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Showing 25 / 20086 · page 48/804
Novel Spatial-Motor Approaches Targeting Post-Stroke Spatial Neglect and Gait Deficits
US · IL NIH RePORTER · grant
PROJECT SUMMARY/ABSTRACT Aiming spatial neglect (SN) is a sub-type of SN that is a dysfunction in initiation/execution of motor–intentional behavior. SN components such as directional hypokinesia, turning behavior, weight-bearing asymmetry,…
Posted May 21, 2026
Caspase-1 Activation by the Inflammasomes
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Inflammasomes are multi-protein complexes that assemble to activate caspase-1 in response to tissue damage and infection by microbial or viral pathogens. Once activated, caspase-1 processes the inactive proforms of interleukin-1β (IL-1β) an…
Posted May 21, 2026
Investigating Novel HIV Reservoirs in the Pulmonary Vasculature
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY Infections with Human Immunodeficiency Virus (HIV) remain a major global public health concern. The HIV reservoirs are a leading reason for which HIV infection remains without a cure. HIV integrates its viral DNA into the ho…
Posted May 21, 2026
Role of HIV gp120 and Nef in Transcriptome Dysregulation and Pulmonary Vascular Remodeling
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY People living with HIV (PLWH) are at a significantly high risk of developing Pulmonary Hypertension (PH), which can lead to death by heart failure, even with the suppressive effects of antiretroviral therapy (ART). PH is ch…
Posted May 21, 2026
MI-SMART: Methods for Optimizing Multilevel Adaptive Implementation Strategies to Promote the Adoption of Effective SUD and HIV Services
US National Institute on Drug Abuse · grant
PROJECT SUMMARY: PROJECT 1 Evidence-based prevention, treatment, and recovery services for substance use disorders (SUDs) and HIV often fail to be implemented or sustained due to barriers at multiple levels, such as lack of time and skills …
Posted May 21, 2026
Dissecting enzyme function at scale using synergistic advances in microfluidics and genetic code expansion
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY. Noncanonical amino acids (ncAAs) have myriad valuable applications in the biochemical and biophysical sciences. Their site-specific incorporation into proteins of interest can directly install systematically perturbed resi…
Posted May 21, 2026
Defining the therapeutic efficacy, tolerogenic potential, and genotoxicity of liver-targeted AAV gene therapy for hemophilia A
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY: Gene therapy (GT) for the hemophilias is poised to fulfill the promise of a safe, affordable, lifelong correction following a single treatment. Yet clinical trials employing AAV vectors to treat adult hemophilia A (HA) pati…
Posted May 21, 2026
Using human liver tissue equivalents to optimize AAV-mediated GT and better define age-related clinical risks
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY Gene therapy (GT) clinical trials using AAV vectors are poised to fulfill the promise of a safe, affordable, lifelong correction of bleeding disorders following a single treatment. Still, clinical trials using AAV vectors to…
Posted May 21, 2026
Targeted conditioning to maximize prenatal HSC engraftment for SCD
US · IL NIH · grant
PROJECT ABSTRACT: Treatment of genetic disorders by in utero transplantation (IUTx) has safely been performed for decades in humans. The first IUTx cure, in the US, used hematopoietic stem cells (HSC) and corrected a child with X-SCID. Sinc…
Posted May 21, 2026
Different consequences of cellular aging in cortical versus cancellous bone- Resubmission
US · IL NIH · grant
Project Summary/Abstract Aging is responsible for the majority of fractures in both women and men. The cellular changes in the skeleton of aged mice are similar to those observed in aged humans. In mice, trabecular bone loss is associated w…
Posted May 21, 2026
Antagonism of RANKL signaling by estrogen in osteoclasts
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Loss of estrogens at menopause is a major cause of osteoporosis due to an increase in number and activity of the cells that resorb bone called osteoclasts. Estrogens inhibit bone resorption in part via direct effect…
Posted May 21, 2026
UIC Center for Healthy Work
US · IL UIC Center for Healthy Work · grant
ABSTRACT The UIC Center for Healthy Work’s (CHW) aims to identify and promote employment programs, practices, and policies that will improve worker and community health. Our vision is a future of work that promotes inclusive and equitable o…
Posted May 21, 2026
Predictive modeling of CD-68 inflammatory and anti-inflammatory chromatin packing domains for personalized biomarker discovery
US · IL National Institutes of Health · grant
Project Summary/Abstract Ulcerative colitis (UC) is a complex disorder impacting millions of people worldwide resulting in significant costs, chronic debilitating symptoms, and complications such as colon cancer. Even with biologic therapie…
Posted May 21, 2026
Administrative Core
US National Institute of Dental and Craniofacial Research · grant
The Administrative Core of CREATE serves as the foundation for the Center’s operations, providing comprehensive oversight, strategic coordination, and seamless integration of activities across all cores and member institutions. It ensures e…
Posted May 21, 2026
TMJ Disc Regeneration
US National Institute of Dental and Craniofacial Research · grant
Patients opting for TMJ disc removal face issues due to the absence of FDA-approved replacements, leading to bone-to-bone contact and subsequent joint problems. Autografts, like dermis-fat grafts, typically resorb within a year. Our goal is…
Posted May 21, 2026
Clinical Impact and Feasibility of Virtual Reality (VR) for Irritable Bowel Syndrome: A Pilot Randomized Controlled Trial Comparing VR Cognitive Behavioral Therapy vs. Sham VR
US · IL NIH · grant
PROJECT SUMMARY This proposal aims to conduct a pilot randomized controlled trial (RCT) to test the clinical impact and feasibility of a virtual reality (VR) cognitive behavioral therapy (CBT) program vs. sham VR among patients with irritab…
Posted May 21, 2026
The role of macrophage subpopulations in the rejuvenation of fracture repair
US National Institute on Aging · grant
The pace of bone repair slows with aging, increasing the chance of developing a delayed union or non-union. These complications are treated with surgical procedures causing significant morbidity and even mortality, especially in older adult…
Posted May 21, 2026
Molecular Etiology of Enchondromatosis
US · IL NIH · NAICS 541714 · grant
Abstract More than 3% of the population develops an enchondroma (ECA), a benign tumor in bone composed of cells derived from the growth plate that can cause pain, deformity, and can be responsible for pathologic fractures. Enchondromas can …
Posted May 21, 2026
Targeting the metastasis initiating cell in undifferentiated pleomorphic sarcoma
US National Cancer Institute · grant
Undifferentiated pleomorphic sarcoma (UPS) is a soft tissue sarcoma, with one of the worst prognosis. We will build on our discovery that UPS contains a small subpopulation of metastasis initiating cells (MCs) that are enhanced for their ab…
Posted May 21, 2026
Stem Cell Dysfunction in Aged Skeletal Muscle
US · IL NIH · grant
Abstract One of the greatest mysteries in ageing biology is to understand why many tissues and organs in our body, including skeletal muscle, decline in function as we get older? Recent studies suggest that the inability of muscle stem cell…
Posted May 21, 2026
Investigating the link between pericyte dysfunction and loss of glucose homeostasis in COVID-19
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
ABSTRACT The coronavirus disease 2019 (COVID-19) is a global healthcare crisis that in the USA kills about 1 person every minute. It is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). While respiratory failure is…
Posted May 21, 2026
Targeted Awareness and Education on Options in Uterine Fibroids
US · IL NIH · NAICS 541720, 611710 · grant
PROJECT SUMMARY – PROJECT 1 Non-Hispanic Black, African American (BAA) women have a 2 to 3 times higher uterine fibroid incidence rate compared to non-Hispanic White women. BAA women report experiencing higher disease burdens compared to no…
Posted May 21, 2026
A novel pediatric prosthetic foot for functional multi-axial mobility during active play
US · IL National Institutes of Health (NIH) · NAICS 339113 · small business · grant
Project Summary The goal of this Small Business Innovation Research (SBIR) development project is to establish technical merit, feasibility, and potential to commercialize a mechanical prosthetic foot- ankle with normalized ankle range of …
Posted May 21, 2026
Neural basis of precedence-type sound localization processes
US · IL NIH · grant
Project Summary This research project aims to study the neural basis of the precedence-type sound localization processes, including the Franssen effect. This central computation is key to understanding the normal function of auditory percep…
Posted May 21, 2026
Targeted degradation of CDK4 and 6 to overcome treatment resistance in breast cancer
US · IL National Institutes of Health (NIH) · grant
Abstract Although CDK4/6 inhibitors (in combination with an endocrine therapy) are the preferred systemic therapy for treatment of patients with metastatic, Estrogen Receptor-positive (ER+) breast cancer (BC), development of resistance to C…
Posted May 21, 2026