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Showing 25 / 20086 · page 47/804
The role of alpha-adrenergic vasoconstriction on blood flow to exercising skeletal muscle in patients with heart failure with preserved ejection fraction
US · IL NIH · grant
Heart Failure (HF) is a leading cause of hospitalization and mortality among older adults in America1. Veterans, in particular, appear to have a greater risk of developing HF than non-Veterans and hospital readmission rates of Veterans are …
Posted May 21, 2026
ErythroMer: Nanoscale BioSynthetic Red Cell Substitute
US National Heart Lung and Blood Institute · grant
Research Summary/Abstract ErythroMer (EM) is a novel biosynthetic blood substitute developed to address the critically unmet need for emergency transfusion in situations where the use of banked red blood cells (RBCs) are either not availabl…
Posted May 21, 2026
Eicosanoid Pathways Underlying Disease Risk in Pulmonary Arterial Hypertension
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY/ABSTRACT The objectives of this K08 proposal are to foster the development of critical scientific and professional skills that will allow the candidate, Dr. Mona Alotaibi, to advance toward her goal of becoming an independen…
Posted May 21, 2026
Blood Biomarker Development and Validation in Chronic Traumatic Encephalopathy and Alzheimer's Disease and Alzheimer's Disease Related Dementias
US · IL NIH · grant
Each year, millions of people are exposed to repetitive head impacts (RHI) through contact sports, military service, and physical violence. These impacts can confer risk for Alzheimer’s disease (AD) and related dementias (ADRD) including ch…
Posted May 21, 2026
Risk and Resilience, Clinical presentation, and Biomarker Profiles of Chronic Traumatic Encephalopathy and Related Dementias: The DIAGNOSE CTE Research Project II
US · IL National Institute of Neurological Disorders and Stroke (NINDS) / National Institutes of Health (NIH) · grant
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease diagnosed postmortem in people exposed to repetitive head impacts (RHI) from football and other contact sports. NINDS consensus research diagnostic criteria for the clini…
Posted May 21, 2026
Risk for Later-Life Cognitive Impairment, Neurobehavioral Dysregulation, and Dementia in Former Soccer and American Football Players: The Head Impact and Trauma Surveillance Study (HITSS)
US · IL NIH · grant
Exposure to repetitive head impacts (RHI) through participation in contact and collision sports (CCS) can result in symptomatic concussions and asymptomatic subconcussions and may increase risk for later-life cognitive decline and neuropsyc…
Posted May 21, 2026
Late Pathologies of Exposure to Repetitive Head Impacts from Contact Sports: White Matter and Vascular Contributions to Cognitive Impairment, Dementia, and Neuropsychiatric Symptoms
US · IL NIH · NAICS 541715 · grant
Each year, millions of Americans are exposed to repetitive head impacts (RHI) through contact sport participation and may be at risk for chronic traumatic encephalopathy (CTE). The clinical presentation of CTE is ill-defined and includes de…
Posted May 21, 2026
Children's Oncology Group Statistics and Data Center
US · IL National Cancer Institute (NCI) · grant
PROJECT SUMMARY Since the introduction of chemotherapy for the treatment of childhood leukemia more than 60 years ago, the prognosis of childhood cancer has improved dramatically. The overall 5-year survival rate for childhood cancers, many…
Posted May 21, 2026
Children's Oncology Group
US · IL National Cancer Institute (NCI) · grant
PROJECT SUMMARY Since the introduction of combination chemotherapy for the treatment of childhood leukemia more than 60 years ago, the prognosis of childhood cancer has improved dramatically. The 5-year survival rate for childhood cancers, …
Posted May 21, 2026
A Dynamic and Three-Dimensional Human Model of Hypoplastic Left Heart Syndrome to Probe Compromised Cardiomyocyte Proliferation
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Hypoplastic left heart syndrome (HLHS) is a severe congenital heart defect in which the left side of the heart is underdeveloped, with structural malformations to the ascending aorta, aortic/mitral valves, and a cha…
Posted May 21, 2026
The non-canonical Collagen I-DDR1 signaling regulating protein synthesis during metastasis
US · IL NIH · grant
PROJECT SUMMARY The activation of signaling tumor cells via the tumor micrenvironment (TME) to undergo metastasis in bladder cancer is understudied. Clinically, increased Col I deposition correlates with bladder cancer progression (i.e. inc…
Posted May 21, 2026
Staphylococcus aureus Survival During Nutrient Restriction and Suppression of Host Immunity.
US National Institute of Allergy and Infectious Diseases · grant
Project Summary Staphylococcus aureus is a leading cause of nosocomial infection in the United States and is a predominant pathogen in communities. S. aureus survives during infection by subverting immune defenses and adapting to host-impos…
Posted May 21, 2026
Bacterial lipases and adaptation to the host lipid environment
US National Institute of Allergy and Infectious Diseases · grant
Project Summary The host lipid environment is a well-described barrier to bacterial infection at several sites including the skin, lung, and upper airways. In addition, both bacterial and host lipids serve as signals that promote inflammati…
Posted May 21, 2026
Bacterial cell wall remodeling, innate immunity, and pathogenesis
US · IL NIH · grant
Project Summary Infections caused by Staphylococcus aureus remain one of the most significant burdens to human health with ~750,000 associated deaths worldwide reported in 2019; a third of which were directly attributed to antimicrobial res…
Posted May 21, 2026
Benefits and harms of activating ATF6 in beta cells
US · IL NIH · grant
ABSTRACT Pancreatic beta cell insulin production is the critical lynchpin that determines diabetes resistance or susceptibility. ER stress is one cause of beta cell dysfunction and failure, not only in T2D but also in T1D and some forms of …
Posted May 21, 2026
Research Training in Endocrinology and Metabolism
US · IL NIH · NAICS 611310 · grant
PROJECT SUMMARY This proposed postdoctoral training program (2 fellows/year, 2-year program) in endocrinology and metabolism will provide comprehensive research training for individuals with a serious commitment to a career at the interface…
Posted May 21, 2026
Neuronal mechanisms of image processing in the early visual pathway
US · IL National Institutes of Health (NIH) · grant
PROJECT SUMMARY Images captured by our eyes are processed in the retina by separate ON and OFF pathways that signal light and dark stimuli in visual scenes. The traditional thinking is that the two pathways converge in visual cortex and the…
Posted May 21, 2026
Pediatric Acute Liver Failure Immune Response Network (PALF IRN): Treatment for Immune Mediated Pathophysiology (TRIUMPH)
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Project Summary Pediatric Acute Liver Failure (PALF) is a rare, devastating condition that affects an estimated 250 children per year in North America, causing death in approximately 15% and the need for liver transplantation (LT) in an add…
Posted May 21, 2026
Targeting regenerative reprogramming in colorectal cancer
US · NY NIH · grant
ABSTRACT Poorly defined fitness features enable a subset of cancer cells to survive therapy, ultimately giving rise to treatment-refractory tumors. The expanded use of sequencing tools have led to the recognition that refractory tumors ofte…
Posted May 21, 2026
Teachers and Students for Community-Oriented Research and Education: Linking Industry Partners, Faculty, and Teachers (TSCORE LIFT)
US National Institute of General Medical Sciences · grant
21st-century changes in healthcare have rapidly outpaced advancements in science education, leaving many high school students without access to high-quality, experiential science learning essential for preparing future health professionals.…
Posted May 21, 2026
Mapping the Functional and Anatomical Pathways from the Anterior and Posterior Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens: Implications for Opioid Use
US · IL NIH · grant
PROJECT ABSTRACT Opioid Use Disorder (OUD) is a complex medical condition characterized by compulsive and maladaptive use of opioid substances, including prescribed pharmaceuticals (such as oxycodone) and illegal agents (such as heroin). It…
Posted May 21, 2026
Maternal immune activation remodeling of offspring glycosaminoglycan sulfation patterns during neurodevelopment
US · IL NIH · grant
ABSTRACT Maternal immune activation (MIA) during prenatal or postnatal development significantly increases the risk for offspring neurodevelopmental disorders (NDDs) later in life. Growing evidence suggest that regardless of the MIA stimuli…
Posted May 21, 2026
Absolute Brain Thermography using Multinuclear MRI
US · IL NIH RePORTER · grant
PROJECT SUMMARY Stroke is the leading cause of disability, the second leading cause of dementia, and the second leading cause of death worldwide, affecting nearly 800,000 patients per annum in the U.S. alone. Cerebrovascular ischemia is ra…
Posted May 21, 2026
Biological role and pharmacology of EXPERA family proteins and their effect onsterol homeostasis
US National Institute of General Medical Sciences · grant
Abstract EXPERA are a family of membrane proteins that include sigma-2 receptor and TM6SF2, both of which play crucial yet understudied roles in cholesterol metabolism and disease. Sigma-2, an enigmatic membrane receptor implicated in cance…
Posted May 21, 2026
Neuroimaging of Instrumental Learning Networks in Adolescent Cannabis Use Treatment
US National Institute on Drug Abuse · grant
PROJECT SUMMARY/ABSTRACT The candidate’s long-term goal is to shift his research focus from examining neural correlates of individual differences in adolescent substance use disorders toward neurobiological predictors of individual treatme…
Posted May 21, 2026