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20,086 contracts

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Showing 25 / 20086 · page 32/804
Understanding fertility trends in a cohesive high-fertility population within a low-fertility environment
US · IL NIH · NAICS 541720 · grant
Project Summary Western populations collectively responded to historically contingent, society-wide developments in the 19th and 20th centuries by reducing births to record-low levels. However, a minority of Westerners, largely ethnic secta…
Posted May 21, 2026
Development and testing of RSV vaccines using a computational framework of virus-host interaction
US · IL NIH · NAICS 541714 · grant
Respiratory Syncytial Virus (RSV) is the second leading cause of hospitalization in children worldwide and has been increasing appreciated as a cause of hospitalization and death in the elderly. Recent studies have shown that polyvalent vac…
Posted May 21, 2026
US Ten Day Seminar on the Epidemiology and Prevention of Cardiovascular Diseases and Stroke
US · IL National Heart, Lung, and Blood Institute (NHLBI) · grant
ABSTRACT This proposal requests sponsorship for the 49th U.S. Ten-Day Seminar. Given the burden of cardiovascular diseases (CVD) and stroke, it is highly appropriate to conduct professional training on epidemiology and prevention. The goals…
Posted May 21, 2026
Research and Mentoring in the Clinical Epidemiology and Health Disparities of Cardiovascular Diseases and Hypertension
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY Cardiovascular disease affects nearly half of all American adults. Achieving cardiovascular health is associated with lower mortality and morbidity, but modifying and adhering to health behaviors such as diet and other healt…
Posted May 21, 2026
The effects of synaptically released zinc on neuronal processing and brain function
US · IL NIH · grant
Project Abstract Many regions of the brain including the cortex, hippocampus, basal ganglia, and limbic structures are highly enriched with synaptic zinc. Synaptic zinc (as Zn2+) is loaded into presynaptic vesicles by zinc transporter 3 (Zn…
Posted May 21, 2026
Linking State Medicaid and Congenital Heart Surgical Registry Data: Building Capacity to Assess Disparities in Longitudinal Outcomes and Value for Children with Congenital Heart Disease
US National Heart Lung and Blood Institute · grant
Congenital heart defects are the most common birth defects managed in the United States, affecting 1% of live births. Survivors often describe significant, chronic disease. Yet, limited longitudinal data exist. Further, income and other dem…
Posted May 21, 2026
CLINICAL TRIALS MONITORING SERVICE
US · IL National Cancer Institute (NCI) · grant
This is a Research and Development Support contract. The purpose of this acquisition is to assist the NCI in fulfilling its responsibilities to the Food and Drug Administration (FDA) and Department of Health and Human Services (DHHS) regul…
Posted May 21, 2026
CLINICAL TRIALS MONITORING SERVICE_ Moonshot support
US · IL National Cancer Institute (NCI), National Institutes of Health (NIH) · NAICS 541715 · grant
This is a Research and Development Support contract. The purpose of this acquisition is to assist the NCI in fulfilling its responsibilities to the Food and Drug Administration (FDA) and Department of Health and Human Services (DHHS) regula…
Posted May 21, 2026
Mechanisms of Neoplastic Hybrid Cell Dissemination in Colorectal Cancer
US · IL NIH · grant
Project Summary Metastatic disease is the primary cause of cancer morbidity and mortality, resulting in >10 million deaths worldwide in 2020. Despite recent advances in our knowledge of metastatic tumor development, there is a critical nee…
Posted May 21, 2026
Cultural Pride Reinforcement for Early School Readiness: Pilot Randomized Controlled Trial of a Clinic-Based Intervention for Young African American Children
US · CA · Los Angeles National Institutes of Health (NIH) · grant
This career development award will establish Dr. Ashaunta Anderson, MD, MPH, MSHS, as an independent investigator with a focus on the development, implementation, and dissemination of evidence-based interventions for young African American …
Posted May 21, 2026
Self-Concept Reinforcement for Early School Readiness: Pilot Randomized Controlled Trial of a Clinic-Based Intervention for Young African American Children
US National Institute on Minority Health and Health Disparities · grant
This career development award will establish Dr. Ashaunta Anderson, MD, MPH, MSHS, as an independent investigator with a focus on the development, implementation, and dissemination of evidence-based interventions for young African American …
Posted May 21, 2026
Quantitative magnetic resonance imaging in patients with femoroacetabular impingement syndrome
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
PROJECT SUMMARY Femoroacetabular impingement syndrome (FAIS) is a common cause of hip pain and disability and a known risk factor for hip osteoarthritis (OA). Patients with FAIS present with a loss of sphericity of the femoral head, reduct…
Posted May 21, 2026
Morphologic and Kinematic Adaptations of the Subtalar Joint after Ankle Fusion Surgery in Patients with Varus-type Ankle Osteoarthritis
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
PROJECT SUMMARY Tibiotalar arthrodesis, or ‘ankle fusion’, is the gold standard surgical treatment for posttraumatic ankle osteoarthritis (OA). Ankle fusion brings pain relief, at least in the short term; however, elimination of motion at t…
Posted May 21, 2026
Morphological and Biomechanical Insights into the Pathophysiology of Femoroacetabular Impingement Syndrome
US · IL NIH · NAICS 541715 · grant
PROJECT SUMMARY By some estimates, femoroacetabular impingement syndrome (FAIS) accounts for 82% of hip osteoarthritis (OA) cases. FAIS patients present with a loss of sphericity of the femoral head, reduction in femoral-neck offset, and/o…
Posted May 21, 2026
Role of metabolic crosstalk in determining immunity during tumor progression
US · IL NIH · grant
PROJECT SUMMARY Tumor cells and infiltrating immune cells co-evolve during the course of tumor progression, with the immune system progressively losing its efficacy as tumors advance. Immune cells are highly dependent on cellular metabolism…
Posted May 21, 2026
A TCF1:Glucocorticoid regulatory circuit controls IL-23-driven Th17 pathogenicity
US · IL NIH · grant
PROJECT SUMMARY CD4+ IL-17-producing T helper cells (Th17) are known drivers of central nervous system (CNS) autoimmune inflammation in multiple sclerosis (MS), yet not all Th17 cells drive disease. Indeed, two major Th17 subtypes have been…
Posted May 21, 2026
Regulation of stem-like CD8+ T cells and their role in immunotherapy
US · IL NIH · grant
PROJECT SUMMARY Immune checkpoint receptors (e.g. CTLA-4, PD-1, Tim-3) are expressed on dysfunctional or “exhausted” CD8+ tumor-infiltrating lymphocytes (TILs) that exhibit defective effector functions (cytotoxicity and pro-inflammatory cyt…
Posted May 21, 2026
UAB National Coordinating Center for the George M. O'Brien Kidney National Resource Centers
US · AL · Birmingham National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · grant
For over 30 years, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) has funded the O’Brien Kidney Center program to advance kidney-related research. To expand the breadth and impact of these centers, NIDDK has mo…
Posted May 21, 2026
Project 1: Delta immune Ecology of NSCLC
US National Cancer Institute · grant
Summary – Project 1 Project 1 will study the ∆-Ecology of tumor-immune interactions in NSCLC, with a focus on KRAS-mutant cancers. Immunotherapy has demonstrated response rates of 30 to 45%. Most responses are followed by evolution of resis…
Posted May 21, 2026
The Delta Ecology of NSCLC Treatment
US National Cancer Institute · grant
Summary – Moffitt CSBC Proposal Overview The Moffitt CSBC proposal is focused on the essential and highly dynamical interplay between cancer cell evolution and the constantly changing ecology of the lung microenvironment. Tumors are not si…
Posted May 21, 2026
Investigating the role of CD44 and immune-neuro signaling mechanisms in neural stem cell responses after spinal cord injury
US National Institute of Neurological Disorders and Stroke · grant
Project Summary Spinal cord injury (SCI) results in long-term functional impairments due to loss of cord tissue and limited regeneration. Human neural stem cell (hNSC) transplantation has exciting potential as a treatment for SCI, but the c…
Posted May 21, 2026
Improving the sensitivity and specificity of diffusion MRI
US · IL NIH · NAICS 541715 · grant
PROJECT SUMMARY/ABSTRACT The ability to detect fiber pathways and assess tissue microstructure in vivo has opened a new window on the brain, with important applications ranging from brain connectomics to stroke detection and surgical planni…
Posted May 21, 2026
Control of reproductive aging by germline stem cells
US · IL NIH · grant
Project Summary/Abstract Adult stem cell exhaustion is a hallmark of aging. However, mechanisms of stem cell exhaustion during aging are largely unknown, and there are no therapies that can delay stem cell aging in humans. C. elegans is a p…
Posted May 21, 2026
Flow Cytometry Workshops in Africa
US · IL NIH RePORTER · grant
Project Summary Flow cytometry is a specialized technology that characterizes cells on a single-cell basis and is heavily used in the fields of immunology, infectious diseases and cancer biology. As flow cytometry technology has advanced, t…
Posted May 21, 2026
Phenotyping and Biospecimen Core
US National Institute on Aging · grant
The Phenotyping and Biospecimen (P&B) Core's primary mission is to leverage two NIA-funded centenarian studies by sifting through their study participants in identifying centenarian cognitive superagers, offspring and offspring spouses for …
Posted May 21, 2026