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Showing 25 / 20086 · page 46/804
PASSPORT: PASsive Sensing to Prevent stress-related Overeating in Real-Time
US National Heart Lung and Blood Institute · grant
Project Summary/Abstract Stressful events, overeating, and obesity have been associated with cardiovascular disease (CVD). Characterizing the relationship between these factors may inform targeted and timely interventions to prevent overeat…
Posted May 21, 2026
SESAME: Sun Exposure and Activities after Skin CAncer: Optimization of Mhealth IntErventions
US National Cancer Institute · grant
ABSTRACT There are currently 1.36 million melanoma survivors in the US, and this number is expected to increase to 1.92 million by 2030. Most melanoma patients (92%) survive 5 or more years but face an increased risk of new primary melanoma…
Posted May 21, 2026
Elucidating the role of FBLL1 in ribosome function during neuronal differentiation
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
PROJECT SUMMARY Chemical modifications of RNA have been seen to have numerous biological consequences including regulation of development. Ribosomal RNA is heavily modified by 2’O methylation (2’O-Me). There is increasing evidence that regu…
Posted May 21, 2026
ECHO-PROTECT Cohort Study Site in Puerto Rico
US · IL National Institutes of Health · grant
The effect of early environmental exposures on child health and development is an important area of public health that no single cohort, or even a few, can answer alone. Determining this effect becomes more challenging when considering that…
Posted May 21, 2026
Biomechanics of the Human Brain During High-Severity Impacts: A Multimodal Approach
US · IL NIH · grant
Project Summary Traumatic brain injury (TBI) is a significant health care problem, affecting over 2.5 million people in the United States annually. Most cases are classified as mild or concussive TBI, caused by a rapid acceleration to the s…
Posted May 21, 2026
Cannabis use and cardiovascular health outcomes among patients with high blood pressure
US · IL National Institutes of Health · grant
ABSTRACT In recent years, cannabis, and its constituents (delta-9 tetrahydrocannabinol [THC] and cannabidiol [CBD]) have been promoted as natural remedies, with chronic disease patients as prominent marketing targets. Consequently, adults w…
Posted May 21, 2026
Multi-tissue type condensations for trachea tissue regeneration via individual cell bioprinting
US Veterans Affairs · grant
Abstract As a result of prolonged intubation, tracheostomy, external trauma, penetrating fragment projectiles, gunshot wounds and improvised explosive devices during combat, and benign or malignant tumors, many soldiers and veterans in the …
Posted May 21, 2026
In situ bioprinting of high-density cell-laden core-shell microgel bioinks enabling cellular condensation for vascularized bone tissue regeneration
US · IL NIH RePORTER · grant
Abstract Bone damage and loss resulting from combat associated penetrating fragment projectiles, gunshot wounds and improvised explosive devices are some of the most common injuries US Military personnel experience and contribute to increas…
Posted May 21, 2026
Individual cell bioprinting to generate multi-tissue type condensations for osteochondral tissue regeneration
US · IL NIH · grant
Abstract Osteochondral defects of the knee are common worldwide, yet there are few viable options for patients with damaged osteochondral tissue as current treatments do not consistently regenerate functional tissue. The standard of care fo…
Posted May 21, 2026
Regulation of Intestinal Bile Acid Absorption in Health and Cholesterol-Related Disorders
US Veterans Affairs · grant
The ileal apical sodium-dependent bile acid transporter (ASBT) is crucial for the enterohepatic circulation of bile acids and plays a key role in maintaining bile acid, lipid, and cholesterol balance. Emerging evidence suggests that ASBT is…
Posted May 21, 2026
Machine learning of biomolecular interactions and the human signaling networks they comprise
US National Institute of General Medical Sciences · grant
My lab will use machine learning to build physically-grounded models of biomolecules and their interactions and apply these models at proteome (genome) scale to address basic questions in the systems biology of human signaling. On the model…
Posted May 21, 2026
Fast and slow prediction of stable and transient protein-protein interactions
US National Library of Medicine · grant
Protein-protein interactions (PPIs) underpin processes ranging from transduction of signaling networks to maintenance of cellular structure. Identifying new human PPIs may uncover interactions targetable by PPI- modulating drugs, while iden…
Posted May 21, 2026
Developing a redox-mediated single NP detection for bioconjugate analysis.
US National Institute of General Medical Sciences · grant
Although immunoassays are a critical part of bioanalytical chemistry, the rapid and selective analysis of biomolecules continues to be a complicated aspect of biomedical research. The long-term goal is to develop single-entity electrochemis…
Posted May 21, 2026
BLR&D Research Career Scientist Award
US Veterans Affairs · grant
Bile duct epithelial cells (i.e., cholangiocytes) are the target cells in cholangiopathies such as primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and cholangiocarcinoma (CCA), which are diseases characterized by th…
Posted May 21, 2026
IND-enabling studies for eCD4-Ig as a long-acting recombinant protein therapeutic
US · IL NIH · NAICS 541714 · small business · grant
ABSTRACT This FastTrack SBIR grant will support pre-clinical IND-enabling studies for recombinant eCD4-Ig protein, ahead of a first-in-human (FIH) Phase 1 clinical trial. eCD4-Ig is an antibody-like therapeutic for HIV consisting of parts …
Posted May 21, 2026
Process development for manufacturing eCD4-Ig
US · IL NIH · grant
ABSTRACT eCD4-Ig is an antibody-like therapeutic for HIV that was constructed by fusing CD4 domains 1 and 2, and an HIV coreceptor-mimetic sulfopeptide, to the N- and C-termini of the constant Fc region of an antibody. eCD4-Ig will join an…
Posted May 21, 2026
SARS-CoV-2 vaccines based on RBDs with engineered glycosylation sites
US National Institute of Allergy and Infectious Diseases · grant
 We are developing vaccine antigens for SARS-CoV-2 that focus the antibody response onto neutralizing epitopes in the receptor binding domain (RBD) of the viral Spike (S) protein. Booster antigens derived from variants of SARS-CoV-2 would e…
Posted May 21, 2026
Developing shared medical appointments for informal caregivers of Alzheimer’s and Dementia patients to improve knowledge, communication, and advanced planning
US · IL NIH RePORTER · grant
Project Summary The prevalence of Alzheimer's Disease and related Dementias (ADRD) is expected to triple by 2060, affecting about 14 million Americans. As ADRD progresses, symptoms worsen, putting informal caregivers (ICs) in charge of tend…
Posted May 21, 2026
A Multimodal Parent-focused Intervention for Vulnerable Populations in the Bronx
US National Institute of Mental Health · grant
PROJECT SUMMARY / ABSTRACT In response to PAR-20-237, “community interventions to address the consequences of the COVID-19 pandemic among health disparity and vulnerable populations,” we propose to study a parent-focused mentalizing interve…
Posted May 21, 2026
Enhancing PTSD Treatment Outcomes by Improving Patient-Provider Communication
US · MA · Boston National Institutes of Health (NIH) · grant
Project Summary/Abstract Posttraumatic stress disorder (PTSD) is a debilitating condition with deleterious effects on individuals and society. Evidence-based treatments for PTSD are available, including cognitive processing therapy (CPT) an…
Posted May 21, 2026
Vibrational Sensing in Super-Resolution Two-Dimensional Infrared Imaging
US National Institute of General Medical Sciences · grant
Project Summary Vibrational Sensing in Super-Resolution Two-Dimensional Infrared Imaging Many amyloidogenic peptides are implicated in diseases ranging from Alzheimer’s to diabetes to cardiomyopathy. Chaperone proteins such as HSP27 and αB-…
Posted May 21, 2026
Mechanisms and Impact of Pregnancy-Induced Adaptations in Pelvic Floor Muscles
US · IL NIH · grant
PROJECT SUMMARY Our proposal exemplifies the NIH vision that the multidisciplinary approach to clinical care and research is the most fruitful paradigm for the development of significant advancements within a specific field. While it is unf…
Posted May 21, 2026
Regenerative biomaterial for combating genitourinary syndrome of menopause
US · IL NIH · NAICS 541714 · grant
Project Summary Genitourinary syndrome of menopause (GSM) is an extremely prevalent condition consequent to the hypoestrogenic changes in the genitourinary tract that affects up to 85% of perimenopausal and menopausal women. Major symptoms …
Posted May 21, 2026
MDS-associated U2AF1 mutations induce natural killer cell dysfunction
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Therapeutic approaches that harness the immune system to target tumors are revolutionizing the cancer treatment field. Natural Killer (NK) Cells are innate lymphocytes that regulate inflammatory and immune responses…
Posted May 21, 2026
MDS-Associated Spliceosome Mutations Regulate Host Defense
US · IL NIH · grant
ABSTRACT Myelodysplastic Syndrome (MDS) is a hematopoietic stem cell disorder characterized by myeloid cell differentiation defects and dysplastic blood cell production. The majority of MDS patients die of disease related causes, with infec…
Posted May 21, 2026