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Showing 25 / 20086 · page 136/804
Novel lead compound advancement for mitigating halogen-induced mortality and morbidity.
US National Institute of Environmental Health Sciences · grant
Summary: Chlorine and bromine (Cl2 and Br2) are highly reactive and extremely toxic halogen gases that cause debilitating cardiopulmonary injury and death. Research from our previously funded ‘Identification of Therapeutic Lead Compounds U0…
Posted May 21, 2026
A comprehensive valvular heart disease assessment with stress cardiac MRI
US National Heart Lung and Blood Institute · grant
Project Summary/Abstract Mitral valve regurgitation (MR) is a growing public health concern, and with an aging population, its prevalence is expected to rise steeply. For MR diagnosis and severity assessment, echocardiographic techniques ha…
Posted May 21, 2026
Combined inhibition of PLK1 and NOTCH for melanoma management
US Veterans Affairs · grant
The overall objective of this study is to determine the therapeutic efficacy of concomitant inhibition of PLK1 and NOTCH against melanoma progression and drug resistance as well as to identify novel signaling mechanisms associated with drug…
Posted May 21, 2026
Cancer Prevention and Control
US National Cancer Institute · grant
UWCCC Cancer Prevention and Control (CPC) Program Summary Co-Leaders: Lisa Cadmus-Bertram and Nihal Ahmad PROJECT SUMMARY/ABSTRACT The Cancer Prevention & Control (CPC) Program spans basic, clinical, and population science to identify effe…
Posted May 21, 2026
Functional and Therapeutic Significance of PLK4 in Melanoma
US National Cancer Institute · grant
SUMMARY: The objective of this study is to determine if the polo-like kinase 4 (PLK4) along with other melanoma driver pathways, is a therapeutically actionable druggable target for melanoma management, and what are the mechanisms and inte…
Posted May 21, 2026
Role of sirtuin 6 in melanoma development and progression
US Veterans Affairs · grant
Malignant melanoma is one of the deadliest forms of cancer among Veterans, and the existing therapeutic options have not been fully effective in melanoma management, primarily owing to acquired drug resistance. Therefore, novel target-based…
Posted May 21, 2026
Regulation of Oxytocin Receptor Signaling in Neurons
US National Institute of Mental Health · grant
PROJECT SUMMARY/ABSTRACT Social deficits are a prominent feature of autism spectrum disorder and many other neuropsychiatric diseases. Since there are currently no drugs available to treat these debilitating symptoms, it is critical to deci…
Posted May 21, 2026
Administrative Core
US National Institute of General Medical Sciences · grant
Project Summary/ Abstract The Center for Addiction and Disease Risk Exacerbation (CADRE) Administrative Core will provide the scientific leadership and administrative support necessary to ensure the success of this Phase II COBRE. Thus far…
Posted May 21, 2026
Implementation Science-Guided Pilot Study of Trauma-Focused Cognitive Behavioral Therapy for Autistic Youth in Community Mental Health Settings
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY The implications of trauma exposure on children’s development and proximal and future physical and mental health outcomes are well-established. Autistic youth are at an increased risk for trauma compared to non- autistic you…
Posted May 21, 2026
A Centralized Clinical Research Tool for Accelerating the Development, Evaluation, and Dissemination of Expert-Developed, Evidence-Based, and AI-Enhanced Digital Mental Health Therapies
US National Institute of Mental Health · grant
PROJECT SUMMARY/ABSTRACT Mental health burden in the US is substantial [1-3], with millions of people lacking access to effective and timely mental health care [4-6]. Although digital mental health technologies hold great promise for addres…
Posted May 21, 2026
Non-coding/epigenetic regulation
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
PROJECT 3 - SUMMARY Adolescent idiopathic scoliosis (AIS) affects ~3% of the population worldwide and is estimated to cost several billion dollars annually in surgeries alone in the US. The causes of AIS remain largely unknown. While mutati…
Posted May 21, 2026
EDGE CMT: Genomic characterization of mammalian adaptation to frugivory
US National Human Genome Research Institute · grant
PROJECT SUMMARY Overview: A comprehensive molecular understanding of how mammals ascertain complex traits to adapt to specific environments remains largely unknown. Here, we will take advantage of comparative and functional genomics to syst…
Posted May 21, 2026
Bioengineering adipocytes for cancer therapy
US National Cancer Institute · grant
PROJECT SUMMARY Increased glucose and fat metabolism are essential for tumor progression. Recent work showed that cold- induced activation of brown adipose tissue (BAT), a unique adipose tissue which produces heat via glycolysis and fat met…
Posted May 21, 2026
Role of skeletal muscle IPMK in nutrient metabolism and exercise
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
SUMMARY Inositol phosphates are critical signaling messengers involved in a wide range of biological pathways in which inositol polyphosphate multikinase (IPMK) functions as a rate limiting enzyme for inositol polyphosphate metabolism. Many…
Posted May 21, 2026
Respiratory Effects, Metal and Aldehyde exposure from e-cigarette use in young adults (REMA)
US National Institute of Environmental Health Sciences · grant
PROJECT SUMMARY My long-term goal is to become an independent investigator focusing on how pollutant exposures may adversely affect respiratory health and identify measures to effectively mitigate such exposures. My primary project objectiv…
Posted May 21, 2026
Using gene expression to identify patients at high risk for late breast cancer recurrence
US National Cancer Institute · grant
PROJECT SUMMARY Non-metastatic breast cancer is treated surgically and with adjuvant therapies. As these treatments have improved, recurrence-free survival has steadily increased, and late recurrence (recurrence beyond 10 years’ survival) h…
Posted May 21, 2026
Unraveling strain-level variation in the induction of anti-inflammatory responses in the intestine
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY: Inflammatory bowel disease (IBD) is an increasingly prevalent disease that currently affects ~1.3% of adults in the US. IBD is characterized by chronic inflammatory immune responses directed against the gut microbiota, and …
Posted May 21, 2026
Towards systematic analysis of cardiac voltage-gated sodium channel beta subunit function
US National Heart Lung and Blood Institute · grant
Abstract Voltage-gated sodium channels (NaVs) maintain the electrical cadence in cardiac muscle tissues by selectively controlling the rapid inward passage of sodium. The NaV complex is comprised of a 260-kDa pore- forming α-subunit (encod…
Posted May 21, 2026
A Versatile Chemical-Genetic Approach to Determine Bases for Arrhythmogenesis and Sodium Channelopathies
US National Heart Lung and Blood Institute · grant
Abstract The voltage-gated sodium channel NaV1.5 controls cardiac excitability and is an established therapeutic target. Mutations in the SCN5A gene, which encodes NaV1.5, are associated with inherited arrhythmia syndromes (long QT syndrome…
Posted May 21, 2026
Chemical biology of voltage-gated cation channels
US National Institute of General Medical Sciences · grant
Voltage-gated ion channels shape electrical signaling in the excitable cells of nerve and muscle. Sodium (NaV) and calcium channels (CaV) drive membrane depolarization and activate second messenger pathways via gated cellular entry of their…
Posted May 21, 2026
Closed-Loop Systems for Large Scale Spatiotemporal Imaging and Actuation of Neural Activity in Freely Behaving Animals
US National Institute of Neurological Disorders and Stroke · grant
ABSTRACT A major challenge in neuroscience is to uncover how defined neural circuits in the brain encode, store, modify, and retrieve information. Adding to this challenge is the fact that neural function does not operate in isolation but r…
Posted May 21, 2026
Advancing Infrastructure, Collaboration, and Innovation across the Open-Source UCLA Miniscope Ecosystem
US National Institute of Neurological Disorders and Stroke · grant
Project Summary The Open-Source UCLA Miniscope Project has become one of the most widely used open-source tools in neuroscience, democratizing access to innovative neural and behavioral imaging technologies. Over the past eight years of act…
Posted May 21, 2026
Cardiovascular Risk of Antiretroviral Therapy Drugs in HIV
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY Although antiretroviral therapy drugs (ART) have prevented HIV propagation and increased life expectancy of people with HIV (PWH), the rate of sudden death in this population is 2-4-times higher than people without HIV. Auto…
Posted May 21, 2026
Pilot Project 5 - Pancreatic Treatment
US National Cancer Institute · grant
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human malignancies and the survival rate remains stagnant with a 5-year survival rate of only 5-8%. Some populations in our catchment area have higher risk for PDAC and l…
Posted May 21, 2026
Adolescent & Young Adult SWG
US National Institute of Allergy and Infectious Diseases · grant
With an estimated 4 million adolescents and young adults (AYA) ages 10-24 years of age living with HIV and a steadily high proportion of new infections occurring among this age group, there is a critical need to focus on optimizing preventi…
Posted May 21, 2026