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20,086 contracts

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Showing 25 / 20086 · page 9/804
Mentored Patient-Oriented Research in Natriuretic Peptide System Based Precision Cardiometabolic Health
US · AL NIH · grant
PROJECT SUMMARY Dr. Pankaj Arora is an Associate Professor of Medicine (Tenured), the Director of the Cardiovascular Genomics Clinic, and the Director of the Clinical and Translational Research Program at the University of Alabama at Birmin…
Posted May 21, 2026
Atrial Natriuretic Peptide and Regulation of Cardiometabolic Health: A Genotype-Guided Human Physiological Study
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY The cardiometabolic disease burden is increasing in the United States. The atrial natriuretic peptide (ANP) hormone contributes to the regulation of glucose utilization, energy homeostasis and is a major determinant of cardi…
Posted May 21, 2026
Clinical Implementation of Blood Pressure Polygenic Risk Score: A Randomized Clinical Trial
US · IL NIH · grant
    Elevated blood pressure (BP) is the single greatest modifiable contributor to premature mortality globally. The development of hypertension (HTN) and associated adverse cardiovascular (CV) events is contributed by an interplay of geneti…
Posted May 21, 2026
Mount Sinai HHEAR Network Untargeted Lab Hub
US National Institute of Environmental Health Sciences · grant
PROJECT SUMMARY/ABSTRACT FOR OVERALL The Icahn School of Medicine at Mount Sinai will leverage our research expertise in environmental epidemiology, analytical chemistry and clinical practice to renew our Human Health Exposure Analysis Reso…
Posted May 21, 2026
Integrated Health Sciences Facility Core
US · IL Mount Sinai Center on Health and Environment Across the LifeSpan (HEALS) · NAICS 541715 · grant
Project Summary (IHSFC) The mission of the Mount Sinai Center on Health and Environment Across the LifeSpan (HEALS) is to promote team-based environmental health science (EHS) research that embraces the developmental origins of health an…
Posted May 21, 2026
Early Warning Systems for Childhood and Adult Disorders
US · IL NIH · grant
Project Summary According to the developmental origins of health and disease hypothesis, many disorders originate via environmental exposures in fetal and early postnatal life. Such early life environmental exposures can alter the developme…
Posted May 21, 2026
Organic-metal mixtures and neurodevelopment
US National Institute of Environmental Health Sciences · grant
Project Summary The study of chemical mixtures is a high priority as mixtures represent the real-life exposure scenarios that impact health. Mixtures are methodologically similar to studying the exposome (i.e. the study of all health releva…
Posted May 21, 2026
SARS-CoV-2 Virology Core
US · IL National Institute of Allergy and Infectious Diseases · grant
Viruses of the Coronaviridae family are enveloped viruses that possess a large (30kb), single-stranded, positive sense, RNA genome that infect a large number of mammals (alpha and beta coronaviruses) and birds (gamma coronaviruses). Four di…
Posted May 21, 2026
Rise-HP: Reimagining Interventions for Support and Education in Hypersensitivity Pneumonitis; A Stakeholder Engaged Intervention to Improve Health-Related Quality of Life
US National Heart Lung and Blood Institute · grant
Project Summary/Abstract Hypersensitivity Pneumonitis (HP) is an often incurable and potentially progressive fibrotic interstitial lung disease (ILD) with limited treatment options that leads to poor health-related quality of life (HRQOL). …
Posted May 21, 2026
Aryl hydrocarbon receptor and bilirubin as therapeutic target for ICH
US · IL NIH · grant
After intracerebral hemorrhage (ICH), phago(endo)cytosis of hematoma components [erythrocytes (RBC), hemoglobin (Hb) and heme], by microglia/macrophages (MMΦ) is essential for removal/detoxification of the hematoma, resolution of inflammati…
Posted May 21, 2026
Improving access to opioid use disorder treatment among marginalized patients with a tailored telehealth intervention
US National Institute on Drug Abuse · grant
PROJECT SUMMARY/ABSTRACT: The goal of this K23 award is to give the PI the skills and preliminary data needed to improve access to opioid use disorder (OUD) treatment with buprenorphine via telehealth care. Dr. Aronowitz is proposing a res…
Posted May 21, 2026
The contributions of interaurally correlated signals and interaurally symmetric place of stimulation for the binaural auditory system
US National Institute on Deafness and Other Communication Disorders · grant
PROJECT SUMMARY / ABSTRACT Binaural hearing provides substantial benefits in complex listening environments, improving the ability to understand speech and providing the ability to localize sounds. However, in order to take advantage of bin…
Posted May 21, 2026
Microbiota Metallophores: Probing Interactions and Nutrient Dynamics of the Human Gut
US · IL NIH · grant
Project Summary/Abstract A healthy human microbiome is intrinsically linked to vital physiological aspects such as development, immune function, and nutrition. The composition and function of the human microbiota is significantly influenced…
Posted May 21, 2026
Leukotriene B4 Regulation in Heart
US National Heart Lung and Blood Institute · grant
PROJECT ABSTRACT Patients with type 2 diabetes (T2DM) are at increased risk (~50%) relative to non-diabetic individuals of suffering sudden cardiac death (SCD), most often due to fatal ventricular arrhythmias such as torsades de pointes (T…
Posted May 21, 2026
Channelopathies of Inflammation
US · IL NIH · NAICS 541714 · grant
PROJECT ABSTRACT Obesity is associated with a higher risk for the development of malignant ventricular tachyarrhythmias (VT), particularly under conditions of repolarization disorders and QT interval prolonging mechanisms (an established ri…
Posted May 21, 2026
Pharmacokinetics of Long-Acting Preparations of Antitubercular Drugs in Rodents
US · IL NIAID Division of AIDS · grant
Preclinical Services for HIV Therapeutics: The purpose of these Indefinite Delivery/Indefinite Quantity contracts is to provide the extramural scientific community with research materials and preclinical product development support for cand…
Posted May 21, 2026
B. thuringiensis crystal proteins as powerful next-generation anthelmintics
US · IL NIH · grant
New treatments are urgently needed for parasitic gastrointestinal nematodes (GINs; hookworms, whipworms, roundworms) that infect ~1.5 billion people and cause significant morbidity in children, pregnant women, and working adults. Mass drug …
Posted May 21, 2026
Combining B. thuringiensis crystal proteins with small molecule anthelmintics to combat parasitic nematode resistance
US · IL NIH · grant
New treatments are urgently needed for parasitic gastrointestinal nematodes (GINs; hookworms, whipworms, roundworms) that infect ~1.5 billion people and cause significant morbidity in children, pregnant women, and working adults. The main d…
Posted May 21, 2026
Prefrontal impairment with stress- NE receptor subtype mechanisms.
US National Institute of Mental Health · grant
Abstract- The dorsolateral prefrontal cortex (dlPFC) mediates working memory and top-down control, but is impaired by acute or chronic stress, and is dysfunctional in most mental disorders. Stress exposure increases norepinephrine (NE) rele…
Posted May 21, 2026
Student Research Laboratory Core
US National Institute of General Medical Sciences · grant
Abstract: Student Research Laboratory Core Central to the development of any research center is the availability of research service cores to center investigators. Such cores can broaden investigators’ scope of research by supplying expert…
Posted May 21, 2026
Deciphering the role of heterochromatin in telomere function and maintenance mechanisms
US · IL NIH · grant
PROJECT SUMMARY Telomeres are nucleoprotein structures that protect the ends of linear chromosomes and thereby maintain genome stability. Telomeres solve both the end-protection and the end-replication problems: 1) They inhibit DNA damage a…
Posted May 21, 2026
Deciphering the function of the APE2 nuclease during repair by alternative end-joining and its role in HR-deficient cells
US · IL NIH · grant
PROJECT SUMMARY Homologous recombination (HR), a pathway that repairs DNA double strand breaks (DSB), is frequently mutated in cancers. HR-deficient cancers are prone to genomic instability and are critically dependent on other DNA repair …
Posted May 21, 2026
Improving HIV Prevention Through a Psychological Flexibility-Based Approach
US National Institute of Mental Health · grant
There continues to be a high incidence of HIV, particularly in the South. Thus, interventions to enhance engagement in prevention services are urgently needed. Engagement in pre-exposure prophylaxis (PrEP) care among people at risk of HIV l…
Posted May 21, 2026
Defective heme transport in the development of congenital hydrocephalus
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY/ABSTRACT Congenital hydrocephalus (CH) is a debilitating neurologic condition with complex genetic and environmental inputs, characterized by excessive accumulation of cerebro-spinal fluid (CSF) and enlarged ventricles. Emer…
Posted May 21, 2026
Structure-guiding tools to study the role of choline in the development of congenital hydrocephalus
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY The blood-brain barrier (BBB) is a term used to describe the unique properties of the blood vessels that vascularize the central nervous system (CNS) and restrict the movement of nutrients, ions and cells between the blood a…
Posted May 21, 2026