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20,086 contracts

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Showing 25 / 20086 · page 52/804
Deploying Histotripsy Based Tumor Ablation Strategies to Treat Pancreatic Cancer
US National Cancer Institute · grant
PROJECT SUMMARY: Pancreatic cancer accounts for approximately 3% of all cancers in the United States and approximately 7% of all cancer related deaths. New treatment paradigms are direly needed. Emerging tumor ablation techniques have shown…
Posted May 21, 2026
Optimization of High Frequency Irreversible Electroporation (H-FIRE) for tumor ablation and immune system activation in pancreatic cancer applications
US National Cancer Institute · grant
PROJECT SUMMARY: Pancreatic cancer accounts for approximately 3% of all cancers in the United States and approximately 7% of all cancer related deaths. New treatment paradigms are direly needed. Emerging tumor ablation techniques have shown…
Posted May 21, 2026
Neuropeptide Y1 Receptor-Expressing Neurons in the Lateral Parabrachial Nucleus in Neuropathic Pain
US National Institute of Neurological Disorders and Stroke · grant
Project Summary Pain is a complex phenomenon that elicits somatosensory and motor reflexive responses together with marked and long-lasting changes in emotional and autonomic states. While acute pain provides protection from tissue damage, …
Posted May 21, 2026
Developing novel CAR T cell designs using combinatorial antigen detection
US National Cancer Institute · grant
PROJECT SUMMARY/ABSTRACT Candidate: The applicant, Greg Allen, MD/PhD, is a medical oncologist at UCSF with a long-term goal to lead an independent laboratory-based translational research program focused on cellular therapies. The K08 appli…
Posted May 21, 2026
Project 2 - The marine microbiome as a source for the synthesis, transformation, and distribution of seafood contaminants
US National Institute of Environmental Health Sciences · grant
Project 2 – Summary/Abstract Seafood is a major dietary source of diverse chemical pollutants, especially for populations who rely on seafood as their primary protein source. Despite industrial chemicals such as PBDE fire retardants, the i…
Posted May 21, 2026
Functional and structural characterization of human auditory cortex using high resolution MRI
US National Institute on Deafness and Other Communication Disorders · grant
PROJECT SUMMARY A more complete characterization of auditory cortical processing in humans is critical to understanding auditory perception and cognition. Without it, developing effective treatment options for various auditory processing de…
Posted May 21, 2026
Down Syndrome Clinical Cohort Coordinating Center (DS-4C) for the INCLUDE Project
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY/ABSTRACT The overarching goal of the proposed INCLUDE Clinical Cohort Coordinating Center (DS-4C), co-led by investigators at RTI International and Emory University, is to improve the health and well-being of individuals wit…
Posted May 21, 2026
Project 3- FXPOI: Mechanisms and Modifiers
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Abstract - Project 3 Up to an estimated 1 in 151 women carry a fragile X premutation (PM) allele, impacting over one million women in the US. In addition to being at risk for having a child with fragile X syndrome (FXS), the most common gen…
Posted May 21, 2026
NICEATM Support Contract: Optional Level of Effort
US National Institute of Environmental Health Sciences · grant
"This is a Research and Development (R&D) contract to provide scientific and administrative support for the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). NICEATM rese…
Posted May 21, 2026
NICEATM Support Contract: Base Contract
US National Institute of Environmental Health Sciences · grant
"This is a Research and Development (R&D) contract to provide scientific and administrative support for the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). NICEATM rese…
Posted May 21, 2026
NICEATM Support Contract: Meeting Support and Contract Travel
US National Institute of Environmental Health Sciences · grant
"This is a Research and Development (R&D) contract to provide scientific and administrative support for the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). NICEATM rese…
Posted May 21, 2026
PQBP1 as a central regulator of inflammation in neurodegenerative diseases
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY: Neurodegenerative diseases pose significant challenges to public health and our understanding of brain function. Central to these conditions is the pathological accumulation of protein aggregates, notably alpha-synuclein, b…
Posted May 21, 2026
Enhancing anti-tumor immunity in head and neck neoplasms
US National Cancer Institute · grant
Project 1: Optimize anti-tumor immunity with neoadjuvant immunotherapy for oral cavity cancers Background: Oral squamous cell carcinoma (OSCC), typically caused by carcinogen exposure, carries a poor prognosis. Roughly half of all patients …
Posted May 21, 2026
Regulation of IgE production during aeroallergen sensitization
US National Institute of Allergy and Infectious Diseases · grant
Project Summary/Abstract Asthma is a debilitating lung disease marked by reversible airway obstruction that affects over 5% of the US population and is growing in prevalence. In the majority of cases of asthma, allergic inflammation around …
Posted May 21, 2026
Mechanisms of GABAergic Signaling in the Suprachiasmatic Nucleus Network
US National Institute of Neurological Disorders and Stroke · grant
Project Summary/Abstract Hypothalamic suprachiasmatic nucleus (SCN) neurons express a cell-autonomous molecular clock that generates circadian rhythms and regulates physiological rhythms throughout the body. The molecular clock produces a c…
Posted May 21, 2026
PEDIATRIC ONCOLOGY CLINICAL RESEARCH TRAINING PROGRAM
US National Cancer Institute · grant
This proposal represents the renewal application of the Pediatric Oncology Clinical Research Training Program (POCRTP), developed by Texas Children’s Cancer Center (TCCC), which is jointly supported by Baylor College of Medicine’s (BCM) Dep…
Posted May 21, 2026
PaRtnEring to build understanding oF gEnomics Responsibly: the PREFER Community Health Worker Genomics Research Education Program
US National Human Genome Research Institute · grant
Recent trends highlight the importance of championing a genomics research workforce that is well-prepared to support genomics research. Offering training to the entry-level workforce such as Community Health Workers (CHWs) can support genom…
Posted May 21, 2026
Facilitating the Implementation of Population-wide Genomic Screening (FOCUS)
US National Human Genome Research Institute · grant
Population-wide genomic screening (PGS) for Hereditary Breast and Ovarian Cancer Syndrome, Lynch Syndrome, and Familial Hypercholesterolemia offers great promise in identifying the 1-2% of the population that unknowingly carries a pathogeni…
Posted May 21, 2026
Using a Superoxide Dismutase Mimetic to Mitigate Age-Associated, Radiation-Induced Cardiopulmonary Damage: Investigating the Role of Nitro-Oxidative Signaling and Mitochondrial Metabolism
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY/ABSTRACT. An aging population faces unique health challenges, including increased susceptibility to ionizing radiation (IR) toxicities due to oxidative and nitrative metabolic changes. Elderly individuals are particularly v…
Posted May 21, 2026
Linking in vivo hemodynamics with outcomes in Type B aortic dissection using 4D flow MRI
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY/ABSTRACT Type B aortic dissection (TBAD) risk-stratification is increasingly relevant in the era of thoracic endovascular aortic repair (TEVAR), as outcomes and costs can differ significantly depending on treatment choice an…
Posted May 21, 2026
Anatomic Imaging Derived 4D Hemodynamics using Deep Learning
US National Heart Lung and Blood Institute · grant
SUMMARY - ABSTRACT Thoracic aortic aneurysm is a highly prevalent disease which can lead to devastating complications including dissection or rupture. Early detection and regular monitoring of these patients via regular surveillance imaging…
Posted May 21, 2026
CE25-021 - Estimating the impact of alternative crisis response models on community violence
US · IL NIH RePORTER · grant
PROJECT SUMMARY/ABSTRACT Community violence (CV) is a pressing public health crisis in the United States (US), disproportionately affecting youth and young adults (YYA) ages 10-34. Racial and ethnic minority YYA experience a hugely dispropo…
Posted May 21, 2026
CE24-013 - Community-based evaluation of a novel, system-wide harm reduction strategic plan for people experiencing homelessness in New York City
US National Center for Injury Prevention and Control · grant
PROJECT SUMMARY/ABSTRACT Overdose (OD) and homelessness are two interlinked national crises in the United States (US). More than 1.25 million people experience homelessness each year, and drug OD is the leading cause of death among people e…
Posted May 21, 2026
A comparative evaluation of overdose prevention programs in New York City and Rhode Island
US National Institute on Drug Abuse · grant
More than one million people have died from accidental drug overdose in the United States (US) in the past 20 years. In response to this unabating crisis, New York City opened the first two publicly recognized overdose prevention centers (O…
Posted May 21, 2026
Investigating GLI transcription factors as regulators of the pancreatic cancer microenvironment
US National Cancer Institute · grant
PROJECT SUMMARY/ABSTRACT Pancreatic cancer is a deadly human malignancy, with a five-year survival rate of 11%. Further, the incidence of pancreatic cancer is rising and is projected to be the second-leading cause of cancer-related death in…
Posted May 21, 2026