Live opportunities

20,086 contracts

🏛Federal 🗽State 🏞County 🏙City 🎓Schools 🚇Districts 📚Universities
Showing 25 / 20086 · page 133/804
Estimating the Seroincidence of Melioidosis, Typhoid Fever and Scrub Typhus from Cross-sectional Serosurveys
US John E. Fogarty International Center for Advanced Study in the Health Sciences · grant
SUMMARY/ABSTRACT This mentored International Research Scientist Development Award (K01) from UC Davis and Mahidol University-Thailand will support Dr. Kristen Aiemjoy, Assistant Professor of Epidemiology, to establish an impactful, independ…
Posted May 21, 2026
Testing effects of cash transfers on biological aging and risk for Alzheimer's Disease
US National Institute on Aging · grant
Alzheimer's Disease (AD) and AD-Related Disorders (AD/ADRD) are significantly increasing in resource-limited areas, where improved nutrition and decreased infectious disease mortality are enabling population aging. Simultaneously, enduring …
Posted May 21, 2026
Defining and targeting CIC::DUX4-dependent survival in fusion-positive sarcomas
US National Cancer Institute · grant
Abstract The same intensity applied to identifying molecular targets, investing in research, and running clinical trials that is occurring now for adult cancers has not extended to the pediatric population, despite evidence that doing so i…
Posted May 21, 2026
Tear protein biomarkers of refractive surgery pain
US National Eye Institute · grant
PROJECT SUMMARY Photorefractive keratectomy (PRK) and laser-assisted in situ keratomileusis (LASIK) are surgical procedures used to correct refractive errors, with approximately 600,000 surgeries performed in the United States each year. A …
Posted May 21, 2026
Mechanisms of Pain and Photophobia in Migraine and Dry Eye
US National Eye Institute · grant
Project Summary Ocular pain and photophobia are common and debilitating conditions associated with migraine and dry eye disease (DED). Persistent pain, dry eye, and/or photophobia are also experienced by nearly 40% of patients who have rece…
Posted May 21, 2026
Spreading Depolarization and Progression of Developmental Epileptic Encephalopathy
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY Spreading depolarization (SD) is a wave of massive, near-complete cellular depolarization that slowly propagates across brain tissue. Recent decades of clinical studies have convincingly demonstrated that this prolonged depo…
Posted May 21, 2026
Mechanistic characterization of JNK2α variants in alcohol-caused heart failure
US National Institute on Alcohol Abuse and Alcoholism · grant
Long-term excessive alcohol consumption leads to a significant prevalence of alcoholic cardiomyopathy (ACM) that is characterized by impaired cardiac function (heart failure, HF) in the absence of other cardiovascular diseases. During the C…
Posted May 21, 2026
The JNK2-NLRP3 nexus in atrial fibrillation and its anti-AF therapeutic potentials
US National Institute on Alcohol Abuse and Alcoholism · grant
Excessive binge alcohol intake is a well-recognized risk factor for atrial fibrillation (AF), the most common arrhythmia with a high morbidity and mortality, yet current therapies have suboptimal effectiveness. [While aging is an unavoidabl…
Posted May 21, 2026
Atrial and blood JNK in Postoperative AF
US National Heart Lung and Blood Institute · grant
Atrial fibrillation (AF) is the most common arrhythmia and has a high risk of mortality and morbidities. Among the general AF population, new-onset postoperative atrial fibrillation (POAF) is the most common complication after open- heart s…
Posted May 21, 2026
Does age matter for the development of pathogenic T helper 2 resident memory cells in the lung?
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY Allergic asthma is a chronic inflammatory disease that often progresses from childhood to adulthood. Approximately 8% of the world population suffer from allergic asthma, making it one of the most common respiratory diseases…
Posted May 21, 2026
Targeting cell fusion as a novel strategy to tackle JQ1 resistance in triple negative breast cancer
US National Institute of General Medical Sciences · grant
Triple negative breast cancer (TNBC) remains an aggressive disease due to the lack of targeted therapies and low rate of response to chemotherapy that is currently the main treatment modality. Compared to other types of breast cancer, TNBC …
Posted May 21, 2026
Fluorescent Indicators for Imaging Synaptic Zinc in Cortical Sound Processing
US National Institute of Biomedical Imaging and Bioengineering · grant
Abstract Although the importance of synaptic Zn2+, as an emerging neuromodulator throughout the brain, has been widely appreciated, the dynamics of synaptic Zn2+ release in response to naturally occurring stimuli remains largely elusive. Ge…
Posted May 21, 2026
Fluorescent Redox Indicators to Image Oxidative Stress in Alzheimer's Disease
US National Institute on Aging · grant
Abstract Alzheimer's disease (AD) and other age-related neurodegenerative disorders have become a global health and social challenge. Although the exact cause of AD is still under investigation, among various AD hypotheses, oxidative stress…
Posted May 21, 2026
Next-Generation ATP-Independent Luciferases, Luciferins, and Bioluminescent Calcium Indicators
US National Institute of Biomedical Imaging and Bioengineering · grant
Abstract: In 2012, Promega introduced NanoLuc, an ATP-independent marine luciferase mutant exhibiting a high photon production rate in the presence of a synthetic luciferin analog, furimazine. However, NanoLuc has several unfavorable featur…
Posted May 21, 2026
Mechanistic clinical trial of blocking the IL-4/13 axis in asthmatics precision phenotyped in an aeroallergen challenge chamber before, during and after receipt of dupilumab
US National Institute of Allergy and Infectious Diseases · grant
7. Project Summary/Abstract We propose a high-impact, randomized, double-blind, placebo-controlled, mechanistic clinical trial aimed at elucidating the basis for the wide heterogeneity in severity of and treatment responses in persons with …
Posted May 21, 2026
Mechanisms of Cellular Communication: The Role of Merlin in Pancreatic Development
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY More than 30 million Americans have pre- or existing diabetes. An innovative approach to treat diabetes is to generate functional insulin-producing -cells for transplantation in vitro. This approach is currently in clinical…
Posted May 21, 2026
Summer Undergraduate Addiction Research Training Program in Central Appalachia
US National Institute on Drug Abuse · grant
PROJECT SUMMARY/ABSTRACT The Central Appalachian region is a rural area that has some of the highest rates of opioid related mortality in the U.S. It is essential to fully understand factors contributing to these challenges and identify sol…
Posted May 21, 2026
2/2 Bangladesh Center for Global Environmental and Occupational Health-US
US John E. Fogarty International Center for Advanced Study in the Health Sciences · grant
ABSTRACT: This is the renewal U2R application for the “Bangladesh Center for Global Environmental and Occupational Health (GEOHealth)”- awarded along with the linked U01 grant in 2015 to the University of Chicago (UofC) and International Ce…
Posted May 21, 2026
The Illinois Precision Medicine Consortium (IPMC) All of Us Research Program Site
US NIH Office of the Director · grant
The All of Us Research Program (AoURP) Illinois Precision Medicine Consortium (IPMC) award has created an impetus for precision health collaboration in Illinois that will leave a positive legacy for decades both locally and nationally. Sinc…
Posted May 21, 2026
Personalized prime editing as a platform for hepatic inborn errors of metabolism
US National Center for Advancing Translational Sciences · grant
PROJECT SUMMARY Inborn errors of metabolism (IEMs) are rare, devasting disorders arising from pathogenic variants in genes encoding enzymes of key biochemical pathways. The liver plays an important role in the pathogenesis of over 150 IEMs,…
Posted May 21, 2026
Network modulation to improve gene therapy in CLN3 disease
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY Two-thirds of lysosomal storage disorders (LSD) affect the brain, yet most LSD treatments do not improve central nervous system (CNS) symptoms. Several trials of brain-directed gene therapy have failed to show clinical benef…
Posted May 21, 2026
Imaging tumor-associated macrophages in head and neck squamous cell carcinoma using fluorine-19 MRI
US National Cancer Institute · grant
In this project, we aim to translate a fluorine-19 (19F) MRI technology to visualize the tumor associated macrophage (TAM) burden in patients with recurrent head and neck squamous cell carcinoma (HNSCC). HNSCC is the sixth most common cance…
Posted May 21, 2026
Metallo-fluorocarbon nanoemulsion for PET detection of cancer inflammation
US National Cancer Institute · grant
In cancer, macrophages play a multifaceted role in disease progression and response to therapies. Tumor- associated macrophages (TAMs) serve several pro-tumoral functions including the expression of factors promoting growth, immune suppress…
Posted May 21, 2026
Understanding the relationship between individual, social, and structural determinants of health, mobility, and HIV outcomes among adolescents and young adults living with HIV in Tennessee
US National Institute on Minority Health and Health Disparities · grant
Modified Abstract Section ABSTRACT Adolescents and young adults living with HIV (AYA-HIV) face the highest HIV incidence and poorest care outcomes among all age groups of people living with HIV (PWH) in the United States. Mobility has emerg…
Posted May 21, 2026
An interactive, narrative intervention to address the mental health treatment gap among young people living with HIV in Nigeria
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
PROJECT SUMMARY Young people living with HIV (Y-PLWH) have poor adherence to antiretroviral therapy and engagement in HIV care, making HIV the leading cause of death for African adolescents. Depression and psychological distress are much mo…
Posted May 21, 2026