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Showing 25 / 20086 · page 45/804
Reducing Stigma in People Who Inject Drugs with HIV Using a Rapid Start Antiretroviral Therapy Intervention
US John E. Fogarty International Center for Advanced Study in the Health Sciences · grant
HIV transmission continues in low- and middle-income countries (LMIC), especially among key affected populations (KAP) and in settings of high stigma and discrimination. In Malaysia, a LMIC in SE Asia, HIV incidence and mortality is increas…
Posted May 21, 2026
Georgian Implementation Science Fogarty Training Program (GIFT)
US · IL NIH · grant
Despite many available evidence-based interventions (EBIs) to prevent HIV, new infections and mortality in Georgia have increased by 30% and 335%, respectively. Georgia is a LMIC with HIV prevalence of 0.4% and concentrated in key at-risk p…
Posted May 21, 2026
Prison Interventions and HIV Prevention Collaboration
US · IL NIH · grant
Eastern Europe and Central Asia (EECA) have among the highest (5 of the top 10) incarceration rates worldwide, with staggering numbers of people who inject drugs (PWID), mostly with opioid use disorder (OUD: 82%) and HIV (PWH: 18%). The HIV…
Posted May 21, 2026
Malaysian Implementation Science Training (MIST) Program in HIV
US · IL NIH · grant
Despite an array of evidence-based interventions (EBIs) to address HIV - and the 95/95/95 strategy the HIV epidemic in Malaysia and Indonesia remains volatile. Malaysia's rapidly expanding HIV epidemic is the fifth largest in the Asia-Pacif…
Posted May 21, 2026
Innovations in Implementing Decentralized HIV Services in Peru
US · IL · Lima National Institutes of Health (NIH) · grant
Despite successes in diagnosing and initiating antiretroviral therapy (ART) in people with HIV (PWH) in Peru, a LMIC with an HIV epidemic concentrated in key at-risk populations, the implementation gap is highest for retention in care (RIC)…
Posted May 21, 2026
Integrating Addiction and Infectious Diseases Services into Primary Care in Rural Settings
US National Institute on Drug Abuse · grant
Abstract The US strategy to End the HIV Epidemic calls for expanded prevention of new infections and more effective responses to HIV outbreaks. These outbreaks often occur in counties and states that share a disproportional burden of HIV, b…
Posted May 21, 2026
Expanding Medication Assisted Therapies in Central Asia
US National Institute on Drug Abuse · grant
Central Asia (CA) represents the most rapidly growing HIV epidemic region worldwide, concentrated in people who inject drugs (PWID) and their sexual partners. Scaling up opioid agonist therapies (OAT) in CA is the most cost-effective strate…
Posted May 21, 2026
North American AIDS Cohorts on Collaboration and Design (NAACCORD)
US · IL NIH · grant
(no more than 30 lines) The North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) has represented Region 1 of the leDEA initiative since 2006. The >20 single and multi-site clinical and classical epidemiologic HIV coho…
Posted May 21, 2026
The role of Nrf2 in beta cell expansion during pregnancy
US · IL National Institutes of Health · NAICS 541714 · grant
Summary The late stages of the mammalian pregnancy are accompanied with increased insulin resistance due to the increased glucose demand of the growing fetus. Therefore, as a compensatory response, in order to maintain the maternal normal b…
Posted May 21, 2026
A Rigid Body Database On Human Movement
US · IL NIH · grant
The primary objective of this study remains the same: to link the neuro-muscular system and movement biomechanics of people with and without physical impairments to his or her ability to perform activities of daily living, including gait. M…
Posted May 21, 2026
Integrating brain and behavioral measures of central pain inhibition to personalize treatment in chronic pain management
US National Institute of Neurological Disorders and Stroke · grant
Although pain inhibition by the central nervous system (CNS) strongly modulates acute pain in the lab, its relevance for patient outcomes is less well known. Studies with animal models, human behavioral paradigms, and neuroimaging have impl…
Posted May 21, 2026
Leveraging inter-individual differences in walking pain and impairment to elucidate whole-person mechanisms of knee osteoarthritis
US · IL NIH · grant
Project Summary/Abstract Knee osteoarthritis (OA) is a common and debilitating condition, affecting millions in the United States of America. From 1990 to 2020, OA ranked as the 14th highest cause of age-adjusted years lived with disability…
Posted May 21, 2026
Decoding viral transmission, tropism and inflammation: from single cell to organism
US National Heart Lung and Blood Institute · grant
Inflammation is activation of the immune system. It plays an important role for fighting infectious pathogens but unregulated contributes to the development of many childhood and adult chronic diseases including cardiovascular disease, art…
Posted May 21, 2026
Immunophenotyping by high-dimensional cytometry and machine learning
US · IL NIH · grant
We recently transitioned to spectral flow cytometry (instead of mass cytometry): this is faster, cheaper, more reliable, high-througput experimental techniques with no downside in terms of the measurement quality. We have also introduced a …
Posted May 21, 2026
Dynamics of hematopoietic differentiation
US National Cancer Institute · grant
We finalized a manuscript detailing our most recent experimental results and modeling effort. This paper was submitted to biorxiv and is being adjusted to address reviewers' comments. Homeostatic hematopoiesis is a dynamical process, charac…
Posted May 21, 2026
Dynamics of viral infection
US · IL NIH · NAICS 541714 · grant
Our recent projects pivoted from immune responses to coronaviruses to the more fundamental aspects of host/pathogen interactions namely the tug-of-war between viral replication and innate immune response at the individual cell level. Cytoso…
Posted May 21, 2026
Phenotypic variability within isogenic population of lymphocytes
US National Cancer Institute · grant
We expanded the project horizon by collaborating with Naomi Taylor (CCR) and Paul François (UMontréal) in order to usher new Chimetic Antigen Receptor (CAR) T cells. CAR T cell therapy has been transformative for blood cancers but remains l…
Posted May 21, 2026
Mechanisms driving cardiac dysfunction in Autosomal Dominant Polycystic Kidney Disease
US · IL NIH · grant
Cardiovascular disease is a major cause of morbidity and mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Characterized by progressive renal dysfunction, ADPKD imposes very significant healthcare and economic…
Posted May 21, 2026
Fostering Underrepresented Employees' Resilience and Zeal for Academia (FUERZA)
US · IL NIH (National Institute on Deafness and Other Communication Disorders - NIDCD) · grant
Project Summary/Abstract The broad, long-term objectives of the Fostering Underrepresented Employees’ Resilience and Zeal for Aca- demia (FUERZA) project are three-fold. The first is to enhance diversity in NIDCD’s extramural workforce by c…
Posted May 21, 2026
Mechanisms That Control Antigen Receptor Variable Region Exon Assembly
US · IL NIH · grant
7. Project Summary/Abstract. During the past funding period, we discovered that the cohesin-mediated loop extrusion process involved in genome-wide modulation of chromosome architecture plays fundamental roles in V(D)J recombination and th…
Posted May 21, 2026
Mechanisms that Regulate Antibody Class Switch Recombination and Somatic Hypermutation
US · IL NIH · grant
Project Summary/Abstract of Research Plans for the Extension Period The first two specific aims of this R37 grant were to test our hypothesis that cohesin-mediated loop extrusion plays a key role in lgH class switch recombination (CSR) and …
Posted May 21, 2026
Coordinated responses to host-derived stresses in C. neoformans
US National Institute of Allergy and Infectious Diseases · grant
SUMMARY Although potent antifungal agents are currently available, invasive fungal infections remain highly prevalent causes of disease and death, especially in our most vulnerable patients with defective immune systems. AIDS, organ transp…
Posted May 21, 2026
Copper homeostasis in fungal pathogenesis
US · IL NIH · grant
SUMMARY Copper (Cu) is an essential trace element and a catalytic cofactor for a variety of enzymes involved in cell growth, development, and stress resistance. Fungal systems have been instrumental in identifying mechanisms of Cu utilizat…
Posted May 21, 2026
Advancing KNX100 for the treatment of opioid withdrawal: preclinical efficacy and toxicology, and a phase 1 clinical program.
US National Institute on Drug Abuse · grant
Application Identifier: 364510 Application Project Title: Advancing KNX100 for the treatment of opioid withdrawal: preclinical efficacy and toxicology, and a phase 1 clinical program. Project Summary/Abstract Kinoxis Therapeutics Pty Ltd is…
Posted May 21, 2026
EAT: A Reliable Eating Assessment Technology for Free-living Individuals.
US · IL National Institute of Diabetes and Digestive and Kidney Diseases · grant
Project Summary/Abstract Overeating and unhealthy eating are often associated with various health risk conditions such as obesity, high blood pressure, and some chronic diseases. To get a better understanding of overeating and unhealthy eat…
Posted May 21, 2026