Eye Institute · grant
PROJECT SUMMARY Aging is a significant risk factor for age-related macular degeneration AMD, a leading cause of blindness among the elderly. Aging and AMD induce progressive changes in Bruch’s membrane but to varying extents. There is incre…
Posted May 21, 2026
CORE A - Administrative Core
US National Eye Institute · grant
Administrative Core Project Summary The Administrative Core will oversee the efficient use of resources and the equitable utilization of the services provided by the Cole Eye Institute Vision Research Core supported by this P30 Core grant f…
Posted May 21, 2026
Do Hair Cortisol and Hair Oxytocin represent the Stressful and Supportive Experiences of Preschool Children?
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Adverse childhood experiences (ACEs), parenting, and social determinants of health (SDH) contribute to early life adversity (ELA), which can disrupt development in the brain, cardiovascular, metabolic, and immune systems to increase the ris…
Posted May 21, 2026
Virus breathing and assembly-disassembly transitions in host-entry
US · IL NIH · grant
Project Summary Viruses are serious human pathogens and viral infectious diseases represent a continuing challenge for global human health. The long-term focus of my research program is to uncover host-induced changes in pathogenic human vi…
Posted May 21, 2026
Understanding Mechanisms that Regulate Liver Growth and Function
US · IL NIH · grant
Project Abstract Chronic liver diseases are on the rise and are associated with almost $100 billion in healthcare costs in the United States. Since the liver is a primary site for detoxification and metabolizes a variety of chemicals, presc…
Posted May 21, 2026
Determining the nigrostriatal circuit basis of false auditory perceptions.
US National Institute of Mental Health · grant
Project Summary/Abstract Auditory perception can become disrupted in disorders like autism and psychosis. Higher-order auditory pro- cessing occurs in the auditory thalamus and cortex. In turn, these areas project to the tail of the striatu…
Posted May 21, 2026
Harnessing machine learning to develop new antibiotics for Neisseria gonorrhoeae
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY/ABSTRACT This proposal presents a five-year research and career development plan focused on machine learning (ML)-guided antibiotic development for multidrug-resistant Neisseria gonorrhoeae. The candidate, Melis Anahtar, MD…
Posted May 21, 2026
Matching genotypes with personalized therapies: Development of a decision support infrastructure to augment the value of precision medicine
US · IL NIH · grant
Project Summary Despite the progress made in precision oncology, clinicians typically face a vast volume and variety of next- generation sequencing and molecular data that is frequently intuitively processed to support high-stakes decisions…
Posted May 21, 2026
Identifying Global Rejuvenation Mechanisms in Tissues that Reverses Age-Related Phenotypes in Planarians
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT The preservation of organ functions, such as eyesight and mobility, is a significant health concern in the elderly population. Organ frailty and disease progression are associated with the dysregulation of tissue ho…
Posted May 21, 2026
Brainstem circuitry for sleep-wake control
US · IL NIH · NAICS 541715 · grant
PROJECT SUMMARY/ABSTRACT It is now clear that poor sleep quality has dramatic health consequences, yet sleep medicine is still in great need for safe and efficient sleep aids. Recent major advances in understanding how the brain regulates …
Posted May 21, 2026
Impaired Sleep as a Target for Intervention Following Acute Organophosphate Intoxication
US · IL NIH · grant
Organophosphate cholinesterase inhibitors (OPs) were developed as agricultural insecticides and adapted to function as chemical weapons. OPs inhibit the acetylcholinesterase enzyme and acute intoxication can lead to a cholinergic crisis, st…
Posted May 21, 2026
INVESTIGATING THE ROLE OF HIPPOCAMPUS - ORBITOFRONTAL CIRCUITS FOR COGNITIVE FLEXIBILITY
US · IL NIH · NAICS 541715 · grant
PROJECT SUMMARY Cognitive flexibility allows an individual to adapt established thinking patterns and behavioral responses to novel situations that may require new approaches than those that were previously learned in order to be solved cor…
Posted May 21, 2026