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20,086 contracts

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Showing 25 / 20086 · page 43/804
NRF2 suppression of inflammatory signaling and its role in tumor progression
US · IL NIH · grant
Project Summary/Abstract Tumor metastasis is responsible for the vast majority of deaths from epithelial cancers, including breast cancer. Understanding how cancer cells spread to distant sites, persist as dormant disseminated tumor cells …
Posted May 21, 2026
Development of Synaptic Inputs on Spinal Interneurons
US · IL NIH · grant
PROJECT SUMMARY (30-lines) Movement depends on patterned spinal cord motor output necessary for coordinated muscle actions. This in turn, depends on spinal interneuron microcircuits that modulate motoneuron recruitment and firing. The recen…
Posted May 21, 2026
Characterizing the formation and maintenance of drug-biased beliefs in opioid use disorder
US · IL NIH RePORTER · NAICS 541715 · grant
PROJECT SUMMARY/ABSTRACT Despite psychoeducational efforts highlighting consequences of opioid use, relapse remains common for individuals with opioid use disorder (OUD). This clinical observation indicates a need for better understanding h…
Posted May 21, 2026
Barriers and Facilitators for Delivery of Guideline-Concordant Care for Adolescents and Young Adults with Ewing Sarcoma and Osteosarcoma
US · IL NIH · grant
PROJECT SUMMARY / ABSTRACT Roughly 90,000 adolescents and young adults (AYAs: 15–39) are diagnosed with cancer in the United States each year. Disparities in cancer mortality exist among AYAs with Ewing sarcoma (EWS) and osteosarcoma (OS), …
Posted May 21, 2026
The Role of CD4+ Memory T cell Subtypes in Periodontal Disease Recurrence
US National Institute of Dental and Craniofacial Research · grant
Project Summary The recurrence of periodontal disease (PD) is a poorly immunologically defined or therapeutically targeted clinical challenge. Uncovering the homeostatic and pathogenic potential of long-term immune cells in periodontal tiss…
Posted May 21, 2026
Mechanisms of Immediate Non-IgE-mediated Drug Hypersensitivity Reactions (MIND-HR)
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Although IgE-mediated HSRs are the most feared, most drug HSRs are non-IgE-mediated and often require only dosage and administration adjustments rather than complete drug avoidance. Clinical similarities between IgE…
Posted May 21, 2026
Mechanisms of calcium-induced arrhythmias in arrhythmogenic right ventricular cardiomyopathy
US · IL NIH · grant
PROJECT SUMMARY / ABSTRACT Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a complex inherited disorder of the heart produced by mutation in proteins of the desmosome, such as plakophilin-2 (PKP2). Cardiac arrhythmias, and potenti…
Posted May 21, 2026
Identifying neurocognitive correlates of reading impacted by adversity exposure
US · IL NIH · grant
PROJECT ABSTRACT/SUMMARY Reading is a developmental process and a core component of education that depends on the acquisition, integrity, and processing efficiency of fundamental text-based, linguistic, and neurocognitive processes refined …
Posted May 21, 2026
Can Medicaid Managed Care mitigate race/ethnic health disparities in diabetes?
US National Institute on Minority Health and Health Disparities · grant
Modified Abstract Section This study represents a timely investigation that addresses differences in type 2 diabetes (T2DM) care using the most up-to-date encounter data post 2016 (ICD switch). T2DM is a burdensome chronic condition that d…
Posted May 21, 2026
Cytoskeletal force-sensing mechanisms
US National Institute of General Medical Sciences · grant
Cells perceive mechanical cues in their local environments, which must be converted into intracellular biochemical signals to modulate cellular physiology and control gene expression. This process of mechanical signal transduction (“mechano…
Posted May 21, 2026
Converting cytoskeletal forces into biochemical signals
US · IL NIH · NAICS 541715 · grant
PROJECT SUMMARY Cells perceive mechanical cues in their local environments, which must be converted into intracellular biochemical signals to modulate cellular physiology and control gene expression. There is increasing appreciation for me…
Posted May 21, 2026
Project 3: Cellular and molecular mechanisms underlying effects from early life exposure to HAB toxins
US · IL NIH · grant
The overall objective of the proposed research is to elucidate the cellular and molecular mechanisms of toxicity from developmental exposure to harmful algal bloom (HAB) toxins. The HAB toxins domoic acid (DA), saxitoxin (STX), and anatox…
Posted May 21, 2026
Career Enhancement Program
US National Cancer Institute · grant
The evolution of prostate cancer research is highly dependent on the addition of new investigators with fresh, innovative concepts to advance the field. In recognition of the need to help establish independently funded investigators in the …
Posted May 21, 2026
Developing New Treatment Strategies for Neuroendocrine Prostate Cancer
US National Cancer Institute · grant
Project Summary/Abstract Neuroendocrine prostate cancer (NEPC) is the most virulent form of the disease. Loss of the tumor suppressors TP53/RB1 is ubiquitous in NEPC, but molecular mechanisms that explain how loss of TP53/RB1 promotes NEPC…
Posted May 21, 2026
Targeting Early Drivers of Prostate Cancer Lineage Plasticity
US National Cancer Institute · grant
Lineage plasticity (LP)—most commonly exemplified by loss of androgen receptor (AR) signaling and switch from a luminal to an alternate differentiation program—is now recognized as a critical determinant of lethality. Most efforts in the fi…
Posted May 21, 2026
HIV Enhanced Access Testing in Emergency Department program using a Systems Analysis and Improvement Approach (HEATED-SAIA) Cluster Randomized Trial
US · IL NIH RePORTER · grant
There are ~38 million people living with HIV (PLH) globally, with the majority in low-and middle-income countries (LMICs). Incident infections are concentrated in sub-Saharan Africa and focused in difficult to reach populations, who also ha…
Posted May 21, 2026
Left-Right Organizer Cellular and Molecular Dynamics Drive Early Cardiac Asymmetries
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Abnormal development of the left-right (LR) axis during embryogenesis can manifest as a broad spectrum of severe congenital heart diseases (CHDs), a group of conditions that affects 1% of all infants and in which th…
Posted May 21, 2026
Improving quantitative accuracy and tissue visualization in CBCT guided radiation therapy
US National Cancer Institute · grant
PROJECT SUMMARY Even though cone beam computed tomography (CBCT) is the most commonly used volumetric image guidance modality, its role has been severely limited in the context of treatment monitoring and patient-specific treatment modific…
Posted May 21, 2026
Elucidate the landscape of druggable targets for eliminating cancer persister cells
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY Residual disease, caused by incomplete killing of cancer cell populations, is a critical limitation of targeted therapy, and almost inevitability leads to tumor recurrence. A growing body of evidence suggests a significant c…
Posted May 21, 2026
Age Related Hearing Loss and Vestibular Dysfunction
US · IL NIH · grant
Proposed studies are to test mechanism-based, clinically relevant interventions to meet the challenges of aging in the Veteran population. Hearing Loss is one of the most common service-related disabilities for those who served in the gulf …
Posted May 21, 2026
Novel mechanisms in the control of cAMP dynamics
US National Institute of General Medical Sciences · grant
GPCRs are the largest family of mammalian membrane receptors with an established relevance in therapy, representing a third of the currently FDA-approved drugs. Particularly GsPCRs via cAMP are involved in many physiological and pathophysio…
Posted May 21, 2026
Enhancing Solid Tumor lmmunotherapy with Targeted siRNA Delivery
US National Cancer Institute · grant
Abstract To address the significant challenges of immunotherapy for solid tumors, Absco Therapeutics (AbscoTx) has developed a novel intratumoral delivery system utilizing the Oncolymer™ platform. The need for new effective approaches to de…
Posted May 21, 2026
Lung Cancer Vaccine
US · IL National Institutes of Health (NIH) · grant
PROJECT SUMMARY Computerized chest tomography (CT) lung cancer screening programs have increased the detection of premalignant non-solid (NS) nodules that harbor preinvasive or minimally invasive adenocarcinoma. Given that NS nodules can…
Posted May 21, 2026
Defining virulence factor functions using minimal pathogen genomes
US · IL NIH · grant
Project Summary Pathogenic bacteria have developed an array of strategies to undermine the host's defense mechanisms. In the context of non-Typhoidal Salmonella Typhimurium, a notable strategy involves the confinement of a single bacterium …
Posted May 21, 2026
Oxysterol Regulation of Microbial Pathogenesis
US National Institute of Allergy and Infectious Diseases · grant
Project Summary The proposed project focuses on our recent discovery that immunological production of the oxysterol 25- Hydroxycholesterol (25HC) potently inhibits the cellular dissemination of two globally important bacterial pathogens, Li…
Posted May 21, 2026