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Showing 25 / 20086 · page 42/804
Hierarchies of spatiotemporal anticipation in the human brain
US · IL NIH · grant
PROJECT SUMMARY Everyday experience requires humans to make plans in a hierarchical fashion, so they can anticipate visual events that might occur seconds, minutes, hours, or longer in the future. For example, when walking through a city, i…
Posted May 21, 2026
Exploring prevention-related health beliefs of emerging adults with a family history of type 2 diabetes
US · IL NIH RePORTER · grant
Type 2 diabetes (T2D) has reached epidemic levels in the United States and, alarmingly, cases of early-onset T2D are steadily rising, with nearly 305,000 new cases diagnosed among 18 to 44 year-olds in the United States each year.1,2 Early-…
Posted May 21, 2026
Rapid sugar sensing from gut to brain
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT The average American adult consumes over 40 pounds of sugar per year. While sugar intake is necessary for energy metabolism and survival, this overconsumption has led to rampant obesity and diabetes. Therefore, it i…
Posted May 21, 2026
Steroid hormone dependent gene expression and neuroplasticity in the brain
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY Steroid hormones in humans and other animals coordinate physiological and behavioral processes underlying optimal responses to the social environment. The brain is a major site of steroid hormone action; however, our knowled…
Posted May 21, 2026
Non-Invasive Venous waveform Analysis (NIVA) for Monitoring Volume Status in Heart Failure Patients
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY The primary focus of this research proposal is the refinement and advanced optimization of the Non-Invasive Venous waveform Analysis for Heart Failure (NIVAHF) device, building upon the foundational achievements made under R…
Posted May 21, 2026
Centrifugal regulation of olfactory function by melanin-concentrating hormone
US · IL NIH · grant
Project Summary The sense of smell is essential for maintaining full human health and quality of life. It plays an important role in the detection of environmental dangers as well guiding decisions such as what foods to eat. However, olfact…
Posted May 21, 2026
Modulating Fibrinolysis Dynamics by Leveraging Multivalent Avidity to Control Enzyme Activity
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY Blood clots kill more humans than any other single pathogenic cause. A new or recurrent diagnosis of venous thromboembolism (VTE), which encompasses both pulmonary embolism (PE) and deep vein thrombosis (DVT), affects >900,0…
Posted May 21, 2026
Development of in Vivo Base Editing as a Genetic Treatment for Spinal Muscular Atrophy
US National Institute of Neurological Disorders and Stroke · grant
Abstract Spinal muscular atrophy (SMA) is a devastating neuromuscular disease and a leading genetic cause of infantile death worldwide. Despite exciting progress in the neuromuscular field that has resulted in novel therapies, there remains…
Posted May 21, 2026
SORL1 and its involvement in Alzheimer's disease pathogenesis and pathophysiology - Project 4
US National Institute on Aging · grant
PROJECT 4 SUMMARY Recent genetic studies have established that rare loss-of-function mutations in the Sortilin-related Receptor 1 (SORL1) gene confer extremely high risk for developing Alzheimer’s disease (AD). Currently, over 500 known co…
Posted May 21, 2026
Targeting Endosomal dysfunction as a new source of biomarkers for Alzheimer's disease
US National Institute on Aging · grant
Endosomal dysfunction is a well-accepted cell biological feature in Alzheimer’s disease (AD). However, biomarkers reflecting endosomal traffic defects are still lacking. Current imaging and cerebrospinal fluid (CSF) AD biomarkers focus prim…
Posted May 21, 2026
Gut pathogen virulence and its therapeutic modulation during surgical injury
US · IL NIH · grant
1 We demonstrated in both mice and critically ill humans, that following surgical injury/infection, the gut 2 microbiota collapse in structure, membership and function (i.e., production of health-relevant metabolites) such 3 that both imm…
Posted May 21, 2026
In situ destruction of halogenated Superfund contaminants with biological radical reactions
US · IL NIH · NAICS 541714 · grant
PROJECT 3: SUMMARY/ABSTRACT Highly halogenated compounds include recently recognized pollutants such as per- and polyfluorinated alkyl substances (PFAS) as well as legacy contaminants, such as chlorinated solvents, polychlorinated biphenyls…
Posted May 21, 2026
The Developmental Transition of Neural Stem Cell Niches in the Human Brain
US National Institute of Neurological Disorders and Stroke · grant
Project Summary Our earlier work identified the neural stem cells (NSC) and intermediate progenitors that generate new neurons and glial cells in the adult mouse brain. These NSCs are regionally specified to produce unique sets of inhibitor…
Posted May 21, 2026
Synaptic mechanisms underlying reward seeking and compulsive drug use
US National Institute on Alcohol Abuse and Alcoholism · grant
Project title: “Early life adversity increases striatal density of dopamine D1 receptors and promotes social alcohol drinking in mice, especially males ” The brain’s reward circuitry remains sensitive to experience throughout early life an…
Posted May 21, 2026
Section on Neurobiology of Compulsive Behaviors
US National Institute of Mental Health · grant
Early life adversity increases striatal density of dopamine D1 receptors and promotes social alcohol drinking in mice, especially males: The brain’s reward circuitry remains sensitive to experience throughout early life and into adulthood,…
Posted May 21, 2026
Functional Mechanism of Neural Control in Post-Concussion Convergence Insufficiency
US National Eye Institute · grant
Project Summary/Abstract: During the past 6 years, our study team investigated the neural mechanism of typically-occurring convergence insufficiency (TYP-CI), the most common binocular vision disorder in children and young adults (3.4% to 1…
Posted May 21, 2026
Project 4: Pyrolytic conversion of PAHs in contaminated sediments into char to eliminate toxicity and enhance soil fertility
US · IL NIH · NAICS 541715 · grant
Project Summary There is a pressing need for more reliable and cost-effective remediation of contaminated soils and sediments at Superfund sites to mitigate exposure and protect public health. This project will develop a sustainable thermal…
Posted May 21, 2026
Unraveling alphavirus neuroinvasion: Molecular insights from a stem cell based blood-brain barrier model
US · CA · Los Angeles National Institutes of Health (NIH) · grant
PROJECT SUMMARY Alphaviruses are mosquito-borne viruses that can cause arthritis and fatal encephalitis in humans with no approved therapeutics. Encephalitic alphaviruses, like Sindbis (SINV) and chikungunya (CHIKV) viruses, must cross the …
Posted May 21, 2026
Rise to the Challenge Bridge to Health Informatics and Bioinformatics
US National Institute of General Medical Sciences · grant
The mission of the Rise to the Challenge Bridge to Health Informatics and Bioinformatics program is to continue providing the skills and resources for El Paso Community College (EPCC) students to successfully transfer to the University of T…
Posted May 21, 2026
How cell maturation is regulated by circadian and metabolic rhythms
US · IL National Institute of General Medical Sciences · grant
Project Summary/Abstract The overall goal of my research program is to mechanistically understand how circadian and metabolic rhythms shape how fully differentiated cells become functionally specialized, or “mature”. Cycles in energy availa…
Posted May 21, 2026
Mitochondrial influences on blood brain barrier function and neuropsychiatric illness
US · IL NIH · grant
Neuropsychiatric disorders are increasingly associated with neuroinflammatory processes. The blood-brain barrier (BBB) is a critical modulator of peripheral inflammatory influences on brain development and function. PIs Jorge Alvarez, a neu…
Posted May 21, 2026
Role of the brain-immune axis in neuropsychiatric disease
US · IL NIH · grant
The study of brain-immune interactions has contributed to a paradigm shift in the understanding of the pathophysiology of mental disorders and has provided new insights into their prevention and treatment. Notably, the blood-brain barrier (…
Posted May 21, 2026
A Dietary Intervention to Improve Glucose Tolerance in Adults with Cystic Fibrosis
US · IL NIH · NAICS 541715 · grant
PROJECT SUMMARY/ABSTRACT Successes in therapies for individuals with cystic fibrosis (CF) have exponentially improved survival in this population. There is now a critical need for better understanding of how to promote optimal long-term hea…
Posted May 21, 2026
Core 2, NLB
US · IL NIH · grant
Posted May 21, 2026
Par-4 Regulation of Actomyosin Contractility as a Tumor Suppressive Mechanism in Breast Cancer
US · IL NIH · grant
Project Summary/Abstract Tumor progression – including resistance to therapy, metastasis, and recurrence – is responsible for the majority of cancer deaths. Understanding how cancer cells survive treatment, spread to distant sites, persist …
Posted May 21, 2026