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Showing 25 / 20086 · page 64/804
Developing robust and scalable genomics tools and databases to analyze immune receptor repertoires across broad populations
US National Institute of Allergy and Infectious Diseases · grant
Abstract The recent advances in high-throughput sequencing technologies enable cost-effective characterization of the immune system and provide novel opportunities to study adaptive immune receptor repertoire (AIRR) at the population scale.…
Posted May 21, 2026
Leveraging the TCR Repertoire to identify target neoantigens in FLT3-ITD positive Acute Myeloid Leukemia
US National Cancer Institute · grant
Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for patients with high- risk acute myeloid leukemia (AML). However, HSCT is affected by graft-versus-host disease (GvHD) and graft- versus-leu…
Posted May 21, 2026
Social Processes Underlying Co-Occurring ADHD and Anxiety Across the Lifespan
US National Institute of Mental Health · grant
ABSTRACT/PROJECT SUMMARY Anxiety is one of the most common and debilitating comorbidities with ADHD, affecting 57% of youth and 84% of adults, with particularly high rates in girls and women. Despite its widespread prevalence, this co-occur…
Posted May 21, 2026
Optimizing PepTAC structure and amphiphilicity for enhanced target protein degradation
US National Institute of General Medical Sciences · grant
Project Summary This study seeks to advance heterobifunctional degraders that induce targeted protein degradation through the ubiquitin proteasome pathway. Typically, molecular degraders involve a ligand that recruits an E3 ubiquitin ligase…
Posted May 21, 2026
Development of Targeted Antipseudomonal Bactericidal Prodrugs
US National Institute of Allergy and Infectious Diseases · grant
Bloodstream infections (BSI) caused by Pseudomonas aeruginosa have a high fatality rate. They often arise in patients suffering from pneumonia, urinary tract infections, surgical site infections, or patients with severe underlying condition…
Posted May 21, 2026
A Model Editing Framework for Participatory Multimodal AI in Dermatology
US NIH Office of the Director · grant
Abstract (250 Words) Multimodal artificial intelligence (MAI) systems hold significant promise for improving diagnostic accuracy in diverse clinical domains, particularly in dermatology, where various data sources such as clinical images, d…
Posted May 21, 2026
Electrocardiographic Detection of Non-ST Elevation Myocardial Events for Accelerated Classification of Chest Pain Encounters (ECG-SMART 2)
US National Heart Lung and Blood Institute · grant
Electrocardiographic Detection of Non-ST Elevation Myocardial Events for Accelerated Classification of Chest Pain Encounters (ECG-SMART-2) ABSTRACT There is a clear need to develop improved tools to stratify risk in patients who seek emerg…
Posted May 21, 2026
Mutation-independent therapy for retinal degenerations caused by PRPH2 mutations
US National Eye Institute · grant
Summary Expression of pathogenic variants in Peripherin-2 (PRPH2) leads to various forms of retinal dystrophies, with the mechanisms of degeneration remaining poorly understood. However, studies in mouse models expressing equivalent mutatio…
Posted May 21, 2026
Toward Targeting GPR31 and GPR39 Signaling in Diabetic Retinopathy
US National Eye Institute · grant
Summary G-coupled protein receptor-31 and 39 (GPR31/GPR39) are specific receptors for 12/15-Lipoxygenase (12/15- LO) metabolites; 12- and 15-HETEs respectively. The role of GPR31/GPR39 in the pathogenesis of diabetic retinopathy (DR) has no…
Posted May 21, 2026
Antiangiogenic Therapy to Reduce Bleeding and Improve Health-Related Quality of Life in Hereditary Hemorrhagic Telangiectasia
US National Heart Lung and Blood Institute · grant
Project Summary/Abstract Hereditary hemorrhagic telangiectasia (HHT), an autosomal dominant bleeding disorder affecting 1 in 5000 people in the US, is a devastating lifelong condition with no FDA-approved treatments. Accordingly, there is a…
Posted May 21, 2026
Characterizing Sleep Health, Sleep Disorders, and Cognitive Functioning After Heart Transplantation
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY/ABSTRACT Cognitive impairment impacts 30-63% of the people who receive a heart transplant. Cognitive impairment limits their ability to self-manage the necessary and complex medical regimens required to maintain viability of…
Posted May 21, 2026
Tracking how molecular machines propagate epigenetic information in time and space
US National Institute of General Medical Sciences · grant
ABSTRACT Heterochromatin, a gene-repressive nuclear ultrastructure, is required for the normal patterning of the genome into active and inactive regions, to preserve structural integrity and drive and maintain developmental fates. While het…
Posted May 21, 2026
Biochemically counteracting maladaptive functions of G9a/GLP in addiction
US National Institute on Drug Abuse · grant
ABSTRACT The development of addictive behaviors to stimulants and opiates requires changes in the reward center of the brain, in particular, the Nucleus Accumbens. Animal studies and examination of postmortem human cocaine users have indica…
Posted May 21, 2026
Blood Pressure Control Advancing Refugee Health Equity (BPCARE): an RCT of adherence
US National Heart Lung and Blood Institute · grant
Project Summary A persistent ~50% of Americans with hypertension are non-adherent to antihypertensive medications. These rates are even lower for refugees, whose numbers are at an all-time high. Uncontrolled blood pressure is the leading ca…
Posted May 21, 2026
Community Liaison and Recruitment Core
US National Institute on Aging · grant
ABSTRACT The Community Liaison and Recruitment Core (CLRC) will work together with the other cores of the San Diego Alzheimer’s Disease Resource Center for Minority Aging Research (SD AD-RCMAR) to train Scientists to understand and employ a…
Posted May 21, 2026
The Serine Protease HTRA1 Antigen: A Gateway to Elucidating Membranous Nephropathy Pathogenesis and the Targeting of Antigen Epitopes
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Abstract Primary membranous nephropathy (MN) is a major cause of nephrotic syndrome and kidney diseases. This autoimmune condition is characterized by the accumulation of immune complexes along the glomerular basement membrane (GBM). What …
Posted May 21, 2026
Unraveling the systemic manifestations of pulmonary arterial hypertension on lean muscle mass
US National Heart Lung and Blood Institute · grant
Project Summary While pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature associated with high morbidity and mortality, it also has multiple systemic manifestations affecting many organs. There is a …
Posted May 21, 2026
RACE-CARS DCC 2/2
US National Heart Lung and Blood Institute · grant
Project Abstract Approximately 350,000 people suffer out-of-hospital cardiac arrest (OHCA) each year, with an average survival rate with good neurological function of only 9.0%. In response to the clear public health imperative signaled by …
Posted May 21, 2026
Enzyme-Mediated Depletion of Extracellular Adenosine and 5'methylthioadenosine as a Novel Anti-Cancer Therapeutic
US National Cancer Institute · grant
PROJECT SUMMARY In recent years, adenosine has been identified as an important therapeutic target due to its observed immunosuppressive effects in the tumor microenvironment. By agonism to adenosine receptors, adenosine is a broad suppresso…
Posted May 21, 2026
Inhibitors of Human Factor XIIIa as New Anticoagulants
US National Institute of General Medical Sciences · grant
SUMMARY The long-term goal of our research is to develop effective anticoagulants that do not cause bleeding complications to be safely used for a wider range of patients suffering from venous thromboembolism (VTE). This project aims at dev…
Posted May 21, 2026
Defining Tumor Microenvironmental Interactions that drive THY1-Mediated Treatment Resistance in Glioblastoma
US National Institute of Neurological Disorders and Stroke · grant
This K08 proposal will complete Dr. Wajd Al-Holou’s training towards his long-term career goal of directing an independent research program that aims to define critical cellular interactions in the tumor microenvironment that drive treatmen…
Posted May 21, 2026
Targeting of Doppel-axis to Control Lung Tumor Angiogenesis and Immunity
US National Cancer Institute · grant
Project summary Tumors, just like normal tissues, require blood vessels to receive nutrients and oxygen and to eliminate wastes and carbon dioxide. To ensure this blood supply, tumors create their own vascular beds from established blood ve…
Posted May 21, 2026
The role of Fusobacterium nucleatum and Candida albicans interkingdom interactions in promoting OSCC
US National Institute of Dental and Craniofacial Research · grant
PROJECT SUMMARY Oral squamous cell carcinoma (OSCC) exerts a significant clinical and financial burden worldwide. Recently, there has been increasing interest in the role of the microbiome in OSCC. Among microbial species that have frequent…
Posted May 21, 2026
Development and application of a quantitive model for HIV-1 transcriptional activation driven by TAR RNA conformational dynamics
US National Institute of Allergy and Infectious Diseases · grant
Project Summary Many processes essential for HIV-1 viral replication are driven by the association of regulatory RNA elements in the retroviral genome and host/viral proteins that form biologically active complexes. Despite advances in solv…
Posted May 21, 2026
Role of DNA structural dynamics in mutagenesis and oncogenesis
US National Institute of General Medical Sciences · grant
Project Summary Mutations are fundamental to evolution, yet they can also cause cancer and various genetic disorders. Despite their significance, our understanding of processes which generate or defend against mutations is incomplete. We do…
Posted May 21, 2026