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Showing 25 / 20086 · page 8/804
Neuronal Circuit Controlling Sleep-Promoting Ventrolateral Preoptic Neurons
US National Institute of Neurological Disorders and Stroke · grant
Project Summary/Abstract Sleep is an active process requiring the participation of delimited nodes of sleep-promoting cell populations. Work over the last twenty years has demonstrated that galanin expressing neurons in the ventrolateral pr…
Posted May 21, 2026
Core C: Electrophysiology Core
US · IL NIH RePORTER · grant
Project Summary/Abstract The Electrophysiology Core (Core C) will provide services for in vitro electrophysiological studies using novel tools such as optogenetics and in vitro GCaMP6 calcium imaging. We will prepare brain slices, conduct p…
Posted May 21, 2026
Mechanisms of Translational Surveillance
US National Institute of General Medical Sciences · grant
Project Summary/Abstract A substantial fraction of human inherited disease-causing mutations introduce an early stop codon that truncates protein production and elicits mRNA decay in a process called Nonsense-Mediated mRNA Decay (NMD). Desp…
Posted May 21, 2026
Role of ATAD2 in Prostate Cancer Progression and Metastasis
US · IL NIH · grant
Prostate cancer remains the second-leading cause of cancer-related deaths in US men, mainly due to metastatic disease. Metastasis occurs most frequently in bones, thus entailing significant patient morbidity including pain, propensity to fr…
Posted May 21, 2026
Single-Cell Molecular Pathway Analysis in Aging Systems via Novel Mass Cytometry Methods
US · IL NIH · grant
Summary Different cell types, each with unique composition, properties, and functions, are essential to sustain life in an organism. Bulk analysis of such heterogeneous mixtures of cells does not distinguish the characteristics of a given c…
Posted May 21, 2026
Evaluating the role of the tumor macroenvironment in cancer cachexia
US National Cancer Institute · grant
Project Summary Cancer cachexia is a severe metabolic syndrome characterized by muscle and adipose wasting. It is a significant complication faced by cancer patients that reduces quality of life, limits treatment efficacy, and accounts for …
Posted May 21, 2026
Mentoring trainees from diverse backgrounds in community engaged research to promote cardiovascular health
US · CA · San Diego NIH · grant
Abstract: Dr. Arredondo is a professor of psychology at San Diego State University with an excellent track record of conducting NIH-funded patient-oriented research. The K24 will provide Dr. Arredondo with protected time to mentor trainees …
Posted May 21, 2026
Enhancing capacity in faith-based organizations to implement and sustain multilevel innovations to improve physical activity
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY Despite the benefits of physical activity (PA) to prevent cardiovascular disease (CVD) and other chronic diseases, few adult Latinas meet PA guidelines. Given the central role of faith-based organizations (FBOs) within the L…
Posted May 21, 2026
The Recruitment Core of SDSU HealthLINK Center for Transdisciplinary Health Disparities Research
US National Institute on Minority Health and Health Disparities · grant
RECRUITMENT CORE - Project Summary It is well recognized that scientific research has produced copious amounts of knowledge; however, a significant delay remains from scientific discoveries to the application of those discoveries. SDSU and …
Posted May 21, 2026
Conmigo: a multi-level mother-daughter physical activity intervention for pre-adolescent girls
US National Cancer Institute · grant
Fewer girls meet current physical activity (PA) guidelines, with lower rates observed among those from lower-income backgrounds and not socialized to engage in regular physical activity, contributing to widespread differences in health outc…
Posted May 21, 2026
Mechanisms of Thalamocortical Dysfunction and Social Deficits in FTD due to GRN Mutations
US · IL NIH · grant
Project Summary/Abstract Loss of function progranulin (GRN) mutations, most of which cause haploinsufficiency, are a major genetic cause of frontotemporal dementia (FTD) with TDP-43 pathology (FTD-TDP). Progranulin-boosting therapies are a …
Posted May 21, 2026
Treating colon cancer by regulating intestinal immunity through microbial metabolism
US · IL NIH · grant
PROJECT SUMMARY Colorectal cancer (CRC) is profoundly affected by the intestinal immune system and the intestinal microbiome, which can exert both pro- and anti-cancer effects that operate alongside cell-intrinsic mutational events. Immune …
Posted May 21, 2026
Engineered probiotic bacteria for colorectal cancer immunoprevention and interception
US National Cancer Institute · grant
PROJECT SUMMARY Synthetic biology is driving a new era of medicine through the genetic programming of living cells. One particular focus has been the engineering of bacteria as therapeutic delivery systems to selectively release therapeutic…
Posted May 21, 2026
Modulating the localization and persistence of microbial neoantigen vaccine vectors to enhance therapeutic efficacy
US National Cancer Institute · grant
PROJECT SUMMARY The development of neoantigen cancer vaccines is transforming cancer immunotherapy – providing an approach to stimulate pre-existing and de novo anti-tumor T cell responses. These vaccines are designed to introduce tumor-spe…
Posted May 21, 2026
Dynamic reprogramming of macrophage acetyl-CoA metabolism in endotoxin tolerance
US · IL NIH · grant
PROJECT SUMMARY / ABSTRACT Macrophages play a pivotal role in maintaining homeostasis by tightly regulating the inflammatory response. In response to endotoxins like lipopolysaccharide, they undergo dynamic reprogramming, transitioning from…
Posted May 21, 2026
A Novel RAD51-BRCA2 Complex Stabilizing Drug: A Medical Countermeasure for Mitigating Accidental Radiation Exposure
US · IL National Institutes of Health (NIH) · grant
Abstract Ionizing radiation (IR) exposure from accidents or warfare can cause severe damage to radiosensitive tissues, such as bone marrow, intestines, and blood vessels, leading to acute radiation syndrome (ARS) and delayed effects of acut…
Posted May 21, 2026
Phytotherapy for Endometriosis
US · IL NIH RePORTER · grant
ABSTRACT/SUMMARY Endometriosis is an inflammatory gynecological disease of reproductive-age women. The two major symptoms are chronic pelvic pain and infertility, which profoundly affect reproductive health and life quality. The pro- inflam…
Posted May 21, 2026
State of the Science Meeting Series: Health and Safety of Gulf Coast and U.S. Caribbean Fishers
US · IL National Institutes of Health (NIH) · grant
The objective of the proposed State of the Science Meeting Series: Health and Safety of Gulf Coast and U.S. Caribbean Fishers reflects an integrated, multi-disciplinary collaboration focused on evidence informed education bridging the gap b…
Posted May 21, 2026
Validation of blood-based predictive biomarkers of therapeutic response to neoadjuvant chemoradiation therapy in patients with locally advanced rectal cancer
US National Cancer Institute · grant
PROJECT SUMMARY/ABSTRACT Neoadjuvant chemoradiation therapy (nCRT) followed by surgery is the standard of care for patients with locally advanced rectal cancer (LARC), which accounts for ~60% of newly diagnosed rectal cancer cases. Althoug…
Posted May 21, 2026
New and Disruptive Therapeutic Approaches to Target Fundamental Molecular Mechanisms Underlying Atrial Fibrillation
US · IL NIH · grant
PROJECT SUMMARY Atrial fibrillation (AF) is the most common heart rhythm disorder that affects >3 million Americans and is a major cause of stroke. Since AF is primarily an age-related disease, it is fast becoming an epidemic in a rapidly a…
Posted May 21, 2026
Signaling mechanisms that modulate uterine 3D structure for pregnancy success
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY/ABSTRACT Although much is known about the embryo during early development, the structural uterine environment in which the early embryo develops is not well understood. A poor uterine environment at the time of blastocyst e…
Posted May 21, 2026
Chemistry-Biology Interface Predoctoral Training Program
US National Institute of General Medical Sciences · grant
Project Summary This proposal requests funds to support predoctoral trainees as part of the Chemical Biology Interface Training Program (CBITP) at New York University (NYU). Our program will catalyze interdisciplinary education at the inter…
Posted May 21, 2026
Biomolecular Recognition with Synthetic Protein Mimics
US · IL NIH · grant
Abstract Interactions of proteins with other biomolecules regulate fundamental cellular events and misregulation of these interactions leads to disease states. Proteins often utilize small folded domains for recognition of other biomolecule…
Posted May 21, 2026
The Effects of Neprilysin Inhibition on Cardiometabolic Health in Black Individuals
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY Black individuals have a higher prevalence of insulin resistance and are more likely to have cardiometabolic diseases, which is associated with an increased risk of mortality. The reasons for the increased insulin resistance…
Posted May 21, 2026
Natriuretic Peptide-Renin-Angiotensin-Aldosterone System Rhythm Axis and Nocturnal Blood Pressure
US · IL NIH · grant
PROJECT SUMMARY Non-dipping type of nocturnal blood pressure (BP) is common even among treated hypertensives and is associated with a nearly two-fold higher risk of adverse cardiovascular events. Obesity impacts nearly 40% of American adult…
Posted May 21, 2026