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Showing 25 / 20086 · page 53/804
Design, prediction, and prioritization of systematic perturbations of the human genome
US National Human Genome Research Institute · grant
ABSTRACT Noncoding genetic variation that alters gene regulation is of paramount importance for health, disease, and evolution. Diseases ranging in incidence from the most common to the most rare all have substantial risk associated with re…
Posted May 21, 2026
NAFLD Diagnosis and Outcomes
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY Nonalcoholic fatty liver disease (NAFLD) affects 25-30% of US adults and has a major impact on healthcare burden and population health due to higher morbidity and mortality than the general population. Even though NAFLD can …
Posted May 21, 2026
Evaluating the Role of Social Connectedness in Recovery from Opioid Use Disorder during the Postpartum: A Supplement to Support Research Continuity
US National Institute on Drug Abuse · grant
ABSTRACT The current proposal requests an administrative supplement via NOT-OD-23-032 to support research continuity on NIH/NIDA R21DA058364 during a period of parental leave for the study MPI (Linde-Krieger). The goal of the parent study i…
Posted May 21, 2026
Research Training in Gastrointestinal and Hepatic Diseases
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY The accelerating pace of discovery in the basic biomedical, clinical and translational sciences now provides unprecedented opportunities to transform patient care in gastrointestinal and liver diseases. Over the past 35 year…
Posted May 21, 2026
Personalizing Therapies for Acute Kidney Injury in Cirrhosis
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY/ABSTRACT Acute kidney injury is a devastating complication of cirrhosis (Cirr-AKI). Current Cirr-AKI guidelines recommend all patients receive 1 g/kg/day of IV albumin for two days regardless of presenting features. However,…
Posted May 21, 2026
A 4D-tunable hydrogel for the study of the impact of the tumor microenvironment on the development of colorectal cancer
US National Cancer Institute · grant
Project Summary/Abstract The goal of this proposal is to develop a platform created from advanced biomaterials that enable novel investigations into the physiochemical roles of the tumor microenvironment (TME) on the origins of colorectal c…
Posted May 21, 2026
Development of an immunocompetent colon chip to model Crohn's Disease
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY/ABSTRACT The goal of this proposal is to develop an ex vivo experimental platform to enable novel investigations into the roles of the intestinal lumenal and basal microenvironment on the origins of Crohn's Disease (CD). CD …
Posted May 21, 2026
Design of an integrated microdevice to measure malignant lipid signaling in single cells from clinical samples
US National Cancer Institute · grant
PROJECT SUMMARY / ABSTRACT Engineering advances applied to miniaturized analytical instrumentation will be employed to improve sensitivity and throughput of thin-layer chromatography enabling single-cell analyses of the biochemical activity…
Posted May 21, 2026
Human Translational Bioinformatics Core
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY The overall objective of this SCORE is to elucidate sex differences in cardiometabolic disease and its risk factors and treatments using genetically modified mouse models, inbred mouse strains, and in vitro or cell-based ex…
Posted May 21, 2026
Genetic Predisposition to Myocardial Infarction in Patients with Coronary Artery Disease
US · IL NIH · grant
PROJECT SUMMARY Myocardial infarction (MI) and coronary artery disease (CAD) are the leading causes of death in Western societies. Individuals with CAD are typically asymptomatic, with the first manifestations often being major adverse car…
Posted May 21, 2026
Genetic and Gut Microbial Regulation of Indole-3 Propionate in Metabolic Disease
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY Metabolic diseases, such as obesity and type 2 diabetes (T2D), are characterized by perturbations of glucose tolerance, pancreatic beta cell function, energy imbalance, appetite regulation, and other unknown pathways. Clini…
Posted May 21, 2026
Modulation of network dynamics across mood states using closed-loop deep brain stimulation for depression
US National Institute of Mental Health · grant
Major Depressive Disorder (MDD) is a prevalent and debilitating disorder, where one-third of this population is treatment-resistant. Depression is characterized by cognitive dysfunction, including deficits in cognitive control, defined as f…
Posted May 21, 2026
Nuclear moonlighting of arsenic metabolic enzymes and reprogramming-resistant epimutations
US National Institute of Environmental Health Sciences · grant
PROJECT SUMMARY The overarching goal of the research presented in this application is to understand how environmental chemicals trigger a deregulation of the epigenome that can resist epigenetic reprogramming in germ cells and therefore ca…
Posted May 21, 2026
Role of epigenetic crosstalks in directing locus sensitivity to arsenic
US National Institute of Environmental Health Sciences · grant
PROJECT SUMMARY The overarching goal of the research presented in this application is to understand what make some genomic loci more susceptible than others to environmental chemical perturbation. Using inorganic arsenic (iAs) as a model e…
Posted May 21, 2026
Epigenetic and metabolic mechanisms of environmentally-induced transgenerational germline dysfunction
US National Institute on Alcohol Abuse and Alcoholism · grant
PROJECT SUMMARY The overarching goal of the research presented in this application is to dissect the genetic, epigenetic, and metabolic programs that encode and transmit a memory of environmental exposure for several generations. In that c…
Posted May 21, 2026
The Howard University Expanding Research in Alzheimer's Disease and Related Dementias Postbaccalaureate Research Education Program (HU-ERA-PREP)
US National Institute on Aging · grant
The Howard University-Enhancing Research in Alzheimer’s disease (HU-ERA) program is a two-year postbaccalaureate research training initiative designed to prepare recent college graduates for successful entry into advanced research careers i…
Posted May 21, 2026
Nanoreactor beads for POC TB resistance testing
US National Institute of Allergy and Infectious Diseases · grant
ABSTRACT Rapid and sensitive point of care tests that can detect all forms of drug resistance in tuberculosis (TB) are urgently needed to address the rise of drug resistance. We propose to develop a novel mutation detection system that use…
Posted May 21, 2026
Resources, Workforce Development, and Animal Models for the Rutgers RBL
US National Institute of Allergy and Infectious Diseases · grant
Overall ABSTRACT The Rutgers University Regional Biocontainment Laboratory (RBL) serves as a central facility to perform biosafety level three (BSL3) therapeutic, pathogenesis, and diagnostic research on high threat biological agents with …
Posted May 21, 2026
Point of care detection of fluroquinolone, bedaquiline and linezolid resistant Mycobacterium tuberculosis for rapid treatment decisions.
US National Institute of Allergy and Infectious Diseases · grant
ABSTRACT Rapid and sensitive point of care tests that can detect all forms of drug resistance are urgently needed to enable appropriate treatment for TB. Molecular drug susceptibility tests (mDSTs) which use nucleic acid amplification tech…
Posted May 21, 2026
Bacteria and Host in TB Transmission
US National Institute of Allergy and Infectious Diseases · grant
ABSTRACT Halting tuberculosis (TB) transmission will be most efficiently achieved by focusing control efforts on sites of high transmission and by developing new drugs and vaccines that target bacterial transmission. We hypothesize that ho…
Posted May 21, 2026
Unraveling the spectrum of intrabacterial amide hydrolysis to develop new classes of pyrazinoic acid prodrugs against pyrazinamide resistant Mycobacterium tuberculosis
US National Institute of Allergy and Infectious Diseases · grant
ABSTRACT Mycobacterium tuberculosis (Mtb) infection is a global health pandemic claiming 1.5 million lives each year. Current tuberculosis (TB) therapies are challenged by drug resistance, characterized by mutations that render approved dr…
Posted May 21, 2026
Lead Optimization and Preclinical Development of a small molecule inhibitor of M. avium KasA
US National Institute of Allergy and Infectious Diseases · grant
ABSTRACT. Non-tuberculous mycobacteria (NTM) constitute a major threat to global health with over 200,000 annual cases in the United States alone. Mycobacterium avium complex (MAC) infections are the most common cause of NTM pulmonary dise…
Posted May 21, 2026
Near patient detection of pathogenic candida species directly from blood and urine for rapid treatment response
US National Institute of Allergy and Infectious Diseases · grant
ABSTRACT Fungal species are among the most common causes of nosocomial bloodstream and invasive infections in immunocompromised hosts. Mortality from candidemia can be very high, ranging from 20-40%. The global emergence of virulent multid…
Posted May 21, 2026
Bacterial and Host Heterogeneity in TB latency, persistence and progression
US National Institute of Allergy and Infectious Diseases · grant
ABSTRACT - OVERALL Until recently, Tuberculosis (TB) has been viewed as a disease that progresses over several discrete stages, principally consisting of a period of infection followed by either active TB disease or a latent state with the …
Posted May 21, 2026
The development & pilot implementation of a Cas13a-based low-cost point-of-care assay for detecting Neisseria gonorrhoeae and molecular markers of antimicrobial resistance in resource-limited settings
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY Low-resource settings have a high burden of Neisseria gonorrhoeae infection, but insufficient laboratory infrastructure for diagnostic tests and antimicrobial susceptibility determination, leading to syndromic management, wh…
Posted May 21, 2026