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Showing 25 / 20086 · page 39/804
Regenerative Engineering Training Program (RE-Training)
US National Institute of Biomedical Imaging and Bioengineering · grant
Summary for the Regenerative Engineering Training Program A major health challenge that our society faces is premature death and morbidity associated with the shortage of healthy donor tissues or organs for transplantation and the limited r…
Posted May 21, 2026
Developing a SMART scaffold for bladder augmentation
US · IL NIH · grant
SUMMARY Each year in the United States there are 14,000 bladder augmentation enterocystoplasty surgeries to address trauma, urological cancers, severe cases of spina bifida, and interstitial cystitis. Although enterocystoplasty is the stand…
Posted May 21, 2026
Biochemical Analysis of Multidrug Resistance-linked Transport Proteins
US National Cancer Institute · grant
Clinical resistance to multiple chemically and functionally dissimilar drugs is multifaceted. P-glycoprotein (P-gp, ABCB1) and ABCG2 appear to contribute to this problem due to their broad and overlapping substrate specificities. Both trans…
Posted May 21, 2026
Molecular Mechanisms Regulating Calcium Flux In Salivary Glands
US National Institute of Dental and Craniofacial Research · grant
Research Advances Our key findings in this fiscal year are as follows: 1.STIM proteins, STIM1 and STIM2, play important roles in the activation of store-operated calcium entry (SOCE) through their interaction with the plasma membrane Ca2+…
Posted May 21, 2026
Novel Markers for Disease Outcome in Breast Cancer
US · IL NIH · grant
Project 1: The mechanisms through which chronic stressors may be associated with tumor biologic characteristics, immune response, and health disparities remain insufficiently understood. Hence, we investigated the proteomic, transcriptomic,…
Posted May 21, 2026
Maryland Prostate Cancer Case-Control Study
US · MD · Baltimore NIH · grant
Our study was implemented in two phases. The first phase, which started in April of 2005, constituted a pilot study to evaluate recruitment procedures. This phase was successful, and the full study was initiated with minor changes to the pr…
Posted May 21, 2026
The Molecular Profile of Prostate Tumors in African-American Men
US · IL NIH · grant
Currently, genomic risk, including genetic ancestry-inferred risk, is considered a nonmodifiable risk factor. Previous studies have shown that West African genetic ancestry is linked to increased prostate cancer risk among Black men, whose …
Posted May 21, 2026
Harnessing Artificial Intelligence and Deep Learning to Determine a Coronary Artery Calcium Estimate in Patients with No History of AtheroSclerotic CardioVascular Disease (HIDDEN-ASCVD) Study
US · IL NIH · grant
PROJECT SUMMARY/ ABSTRACT Data science advances have led to the emergence of opportunistic imaging screening – applying algorithms to screen for conditions from imaging performed for other purposes. Opportunistic screening for coronary arte…
Posted May 21, 2026
Disparities in REsults of Immune Checkpoint Inhibitor Treatment (DiRECT): A Prospective Cohort Study of Cancer Survivors Treated with anti-PD-1/anti-PD-L1 in a Community Oncology Setting
US National Cancer Institute · grant
ABSTRACT Immune checkpoint inhibitors (ICIs) are a powerful and innovative mode of cancer therapy, believed to be partially responsible for the largest single-year drop in cancer mortality from 2016 to 2017. Their use has increased dramatic…
Posted May 21, 2026
2/2 PROmote weight loss in obese PAD patients to preVEnt mobility loss: The PROVE Trial--DCC
US · IL NIH · grant
The PROVE Trial DCC Project Summary This U24 application from the Wake Forest School of Medicine (WFSM) describes plans by experienced inves- tigators and staff to serve as the Data Coordinating Center (DCC) for the PROmote weight loss in o…
Posted May 21, 2026
2/2 Improving Mobility After Revascularization in Peripheral Artery Disease: The IMPACT PAD Trial
US · IL NIH · grant
The IMPACT PAD Trial DCC Project Summary This U24 application from the Wake Forest University School of Medicine (WFUSM) describes plans by expe- rienced investigators and staff to serve as the data coordinating center (DCC) for the IMProvi…
Posted May 21, 2026
Sex Dimorphism in Age-Related Knee Osteoarthritis
US · IL NIH RePORTER · grant
As indicated by the 2019 Global Burden of Disease Study, although women, on average, have a longer lifespan than men, women typically experience worsened health outcomes as they age. Notably, postmenopausal women have a higher incidence of …
Posted May 21, 2026
The opposing effects of matrix aging and muscle activity on extracellular vesicle promotion of muscle regeneration
US · IL NIH · grant
ABSTRACT Young skeletal muscle displays remarkable resilience following an acute injury event, evidenced by a robust regenerative response and functional recovery. In contrast, even a relatively minor injury to aged muscle can result in si…
Posted May 21, 2026
Innovations in Myogenesis: From Molecular Mechanisms to Therapeutic Interventions
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. The goal of the Frontiers in Myogenesis meeting – Innovations in Myogenesis: From Molecular Mechanisms to T…
Posted May 21, 2026
Genetic information flow in the Hallmarks of Aging: from system-level analytics to mechanistic interventions
US · IL NIH · grant
ABSTRACT Although aging is understood as a system-wide deterioration of cell and tissue function, it is nevertheless associated with specific hallmarks, first introduced by López-Otín et al. in 2013. Because these hallmarks have traditional…
Posted May 21, 2026
Deciphering the Role of Gut Microbiome in Inflammatory Bowel Disease Using a Canine Patient-Specific Gut-on-a-Chip
US · IL NIH ORIP · grant
PROJECT SUMMARY This NIH ORIP K01 award application describes a 5-year training plan designed to allow me to gain additional skill and knowledge so that I can transition to an independent R01-funded tenure track research scientist. In carry…
Posted May 21, 2026
Reversing Skeletal Aging by Restoring Functional Skeletal Stem Cell Diversity
US · IL NIH · grant
Advancing age is tightly linked to the increasing global incidence of skeletal diseases. Osteoporosis poses a major public health threat for over 54 million Americans as it is interrelated with high fracture rates. Osteoporosis related hip …
Posted May 21, 2026
Skeletal Stem Cell-based Cartilage Regeneration in Aged and Osteoarthritic Niches
US National Institute on Aging · grant
Project Summary Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progressive destruction of hyaline cartilage lining articular joints. A critical challenge for OA management is the development of an effective treatme…
Posted May 21, 2026
Deciphering HIV-1 Resistance Pathways against Capsid Inhibitors in vitro and in Humanized Mice
US · IL NIH · grant
PROJECT SUMMARY The HIV-1 capsid, a cone-shaped protein shell, is a promising target for antiviral interventions, with lenacapavir (LEN), a potent capsid inhibitor, demonstrating efficacy in treatment and prevention. However, resistance to …
Posted May 21, 2026
Genetic control of developmental timing
US · IL NIH · NAICS 541715 · grant
1 Project Summary/Abstract Development of even the simplest of multicellular animals is astonishingly complex, involving the spatial and temporal orchestration of cellular proliferation, differentiation, and morphogenesis throughout the de…
Posted May 21, 2026
Antibodies against Oxidized Phospholipids and Osteoporosis
US · IL NIH · NAICS 541714 · grant
Phosphatidylcholine is the most common phospholipid in cell membranes, microvesicles, and lipoproteins; it contains the phosphocholine head group (PC) and polyunsaturated fatty acids (PUFA) that are susceptible to lipid peroxidation by reac…
Posted May 21, 2026
Investigating the EBV methylome in PLWH: Discovery and Development of Novel EBV Diagnostics in Plasma and Saliva
US National Cancer Institute · grant
ABSTRACT EBV(+) lymphomas are an important cause of death in people living with HIV (PLWH). Different patterns of viral and cellular gene expression have been found to characterize different subtypes of EBV(+) lymphomas. CpG methylation of …
Posted May 21, 2026
Enrichment for Tumor-derived Cell-free EBV DNA: Towards a Diagnostic Assay for Endemic Burkitt Lymphoma
US National Cancer Institute · grant
PROJECT SUMMARY Endemic Burkitt lymphoma (eBL) outcomes in children with advanced stage disease are markedly inferior to those in children with early-stage disease. eBL is one of the most rapidly growing tumors. As a result, diagnostic del…
Posted May 21, 2026
Defining the role of SINE retrotransposons and inflammasome activation in Alzheimer's disease
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY Pathological hallmarks of Alzheimer's disease (AD) include deposition of Amyloid-β (Aβ) plaques and accumulation of hyperphosphorylated Tau aggregates in neurofibrillary tangles. These aggregates have been demonstrated to ac…
Posted May 21, 2026
Cytosolic SINE retrotransposable element cDNA and mitochondrial DNA in aging retina
US · IL National Institutes of Health (NIH) · NAICS 541715 · grant
PROJECT SUMMARY The retinal pigmented epithelium (RPE) is an amitotic, long-lived cell type that supports healthy visual function for numerous decades. The aging retina displays pathologic features that are exaggerated in a complex disease …
Posted May 21, 2026