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Showing 25 / 20086 · page 66/804
Cellular Senescence in Trisomy 21 lung disease
US National Heart Lung and Blood Institute · grant
SUMMARY Trisomy 21 (T21) occurs in ~1 in 700 live births resulting in Down Syndrome (DS), where pulmonary complications are the main cause of hospitalizations in children and adults. These include tracheobronchial diseases presenting as dec…
Posted May 21, 2026
Cancer Research Training and Education Coordination
US National Cancer Institute · grant
CANCER RESEARCH TRAINING AND EDUCATION COORDINATION (CRTEC) – ABSTRACT Karmanos Cancer Institute (KCI) provides extensive cancer research training and educational programs that span all career stages. Dr. Michele Cote (PSDR), Associate Cen…
Posted May 21, 2026
NextGen Oncology Scholars: Nurturing Tomorrow's Pioneers
US National Cancer Institute · grant
In an era where new discoveries in cancer biology can reveal profound insights into disease progression, prevention, and treatment, it is imperative to cultivate the next-generation cadre of researchers, equipped with hands-on experience an…
Posted May 21, 2026
Trypanosome Transmission Biology in Tsetse
US National Institute of Allergy and Infectious Diseases · grant
This application is on Human African Trypanosomiases (HAT), one of the most neglected diseases of sub- Saharan Africa. Despite the anticipated elimination of the gambiense disease by 2030, control in conflict-ridden and remote areas where H…
Posted May 21, 2026
Role of interneurons in brain tissue oxygen regulation
US National Institute of Neurological Disorders and Stroke · grant
The regulation of oxygen in brain tissue is a fundamental question in neuroscience and medicine, as it is crucial for maintaining optimal brain function. GABAergic interneurons, which provide inhibitory signals in the cerebral cortex, have …
Posted May 21, 2026
Circuit Mechanisms Underlying Persistent Activity in a Neural Integrator
US National Eye Institute · grant
Abstract Short-term memory function is commonly supported through persistent activity, the sustained response of populations of neurons following the offset of a memorized stimulus. This form of activity underlies diverse tasks including na…
Posted May 21, 2026
Comprehensive functional phenotyping of trigeminal neurons innervating temporomandibular joint (TMJ) tissues in male female and aged mice primates and humans with and without TMJ disorders (TMJD)
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
The knowledge of the function, types, distributions, and plasticity of afferent neurites innervating temporomandibular joint (TMJ) tissues is needed to understand the underlying mechanisms controlling the development of temporomandibular jo…
Posted May 21, 2026
The Black Zones: Harnessing Tech Enabled Community Driven Data, Big Population Health Data, & Agent-Based Models to Transform the Measures & Metrics around Longevity
US · IL NIH · grant
Abstract Shorter Black life expectancy of African Americans (AAs) and Black Immigrants (BI) in the U.S. is well documented and has been linked to a variety of factors such as food deserts, pollution, low socioeconomic position, and resource…
Posted May 21, 2026
Sodium Glucose Cotransporter-2 Inhibitors for the Amelioration of Acute Cardio-Renal Syndrome
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY | Candidate: The candidate is an Instructor of Medicine (Nephrology) with 3 years of ongoing training in clinical research in acute kidney injury (AKI) and clinical trial design and conduct under the mentorship of the direct…
Posted May 21, 2026
SIV zoonosis using humanized mice
US National Institute of Allergy and Infectious Diseases · grant
Project Summary/Abstract: The main goal of our proposed studies is to evaluate select SIVs for their potential for human transmission using a humanized mouse (hu-mouse) human surrogate animal model. Cross-species transmission events give ri…
Posted May 21, 2026
Label-free optical imaging for human mesoscale connectivity with a focus on deep brain stimulation targets
US National Institute of Mental Health · grant
PROJECT SUMMARY AND ABSTRACT Many neurological and psychiatric disorders are essentially connectionist disorders: certain sets of neurons have abnormally increased or decreased connectivity with other sets of neurons. Deep brain stimulation…
Posted May 21, 2026
The metabolic clock as a regulator of cell fate decision
US National Institute of General Medical Sciences · grant
Project Summary: Our organs respond dynamically to changes in the body’s demands by adapting both their size and activity levels. In these processes, mechanisms governing cell fate decisions, which influence the equilibrium between cell dea…
Posted May 21, 2026
Deciphering the specificity and molecular mechanisms of regulatory T cells using novel approaches
US National Institute of Allergy and Infectious Diseases · grant
Project Summary: Autoimmunity is a leading cause of chronic illness that encompasses more than 80 individual diseases. Due to the rising prevalence of these diseases, autoimmunity associated health problems currently affect over 20 million …
Posted May 21, 2026
GABAA receptors: function, physiology and involvement in anesthesia
US National Institute of General Medical Sciences · grant
ABSTRACT The γ-aminobutyric acid type A (GABAA) receptor is an ionotropic inhibitory ion channel. Inhibition mediated by GABAA receptors sets the level of activity in the brain, whereas in individual cells it determines the propensity of a …
Posted May 21, 2026
The role of EZH1 in neuronal differentiation and neurological disorders
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY Intellectual disabilities (ID) are lifelong conditions caused by neurodevelopmental errors. We recently identified gain and loss of function (GOF and LOF) mutations in the chromatin modifier Enhancer of Zeste Homologue 1 (EZ…
Posted May 21, 2026
Unraveling the Role of Langerhans Cells in Itch
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
PROJECT SUMMARY Chronic itch is a considerable medical challenge associated with various skin and systemic diseases, , exerting a profound impact on patients' overall quality of life. While the epidermis is conventionally considered the so…
Posted May 21, 2026
Interplay Between Langerhans Cells and Sensory Neurons: Impact on Wound Healing and Nociception Following Burn Injuries
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY Effective wound care is of paramount importance for individuals who have sustained burn injuries. Wound healing is intricately associated with the sensations of itching and pain, which can significantly impact a patient's q…
Posted May 21, 2026
A Decentralized, Status neutral, Stakeholder-engaged, post-incarceration intervention for people with and at risk for HIV
US · IL NIH · grant
A. Abstract One out of six people with HIV (PWH) in the U.S. are incarcerated annually; two-thirds of incarcerated persons meet criteria for substance use disorder (SUD) and many more in carceral settings are at risk for HIV. Ending the U.…
Posted May 21, 2026
Leveraging community health workers to improve SARS-CoV-2 testing and mitigation among criminal justice-involved individuals accessing a corrections-focused community-based organization
US · IL · New York City NIH · grant
Abstract. The United States (U.S.) has experienced higher mortality than any other nation due to COVID-19 with nearly 13.5 million cases and over 268,103 deaths. Due to the limited ability to socially distance, poor ventilation, and limite…
Posted May 21, 2026
RNA modification and innate immune activation in HIV infection
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY People living with HIV (PLWH) on anti-retroviral therapy (ART) still suffer from HIV-associated non-AIDS complication (HANA) such as neurocognitive disorders. Although chronic inflammation has been thought to be the driver o…
Posted May 21, 2026
Chronic Social Stressors and Biological Embodiment of Risk in Breast Cancer Mortality
US National Cancer Institute · grant
Breast cancer mortality differs significantly by several demographic factors, including socio-economic status, access to care, geographic residence and race/ethnicity. Despite extensive investigation, the known causes to date do not adequat…
Posted May 21, 2026
A Role of Multilevel Healthcare Access Dimensions in Ovarian Cancer Disparities
US National Cancer Institute · grant
Ovarian cancer accounts for more deaths than any other cancer of the female reproductive system. In 2021, there were 21,410 new cases of OC and 13,770 deaths. Remarkable progress has been made in ovarian cancer treatment, resulting in a 33%…
Posted May 21, 2026
Cerebral Small Vessel Disease and Brain Health in an Indigenous African Cohort (cSVD-IAC)
US National Institute on Aging · grant
cSVD-IAC: Project Summary The overarching goal of cSVD- IAC is to characterize the burden of cerebral small vessel disease (SVD) [white matter hyperintensities (WMH), lacunar infarcts, enlarged perivascular spaces, microbleeds, cerebral atr…
Posted May 21, 2026
Biological Indicators of Racial Disparity in Ameloblastoma Recurrence
US National Cancer Institute · grant
Project Summary Ameloblastoma accounts for 14% of all odontogenic tumors and African-Americans are five times more likely to develop ameloblastoma compared to Caucasians. Despite radical surgery, 10% of ameloblastomas recur and 25% of recur…
Posted May 21, 2026
Delaware Clinical and Translational Research ACCEL Program (Professional Development Core)
US National Institute of General Medical Sciences · grant
ABSTRACT – PROFESSIONAL DEVELOPMENT CORE Primary goals of the Delaware CTR ACCEL program include facilitating clinical and translational research (CTR) across disciplines and increasing faculty competitiveness for research funding. The ACC…
Posted May 21, 2026