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20,086 contracts

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Showing 25 / 20086 · page 40/804
UAB Outcomes of Babies with Opioid Exposure (OBOE study)
US · AL NIH · grant
Project Summary Limited data are available on the effects of prenatal opioid exposure on the brain and neurodevelopment. The Outcomes of Babies with Opioid Exposure (OBOE) study, an ongoing NICHD-funded longitudinal study enrolling infants…
Posted May 21, 2026
UAB Clinical Site HEAL Neonatal Opioid Withdrawal Pharmacological Treatments
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Project Summary Many infants exposed to opioids antenatally develop Neonatal Opioid Withdrawal Syndrome (NOWS). The overarching goal of the HEAL Initiative: Neonatal Opioid Withdrawal Syndrome Pharmacological Treatments Comparative Effecti…
Posted May 21, 2026
Vital Signs In Opioid-Exposed Neonates
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Project Summary Rates of opioid use during pregnancy are at epidemic proportions. Infants exposed to opioids before birth frequently develop neonatal opioid withdrawal syndrome (NOWS) and are at a much higher risk of sudden infant death sy…
Posted May 21, 2026
Let-7b in BPD
US · IL National Heart Lung and Blood Institute · grant
Project Summary Bronchopulmonary dysplasia (BPD) is common in extremely low birth weight (ELBW) infants. Recently, we discovered that the strongest biomarker signal was of microRNA let-7b-5p, with a 46-fold increase (p<0.001) at birth in t…
Posted May 21, 2026
Identifying the Role of the IL-6/STAT3 Signaling Pathway in Higher-risk Myelodysplastic Syndrome
US Veterans Affairs · grant
Myelodysplastic syndromes (MDS) are myeloid malignancies most commonly diagnosed at an advanced age. They are considered a spectrum of malignancies that can range from low to high grade and they are classified based on an international prog…
Posted May 21, 2026
Differential routing of valence information through the basolateral amygdala
US · IL National Institutes of Health (NIH) · grant
Project Summary Decision-making is critical for survival but is a complex process to understand at the level of brain function. Animals and humans alike can use two strategies to solve problems of decision-making: goal-directed or habitual…
Posted May 21, 2026
Cancer Biology Research Test-Bed Unit 1: Effects of cell-intrinsic and cell-extrinsic signaling and mechanics on metastasis patterns of pediatric sarcomas
US · IL NIH · grant
Ewing sarcoma, a malignant tumor of bone and soft tissue affecting children, adolescents, and young adults. For the one-third of Ewing sarcoma patients who develop metastasis, the long-term survival rate remains less than 30%. Decades of cl…
Posted May 21, 2026
Identifying non-human primate models for specific human microbiome traits
US NIH Office of the Director · grant
Abstract: The gut microbiota is increasingly recognized as an important contributor to a range of human physiological processes and is attracting increasing attention as a dynamic area for the development of therapeutics. To realize the pot…
Posted May 21, 2026
Defining the role of Sf1 in urethral closure
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Hypospadias is one of the most common birth defects in the world affecting nearly 1% of newborn boys. Hypospadias is the result of disrupted urethral closure where the urethra exits ventrally along the shaft of the penis. The etiology of 70…
Posted May 21, 2026
Investigating the role of FOXL2 during urethra closure
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Project Summary Hypospadias is one of the most common birth defects in the world, affecting nearly 1% of newborn boys. Hypospadias is abnormal urethra closure, where the urethra exits ventrally along the shaft of the penis, and not the tip.…
Posted May 21, 2026
Multiscale Computational Microscopy of HIV-1
US National Institute of Allergy and Infectious Diseases · grant
ABSTRACT The human immunodeficiency virus 1 (HIV-1) is the RNA retrovirus that causes acquired immunodeficiency syndrome (AIDS), a disease that has killed over 40 million people worldwide and infected more than twice that. Continued high in…
Posted May 21, 2026
Developing a Single-Session Intervention to Support Adolescent Siblings of Children with Cancer
US National Cancer Institute · grant
PROJECT SUMMARY/ABSTRACT Adolescent siblings of children with cancer are at-risk for psychological distress and report unmet needs in response to their sibling’s cancer diagnosis and treatment. However, most siblings do not have access to s…
Posted May 21, 2026
Identifying ancestry-specific and distal components of disease-associated gene regulation and cellular function
US · IL National Institutes of Health (NIH) · NAICS 541714 · grant
Summary/Abstract Genome-wide association studies (GWAS) have associated hundreds of thousands of genetic variants with human disease and complex traits. 90% of associated variants reside in noncoding sequences that can enhance or suppress g…
Posted May 21, 2026
Mechanotransduction mechanisms of ovarian aging
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Aging affects all tissues and is associated with functional deterioration. Each tissue has specific aging kinetics, and the female reproductive system is the first to age. Female reproductive aging is associated with a decrease in oocyte …
Posted May 21, 2026
Targeting autophagy to enhance immune checkpoint inhibition
US National Cancer Institute · grant
Project Summary – Project 2 A new approach that can overcome resistance to immune checkpoint inhibition (ICI) is a major unmet need for Stage IV melanoma patients. The overall goal of this project is to determine if combined ICI with autoph…
Posted May 21, 2026
Resistance mechanisms to autophagy-modulating therapies
US · IL NIH · grant
Project Summary Although targeted therapy and immune checkpoint inhibitors have made a major impact on survival for some patients with advanced cancer, the majority of patients do not respond to standard of care treatments. Abundant eviden…
Posted May 21, 2026
Identification and Characterization of Entry Factors Critical for Rift Valley Fever Virus Infection and Pathogenesis
US National Institute of Allergy and Infectious Diseases · grant
Project Summary/Abstract Rift Valley fever virus (RVFV) is a phlebovirus that belongs to the Phenuiviridae (formerly Bunyaviridae) family of negative-sense RNA viruses. As an emerging mosquito-borne virus, the significance of RVFV is highli…
Posted May 21, 2026
Biochemical and structural mechanisms at the filoviral-host interface
US National Institute of Allergy and Infectious Diseases · grant
RP01 Project Summary/Abstract for Biochemical and structural mechanisms at the filoviral-host interface The recent filoviral outbreaks, including the 2013-2016 Ebola virus (EBOV) outbreak in West Africa that introduced the virus to other co…
Posted May 21, 2026
Characterizing the role of LDL related receptor 1 (Lrp1) as host entry factor for multiple bunyaviruses
US National Institutes of Health (NIH) · grant
Project Summary/Abstract Bunyaviruses (Order: Bunyavirales) are a growing and diverse family of animal and human pathogens with pandemic potential. With over 300 members and an expanding distribution of mosquito and tick vectors due to clim…
Posted May 21, 2026
Promoting a Broad, Sustainable NIDDK-Supported Workforce through Mentoring Early Career Investigators: Focus on Health Outcomes
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Modified Project Summary/Abstract The broad, long-term objectives of this proposal are two-fold: 1) to provide high-quality mentoring to contribute to the career development of trainees from varying backgrounds and 2) to advance the quality…
Posted May 21, 2026
Modeling Core
US National Institute of Allergy and Infectious Diseases · grant
Project Summary/Abstract – Modeling Core The Modeling Core, as part of SCRIPT, aimed to apply machine learning approaches to clinical and -omics data generated by the SCRIPT projects and cores to develop a models of severe pneumonia and ide…
Posted May 21, 2026
Project 003 - Lorena Amaral
US National Institute of General Medical Sciences · grant
Preeclampsia (PE) affects 5-7% of all pregnancies in the U.S and 30% of hypertensive disorders in pregnancy are caused by chronic hypertension (HTN) prior to pregnancy which increases the risk of superimposed PE (SIPE). Despite being a le…
Posted May 21, 2026
Project IV
US · IL NIH · grant
Project Summary Preeclampsia (PE) affects 5-7% of all pregnancies in the U.S. Despite being a leading cause of maternal death and perinatal morbidity, the most widely accepted treatment is early delivery of the baby. Healthy pregnancy is as…
Posted May 21, 2026
Brain and Behavioral Development in Autism Spectrum Disorder
US National Institute of Mental Health · grant
Adolescence is a complex time of heightened self-consciousness, risk taking and peer orientation which may be especially challenging for teens diagnosed with autism spectrum disorder (ASD). Longitudinal magnetic resonance imaging (MRI) stud…
Posted May 21, 2026
Genetic Strategies for Neurodevelopmental Research
US · IL NIH · NAICS 541714 · grant
Autism Spectrum Disorder (ASD) affects 1-2% of children in the United States. The etiology(ies) and neurobiological underpinnings of autism remains unclear and hence targets for effective medical treatments are rare. While myriad genetic mo…
Posted May 21, 2026