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Showing 25 / 20086 · page 129/804
An Artificial Intelligence Foundation Model for Functional Neuroimaging: Personalized Prediction, Treatment Stratification, and Biotype Discovery in Major Depressive Disorder
US National Institute of Mental Health · grant
PROJECT SUMMARY Major depressive disorder (MDD) is a leading cause of disability, with substantial individual and societal costs. The heterogeneity of MDD and the lack of predictive tools for individualized treatment present significant chal…
Posted May 21, 2026
Protein tyrosine phosphatase non-receptor 14 in vascular stability and remodeling
US National Heart Lung and Blood Institute · grant
ABSTRACT The vascular system is critical to life, infusing each organ of the body with oxygen and nutrients, and transporting and interacting with immune cells that protect the body. In the adult, maintenance of an intact vascular endotheli…
Posted May 21, 2026
A network approach to interrogate cellular plasticity and drug resistance in cancer
US National Cancer Institute · grant
ABSTRACT We will address a critical problem in clinical oncology, namely how highly heterogeneous, drug resistant tumor cell populations develop, and how they can be targeted. Most tumors develop resistance to almost every type of therapy, …
Posted May 21, 2026
The contribution of HSV-2 ICP34.5 variation to neurovirulence during neonatal infection
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY / ABSTRACT Herpes simplex virus (HSV)-2 infection of the neonatal brain causes severe meningoencephalitis and permanent neurologic deficits. However, infants infected with HSV-2 at the time of birth follow different clinica…
Posted May 21, 2026
Design of a Novel Nanocarrier Technology to Drug-Load CAR T cells
US National Cancer Institute · grant
Project summary: Current treatment for Glioblastoma Multiforme (GBM), the most common malignant brain tumor in adults, involves maximal safe resection, followed by adjuvant chemoradiation. Although this treatment is life prolonging, it is n…
Posted May 21, 2026
A non-canonical role of Caspase-1 in regulating bacterial antimicrobial resistance
US National Institute of Allergy and Infectious Diseases · grant
Summary Antimicrobial resistance (AMR) is a prominent healthcare threat with an estimated 4.95 million cases associated with bacterial AMR in 2019, and poses a particularly difficult challenge with regard to intracellular pathogens that hav…
Posted May 21, 2026
Structure and Function of the Nuclear Pore Complex by Cryogenic-EM
US National Institute of General Medical Sciences · grant
Structure and Function of the Nuclear Pore Complex by Cryogenic-EM Abstract The nucleus is compartmentalized by double membranes of the Nuclear Envelope (NE) and macromolecules must cross this barrier during cell growth and differentiation.…
Posted May 21, 2026
Molecular basis for functional S1PR1 antagonists in the treatment of comorbid migraine and temporomandibular disorders
US National Institute of Neurological Disorders and Stroke · grant
Project Summary/Abstract Overlapping pain conditions greatly exacerbate patients’ pain experience. This includes comorbid migraine and temporomandibular disorders (TMDs), which is associated with a reciprocal increase in their prevalence/se…
Posted May 21, 2026
Molecular basis for adenosine A3 receptor agonists in the treatment of migraine
US National Institute of Neurological Disorders and Stroke · grant
Project Summary/Abstract Despite recent advances with new therapies, a huge proportion of migraine patients are still unable to use established therapeutics. For many patients, treatments are not effective, even newly approved CGRP mAbs hav…
Posted May 21, 2026
Enhanced Biochemical Monitoring for Aortic Aneurysm Disease
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY Aortic Aneurysm (AA) represents a major cause of morbidity and mortality in the United States and continues to be a difficult management problem for cardiovascular surgeons. This disease weakens the vessel wall and leads to…
Posted May 21, 2026
Protocol Review and Monitoring System
US National Cancer Institute · grant
PROTOCOL REVIEW AND MONITORING SYSTEM ABSTRACT The Protocol Review and Monitoring System (PRMS) reviews and monitors all interventional cancer-related clinical trials at Huntsman Cancer Institute (HCI) and the University of Utah (U of U), p…
Posted May 21, 2026
A novel Th17-enhancing adjuvant and conserved antigen for protection against viral/bacterial co-infection
US National Institute of Allergy and Infectious Diseases · grant
We will develop a novel vaccine with broad efficacy against nontypeable Haemophilus influenzae (NTHi) strains following influenza A virus (IAV) infection. NTHi is one of the most common pathogens that cause secondary bacterial pneumonia fol…
Posted May 21, 2026
Chromosome Dynamics and Evolution
US National Heart Lung and Blood Institute · grant
- Mechanisms of non-Mendelian segregation through female meiosis To understand how meiotic drive elements achieve non-Mendelian segregation, we currently focus on selfish centromeres in mice. Expanded centromeric satellite repeats can viol…
Posted May 21, 2026
Synthesizing Trial and Real-world Data on the Use of Biologics in Patients with Severe Asthma
US National Institute on Minority Health and Health Disparities · grant
Project Summary/Abstract African-Americans and Hispanics of Puerto-Rican origin bear a disproportionate burden of asthma morbidity and mortality, despite decades of attention to asthma disparities. The advent of biologic therapies offers a …
Posted May 21, 2026
Emulating hypothetical target trials to establish the comparative effectiveness of biologics in asthma
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY/ABSTRACT Asthma is a leading cause of morbidity in the US and worldwide, affecting almost 10% of the US population. Individuals with severe asthma, who are uncontrolled on conventional therapy, account for a disproportionate…
Posted May 21, 2026
The Impacts of Mitigation Strategies to Prevent COVID-19 Transmission in American Indian Communities
US National Institute on Minority Health and Health Disparities · grant
OTHER PROJECT INFORMATION – Project Summary/Abstract The Impacts of Mitigation Strategies to Prevent COVID-19 Transmission in American Indian Communities Very little is known about the impact of locally-mandated COVID-19 mitigation policies…
Posted May 21, 2026
Collaborative Pediatric Critical Care Research Network - Clinical Site
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
PROJECT SUMMARY/ABSTRACT – Baylor College of Medicine/Texas Children's Hospital The goals of the current proposal are to reorganize and expand the Collaborative Pediatric Critical Care Research Network (CPCCRN), to mentor young investigator…
Posted May 21, 2026
Robust and Efficient Learning of High-Resolution Brain MRI Reconstruction from Small Referenceless Data
US National Institute of Biomedical Imaging and Bioengineering · grant
PROJECT SUMMARY/ABSTRACT Neuropsychiatric (mental, behavioral and neurological) disorders are increasingly dominating the burden on US healthcare. Yet, our understanding of such disorders is largely restricted to a description of symptoms, …
Posted May 21, 2026
ECG-AI Based Prediction and Phenotyping of Heart Failure with Preserved Ejection Fraction
US National Heart Lung and Blood Institute · grant
Project Summary/Abstract More than 6 million adults are suffering from heart failure in the United States. Heart failure is associated with high mortality rate while also reducing the quality of life. Early recognition of heart failure and …
Posted May 21, 2026
Early Identification of Childhood Cancer Survivors at High Risk for Late Onset Cardiomyopathy: An Artificial Intelligence Approach utilizing Electrocardiography
US National Cancer Institute · grant
Project Summary/Abstract Due to improved treatment and supportive care, five-year survival rates for childhood cancer now exceed 85%. However, patients treated with anthracycline chemotherapy or chest-directed radiation have a dose-related …
Posted May 21, 2026
Overcoming Therapy Resistance in SCLC
US National Cancer Institute · grant
PROJECT SUMMARY/ABSTRACT Small cell lungcancer (SCLC) is a pulmonary neuroendocrine cancer with very poor prognosis and limited effective therapeutic options. Chemotherapy has been used for the past 30 years as for the treatment for SCLC. W…
Posted May 21, 2026
Single molecule functional validation of neurogenomic alterations in opioid-exposed HIV brain
US National Institute on Drug Abuse · grant
Neurogenomic studies by the SCORCH (Single Cell Opioid Response in the Context of HIV) consortium strongly suggest that brains of individuals living with HIV in the context of opioid or (polys)substance use disorder (OUD/SUD) comorbidity ha…
Posted May 21, 2026
Modeling HIV Microglia-Associated Infection and Inflammation in a Chimeric Mouse Brain
US National Institute on Drug Abuse · grant
HIV-associated neurocognitive disorders persist in the era of combination antiretroviral therapy (cART) while HIV latency, and cell-specific expression of HIV transcript in human CNS remains incompletely understood. There is high prevalence…
Posted May 21, 2026
Single nuclei transcriptome profiling in addiction circuitry of the HIV+ brain
US National Institute on Drug Abuse · grant
HIV-associated neurocognitive disorders (HAND) persist in the era of combination antiretroviral therapy (cART). HIV latency, and cell-specific expression of HIV transcript in human CNS remains incompletely understood, despite continued high…
Posted May 21, 2026
Single Chromatin Fiber Sequencing and Longitudinal Epigenomic Profiling in HIV+ Brain Cells Exposed to Narcotic and Stimulant
US National Institute on Drug Abuse · grant
HIV-associated neurocognitive disorders persist in the era of combination antiretroviral therapy (cART) while HIV latency, and cell-specific expression of HIV transcript in human CNS remains incompletely understood. There is high prevalence…
Posted May 21, 2026