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20,086 contracts

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Showing 25 / 20086 · page 54/804
RFA-DP-23-001, Simulation Model of Interventions Linking Evidence to SDOH (SMILES)
US · IL NIH RePORTER · NAICS 541715, 541511 · grant
PROJECT SUMMARY/ABSTRACT To support the Centers for Disease Control and Prevention (CDC) and states and communities in identifying programs, policies, or practices (PPP) that can reduce the ever-widening gaps in chronic disease incidence an…
Posted May 21, 2026
The Impact of Soluble ST2 on Lung Injury Onset and Resolution
US National Heart Lung and Blood Institute · grant
Project Summary Candidate: Jehan Alladina, MD is a physician-scientist at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS). Her post-doctoral research interrogated type 2 (T2) immune pathways in allergic asthma. Buildin…
Posted May 21, 2026
The Molecular and Cellular Basis of the Sleep Homeostat
US National Institute of Neurological Disorders and Stroke · grant
Project Summary Understanding why we sleep remains one of the most enduring mysteries in science. Nearly every organism examined, even jellyfish that lack a centralized nervous system, exhibits a restorative sleep-like state. While asleep, …
Posted May 21, 2026
Best Practices to Return Results About Pesticide Exposures in Family Child Care Homes
US National Institute of Environmental Health Sciences · grant
Abstract The goal of this study is to develop best practices for returning results to family child care home (FCCH) directors about pesticides present in their facilities. Best practices will be defined as activities that maximize comprehen…
Posted May 21, 2026
MUSICA - MUsic and Speech Induced Cerebral Activation
US National Institute of Neurological Disorders and Stroke · grant
Project Summary/Abstract Severe traumatic brain injury (TBI) has a high mortality, largely driven by the early withdrawal of life-sustaining therapies during hospitalization. This critical decision is influenced by whether patients remain u…
Posted May 21, 2026
Metabolomic interrogation of gut mechanosensing in Drosophila
US National Institute on Aging · grant
Project description Gut epithelium is the principal site in which neural, immune, microbial and dietary factors interact. These multi-system interactions critically regulate whole-body physiology including metabolism, immunity, and neurodeg…
Posted May 21, 2026
Soluble Epoxide Hydrolase Inhibitor GSK2256294 for Acute Ischemic Stroke
US National Institute of Neurological Disorders and Stroke · grant
Project Summary The proposed translational studies will determine the cereroprotective efficacy of GSK2256294, an FDA- approved soluble epoxide hydrolase (sEH) inhibitor. Inhibition of sEH increases the endogenous levels of its substrate ep…
Posted May 21, 2026
Role of GPR39 in Aging-Related Vascular Cognitive Impairment (VCI)
US National Institute on Aging · grant
Summary Abstract Vascular cognitive impairment (VCI) is the second most common cause of dementia after Alzheimer's disease. The most common cause of VCI is cerebral small vessel disease (SVD). The mechanisms underlying SVD are poorly unders…
Posted May 21, 2026
Training in Translational Science and Cardiovascular Research
US National Heart Lung and Blood Institute · grant
This proposal seeks support for a well-established training program in translational cardiovascular research for MD and PhD postdoctoral fellows at Oregon Health & Science University (OHSU). The training program has a long history of traini…
Posted May 21, 2026
Metabolic Syndrome Outcomes Among Patients with Tuberculosis in Tanzania
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY The prevalence of noncommunicable diseases such as diabetes and metabolic syndrome is increasing in settings where infectious diseases like tuberculosis (TB) are common. There is a clear bidirectional interaction between di…
Posted May 21, 2026
Promoting Lead Academic Participating Sites (LAPS) Studies Accrual and Lung cancer Screening in Oklahoma
US National Cancer Institute · grant
Abstract/Summary Lung cancer mortality in Oklahoma is higher than the national average with age adjusted rate of 46.5 compared to 35 per 100,000 population. I am a thoracic medical oncologist with high interest in clinical and translational…
Posted May 21, 2026
Clinical Protocol and Data Management
US National Cancer Institute · grant
CLINICAL PROTOCOL AND DATA MANAGEMENT: ABSTRACT The Clinical Protocol and Data Management (CPDM) function provides comprehensive management and support services for clinical research activities at the Stephenson Cancer Center (SCC). CPDM se…
Posted May 21, 2026
CRCNS: Emergence of Coordinated Multi-Region Brain Activity Supporting Behavior
US National Institute of Neurological Disorders and Stroke · grant
Changes in interactions between neurons enable diverse computations and flexible behaviors. Such changes can occur very rapidly by rerouting information flow through existing connections, or more slowly by updating connections. The propos…
Posted May 21, 2026
Neuroimaging and Connectome Analysis as a Diagnostic and Prognostic Biomarker of SCI Induced Neuropathic Pain
US National Institute of Neurological Disorders and Stroke · grant
The identification of prognostic and diagnostic biomarkers of spinal cord injury (SCI) and SCI induced pain will help to assign SCI patients to the correct treatment and rehabilitation regimes. Chronic neuropathic pain (NP) is a complicated…
Posted May 21, 2026
Circulating Genomic Determinants of Treatment Failure in Hodgkin Lymphoma
US National Cancer Institute · grant
PROJECT SUMMARY/ABSTRACT PIs: Ash Alizadeh, M.D./Ph.D. & Maximilian Diehn, M.D./Ph.D. Classical Hodgkin lymphoma (HL) is among the most curable human malignancies. However, strategies to personalize HL therapies and to minimize long-term at…
Posted May 21, 2026
A Contrast-free Ultrasound-based Quantitative Angio Flow Imaging Technique to Assess Peripheral Arterial Disease of Lower Limb
US National Heart Lung and Blood Institute · grant
Abstract/Summary PAD is characterized by impaired blood flow to the lower extremities, causing claudication and exercise intolerance. Up to now, assessment of PAD is mainly performed by determination of stenosis or occlusion in the large ar…
Posted May 21, 2026
Vanderbilt-Nigeria Research Ethics Training Program (V-NET)
US John E. Fogarty International Center for Advanced Study in the Health Sciences · grant
Project Summary Abstract To address the increasing demand for research in precision medicine in Africa, the proposed Vanderbilt- Nigeria Research Ethics Training Program (V-NET) is an innovative research ethics training program that involve…
Posted May 21, 2026
The Role of Tension Anisotropy in Fibroblast Activation
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Project Summary Fibroblasts play a crucial role in tissue function by generating and modulating contractile forces in response to environmental cues. Upon activation, they upregulate actin and myosin to enhance contractile force generation,…
Posted May 21, 2026
7T MRI as a potential tool for detection of pathology in Alzheimer's disease
US National Institute on Aging · grant
Project Summary/Abstract Amyloid-beta (Aβ) is a small piece of a larger protein called amyloid precursor protein. It accumulates in stages into microscopic amyloid plaques that are considered a hallmark of a brain affected by Alzheimer’s d…
Posted May 21, 2026
Proteomic and metabolomic trajectories of ARDS molecular phenotypes
US National Heart Lung and Blood Institute · grant
ABSTRACT. This application is for a K23 award for Narges Alipanah-Lechner, MD, MAS, a Clinical Instructor in the Division of Pulmonary/Critical Care Medicine at the University of California San Francisco. Dr. Alipanah- Lechner is a young in…
Posted May 21, 2026
Powassan virus evolution, fitness, and pathogenesis in the Northeast and Midwest United States
US National Institute of Allergy and Infectious Diseases · grant
Project Summary Tick-borne Powassan virus (POWV) is an emerging public health threat, but has been understudied to date. Since its discovery in 1958, human cases of POWV have been reported in the United States, Canada, and Russia. Starting …
Posted May 21, 2026
Shared Resource 09: Hematological Tissue Bank Shared Resource (HTBSR)
US National Cancer Institute · grant
PROJECT SUMMARY – HEMATOLOGY TISSUE BANK SHARED RESOURCE (HTBSR) The Ohio State University Comprehensive Cancer Center (OSUCCC) Hematology Tissue Bank Shared Resource (HTBSR) is a longstanding biobank, established in 1997, that procures, pr…
Posted May 21, 2026
Targeting c-Myc stability in c-Myc overexpressing large B-cell lymphoma
US National Cancer Institute · grant
Project Summary Double (DH) and triple-hit (TH) lymphomas (L) are rare high grade B-cell lymphomas with diffuse large B-cell (DLBCL) morphology characterized by the co-occurrence of chromosomal translocations involving MYC, BCL2, and/or BCL…
Posted May 21, 2026
Shared Resource 09: Leukemia Tissue Bank (LTBSR)
US National Cancer Institute · grant
PROJECT SUMMARY – LEUKEMIA TISSUE BANK SHARED RESOURCE (LTBSR) The LTBSR is a longstanding biobank, established in 1997, that procures, processes, and stores biologic material from consenting patients with hematologic diseases. The LTBSR pr…
Posted May 21, 2026
Regulation of epithelial barrier
US National Institute of Dental and Craniofacial Research · grant
Project summary Periodontitis and peri-implantitis are oral diseases characterized by loss of oral homeostasis and induction of inflammation. Although downstream inflammatory events that occur in connective tissue have been well recognized,…
Posted May 21, 2026