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Showing 25 / 20086 · page 38/804
The Role of Prenatal Cannabis Exposure in Reward-related Neural Circuitry and Psychotic-like Experiences in Youth
US National Institute on Drug Abuse · grant
PROJECT SUMMARY Cannabis use is becoming increasingly common in the US, and past-month use among pregnant women increased by almost 60% from 2003 to 2019. Despite increasingly permissive legislation, our knowledge of the behavioral and neu…
Posted May 21, 2026
Component for Institution # 269291
US · IL NIH · grant
SUMMARY The current HIV-1 pandemic is one where people living with HIV (PWH) have had well-suppressed infection with therapy for prolonged periods of time. This has guided research towards focusing on (i) comorbidities (aging, cardiovascula…
Posted May 21, 2026
Investigating the role of cGAS signaling and microglial senscence in tauopathy
US National Institute on Aging · grant
PROJECT SUMMARY Innate immune antiviral pathways are upregulated in Alzheimer’s disease (AD) and are thought to drive AD pathogenesis. The specific mediators of maladaptive antiviral responses in AD are still not understood. Innate immune s…
Posted May 21, 2026
Randomized Control Trial of oxygen therapy in Children and Adolescents with Down Syndrome and Obstructive Sleep Apnea
US National Heart Lung and Blood Institute · grant
ABSTRACT: A large percentage of children with Down Syndrome (DS) have obstructive sleep apnea (OSA) that is suboptimally treated by first-line surgical interventions. The persistence of OSA-related nightly intermittent hypoxemia and fragmen…
Posted May 21, 2026
Evaluation of a specific LXR/PPAR agonist for treatment of Alzheimer's disease
US National Institute of Neurological Disorders and Stroke · grant
Project Summary Alzheimer's disease (AD) is the sixth leading cause of death in United States, yet this indication lacks truly effective therapeutics to mitigate this disease. To develop novel and effective therapies, a novel (partial) L…
Posted May 21, 2026
Biospecimen Repository Core
US · IL National Institute of Neurological Disorders and Stroke (NINDS) · grant
The NINDS Biospecimen Core Facility was established in February 2023 in a newly renovated laboratory space, Room 2N104, located in Building 10. As of September 2024, the repository is actively storing, maintaining, and distributing samples…
Posted May 21, 2026
Project 1: Biomimetic Interactions Between Bacterial Pathogens and the Gastrointestinal Epithelium
US · IL NIH · grant
PROJECT SUMMARY (Project 1) Helicobacter pylori and Salmonella enterica serovar Typhi (Typhi) are both strictly human-adapted pathogens that colonize the stomach and intestine and are major public health threats worldwide that disproportion…
Posted May 21, 2026
Core B: Translational, Cellular and Molecular Analysis
US National Cancer Institute · grant
ABSTRACT – CELLULAR IMAGING AND GENOMICS CORE B Core B, the Cellular Genomics and Imaging Core (CGI), will provide centralized experimental processing services and primary data analysis for the Program Project Grant (PPG). The interactions …
Posted May 21, 2026
A self-administered PrEP Decisional Aid for dissemination with HIV self-test kits (DASH)
US National Institute of Mental Health · grant
Project Summary Our mixed-methods implementation hybrid (type I) pilot RCT will develop a self-administered PrEP Decisional Aid for dissemination with Self-administered HIV test kits (DASH), and pilot it with 120 users of the Together Take …
Posted May 21, 2026
Elucidating the Role of C16orf72 in the Cellular Stress Response Network
US · IL NIH · grant
PROJECT SUMMARY A hallmark of cancer is the ability of malignant cells to maintain viability in the face of stressors such as aneuploidy, nutrient scarcity, and xenobiotic compounds. This multi-stress-resilience phenotype enables tumor form…
Posted May 21, 2026
Capacity building for timely diagnosis of Multiple Sclerosis and prevention of disability
US John E. Fogarty International Center for Advanced Study in the Health Sciences · grant
Abstract This application proposes to address priority areas for improvement in the care of multiple sclerosis (MS) in Colombia (a low-middle income country), which is a country with a population that is ancestrally and genetically diverse…
Posted May 21, 2026
Prenatal Exposure to Organophosphate Ester Flame Retardants and Plasticizers (OPEs), Gene-Environment Interaction, and Child Neurodevelopment
US · IL NIH · grant
ABSTRACT The prevalence of autism and attention-deficit/hyperactivity disorder (ADHD) is increasing, yet their etiology is poorly understood. A complex combination of environmental and genetic factors appears to contribute to both condition…
Posted May 21, 2026
Interactions of Environmental Chemical Mixtures, Genetics, and Immune Pathways in Autism Spectrum Disorder
US National Institute of Environmental Health Sciences · grant
ABSTRACT The rising prevalence of Autism Spectrum Disorder (ASD) among children is a public health concern. An expanding landscape of genetic and environmental risk factors has been implicated in ASD’s development, indicating complex, multi…
Posted May 21, 2026
A Brief Values Intervention to Support Veterans in Early Buprenorphine Treatment
US National Institutes of Health (NIH) · grant
The proposed Career Development Award (CDA-2) would support Dr. Victoria Ameral, Clinical Research Psychologist with the VISN 1 New England Mental Illness Research, Education, and Clinical Center (MIRECC) and recent graduate of the VA Inter…
Posted May 21, 2026
THE ROLE OF THE NON-CANONICAL INFLAMMASOME IN INNATE IMMUNITY
US · IL NIH RePORTER · grant
ABSTRACT Legionella pneumophila is an infectious bacterium that causes Legionnaire’s disease and remains a major cause of morbidity and mortality in the immunocompromised individuals such as the elderly and cancer patients. Macrophages are …
Posted May 21, 2026
Targeting specific MicroRNA to alleviate Alzheimer’s Disease pathobiology
US · IL NIH · NAICS 541714 · grant
Targeting microglia to alleviate Alzheimer’s Disease pathobiology Summary Alzheimer’s disease (AD) is the most common cause of age-related dementia leading to irreversible neurodegeneration and cognitive decline with no cure or effective pr…
Posted May 21, 2026
Role of the Non-canonical Inflammasome in SARS-CoV-2-mediated Pathology and Coagulopathy
US · IL NIH · grant
OVERALL - ABSTRACT COVID-19 is a world-wide health problem caused by SARS-CoV-2 viral infection in the lung with long-term symptoms in at least one third of patients. Many COVID-19 patients suffer from silent or identified thrombi in major …
Posted May 21, 2026
Quantifying cerebellar multi-omic and synaptic features of autism spectrum disorders
US National Institute of Mental Health · grant
Project Summary Strong, longstanding evidence points to important roles for the cerebellum in autism spectrum disorders (ASDs), yet cerebellar mechanisms remain understudied in ASDs compared to neocortical circuits. Anatomical and functiona…
Posted May 21, 2026
Multi-scale consequences of variants in the schizophrenia risk gene SETD1A in a population isolate.
US · IL NIH · grant
Project Summary. Rare variants with large effects provide excellent opportunities to characterize causal mechanisms for complex disorders. Recently, large-scale exome sequencing of schizophrenia found that rare protein-truncating and missen…
Posted May 21, 2026
Irx1 regulation of oral tissue repair and maintenance.
US National Institute of Dental and Craniofacial Research · grant
Project Summary Oral disease causes a significant burden on overall health and 3.9 billion people are affected worldwide. Oral diseases such as periodontitis, cancer, tooth loss, craniofacial birth defects and pain all affect growth and ma…
Posted May 21, 2026
Integrative Center for Environmental Microbiomes and Human Health
US National Institute of General Medical Sciences · grant
Project Summary – OVERALL We seek to strengthen and enhance the Integrative Center for Environmental Microbiomes and Human Health (ICEMHH). Our center was established in response to the 2016 announcement of the National Microbiome Initiativ…
Posted May 21, 2026
Role of CRTC1-MAML2 in Salivary Mucoepidermoid Carcinoma Pathobiology
US National Institute of Dental and Craniofacial Research · grant
Summary Mucoepidermoid carcinomas (MEC) are the most common type of malignant salivary gland tumor (SGT) with advanced MEC often being fatal due to resistance to conventional therapies. Despite their prevalence in salivary malignancies and …
Posted May 21, 2026
Leveraging Data Science Applications to Improve Children's Environmental Health in Sub-Saharan Africa (DICE)
US National Institute of Environmental Health Sciences · grant
Project Abstract Poor environmental conditions such as air pollution, and unsafe water and sanitation have been ranked among the top risk factors for disability-adjusted years (DALYs) in children. The highest number of deaths per capita att…
Posted May 21, 2026
Telemetric Regenerative Bandage for Accelerating Wound Healing
US · IL NIH · grant
Summary Diabetic foot ulcers (DFUs) are a major complication of diabetes. These sores, if left untreated, can become infected and become a serious threat to the patient’s well being. Although the field of wound care management is well estab…
Posted May 21, 2026
Low-Profile 3D-Printed Radiopaque Bioresorbable Vascular Scaffolds
US · IL NIH · grant
PROJECT SUMMARY Atherosclerotic coronary artery disease (CAD) and peripheral artery disease (PAD) are responsible for significant morbidity, mortality, and high healthcare costs in the USA. This problem will continue to grow due to the dia…
Posted May 21, 2026