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Showing 25 / 20086 · page 56/804
Biomarker Core
US National Institute on Aging · grant
REVISED PROJECT SUMMARY – BIOMARKER CORE The overall goal of the Biomarker Core is to collect, bank, and distribute fluid biospecimens and to generate and share extensive biomarker datasets with the scientific community to address the heter…
Posted May 21, 2026
Intersection of Uremic Toxins and Biological Sex in Chronic Kidney Disease Progression
US National Institute of General Medical Sciences · grant
Children with chronic kidney disease (CKD) are at high risk of complications and have a reduced life expectancy compared to healthy peers. The risk of complications and death increases as CKD progresses to higher stages. Childhood CKD is …
Posted May 21, 2026
Effects of Poly(ethylene glycol) Immunogenicity on Implant Biocompatibility
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY Poly(ethylene glycol) (PEG) based hydrogels are widely used in medical devices and are being studied for the delivery of protein and cellular therapeutics. While these biomaterials are widely regarded as biologically inert, …
Posted May 21, 2026
Addressing negative social experiences through coping and resilience to reduce methamphetamine use and improve PrEP cascade progression among Latino MSM
US National Institute on Drug Abuse · grant
Negative social experiences are a main driver of HIV disparities among Latino men who have sex with men (LMSM), negatively affecting non-injection substance use (e.g. methamphetamine) and PrEP uptake. Addressing factors that influence PrEP …
Posted May 21, 2026
Understanding the relationship between cortical hyperexcitability and the progression of FTD/ALS pathology and behavioral deficits in mice
US National Institute on Aging · grant
Frontotemporal dementia (FTD) is a progressive neurodegenerative disorder that causes severe personality and behavior changes. A hexanucleotide repeat expansion in the C9orf72 gene is FTD's most common genetic cause. I aim to elucidate the …
Posted May 21, 2026
High-Throughput In Vitro Analyses of Trauma-Induced Tauopathy
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repeated mild traumatic brain injury (TBI). CTE is among the many neurodegenerative diseases characterized as tauopathies, wherein the pro…
Posted May 21, 2026
Role of mechanical heterogeneity in cerebral aneurysm growth and rupture
US National Institute of Neurological Disorders and Stroke · grant
Cerebral aneurysms (CAs) are out-pouching dilations of cerebral arteries caused by local wall weakening and maladaptive remodeling. Though rupture is relatively rare, the post-rupture survival rate is low, due to complications such as vasos…
Posted May 21, 2026
SBIR TOPIC 111, PHASE II: A COMPACT PORTABLE MEDICAL OXYGEN GENERATOR
US National Heart Lung and Blood Institute · grant
NHLBI has developed the Myocardial Intramural Restraint by endovenous interstitial teTHer (MIRTH) procedure and the related Suture via Coronary sinus with Interstitial myocardial navigation for MItral and Tricuspid Annular Reduction (SCIMIT…
Posted May 21, 2026
Unlocking New Chemistries in Extant Enzymes for Synthesizing Bioactive Molecules
US National Institute of General Medical Sciences · grant
Project Summary/Abstract: Enzymes, supported by their macromolecular structure, can catalyze chemical transformations with exquisite control, delivering products with high selectivity. The mechanisms that enzymes can support, however, are l…
Posted May 21, 2026
Colonoscopy augmentation with Fluorescence Lifetime Imaging (FLIm): colorectal cancer detection in humans
US National Cancer Institute · grant
PROJECT SUMMARY Colorectal cancer (CRC) is the second leading cause of cancer-related mortality globally, with current screening techniques, such as colonoscopy, demonstrating limitations in accurately detecting subtle structural abnormalit…
Posted May 21, 2026
Natural history of multisystem proteinopathy-1
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY (Project 4: Natural History of MSP1) This proposal’s primary objective is to validate a promising measure of motor function as a future efficacy out- come in a large cohort of patients with multisystem proteinopathy 1 (MSP1)…
Posted May 21, 2026
ADAM10 as a molecular specifier of sepsis
US National Institute of Allergy and Infectious Diseases · grant
PROJECT ABSTRACT This proposed career development award will provide Dr. Danielle Alfano, MD with targeted mentored training to ensure she develops into an independent researcher utilizing both experimental approaches, mouse models, and “om…
Posted May 21, 2026
Production and Validation of monoclonal antibodies to enhance rigor and reproducibility in research vertebrate animal model
US NIH Office of the Director · grant
Project Summary Animal models are critical for biomedical research. They allow us to rapidly test the importance of any gene for development or diseases. Advances in technology now allow us to reduce or eliminate protein expression in the e…
Posted May 21, 2026
IL-1R1 in Endothelial-to-Mesenchymal Activation
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY: Endothelial-to-mesenchymal transition (EndMT) has been detected in atherosclerosis, and the extent of EndMT observed in the human plaques strongly correlates with the severity of the disease, implying clinical relevance of …
Posted May 21, 2026
DelPhi and associated resources: maintenance, development and applications
US National Institute of General Medical Sciences · grant
We are a computational lab and our research is within the areas of Computational Biophysics, Bioinformatics, and modeling molecular effects associated with disease-causing mutations. We develop methods, software, and webservers to enable mo…
Posted May 21, 2026
Epigenomic mechanisms of cardiac fibrosis and heart failure
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY A heart failure diagnosis leads to poor quality of life and a 5-year mortality nearing 50%, underscoring the urgent need for innovative treatments. Clinical evidence strongly links myocardial fibrosis, driven by pathological…
Posted May 21, 2026
Chromatin Regulation of Immune Cells in Myocardial Inflammation
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY Ischemic heart disease following myocardial infarction (MI) is a leading cause of global morbidity and mortality. During MI, infiltrating immune cells, particularly monocytes, differentiate into macrophages, adopting both re…
Posted May 21, 2026
Innovative Transformations of Fundamental Synthetic Building Blocks
US National Institute of General Medical Sciences · grant
Project Summary: The value of chemical synthesis in health-related research is closely tied to the ability to efficiently generate medicinal agents from readily available materials. This MIRA application seeks to continue our efforts center…
Posted May 21, 2026
Mapping immuno-genomic drivers of the head and neck precancer invasive-disease transition
US National Cancer Institute · grant
PROJECT SUMMARY Globally, more than 900,000 people are diagnosed with head and neck squamous cell carcinoma (HNSCC) each year, with more that 250,000 dying annually from this cancer. Infection with human papilloma virus (HPV), a known risk …
Posted May 21, 2026
Detecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer Prevention
US National Institute of Environmental Health Sciences · grant
PROJECT SUMMARY Somatic mutations accumulate daily in every cell of the human body. These mutations originate from mutational processes due to environmental exposures, lifestyle choices, defective cellular machineries, and even normal cellu…
Posted May 21, 2026
Forward Genetic Analysis of Human Nuclear Long Non-Coding RNAs
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY Certain human nuclear long non-coding RNAs (lncRNAs) represent well-established promising targets for the treatment of cancer, developmental and viral diseases; manipulating their levels is expected to provide therapeutic in…
Posted May 21, 2026
Investigating the mechanism of decision-making in the mitochondrial Protease YME1
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY YME1 is an ATP-dependent protease located in the inner mitochondrial membrane, and plays a central role in executing the functional activities of the mitochondrial protein quality control network. Preserving homeostasis with…
Posted May 21, 2026
2025 Label-Free Single Molecule Sensing Gordon Research Conference
US National Institute of Biomedical Imaging and Bioengineering · grant
Project Summary The ability to precisely detect biomolecules and measure their dynamics is central to our understanding of the origins of debilitating diseases such as Alzheimer’s and Parkinson’s and is a prerequisite for designing more eff…
Posted May 21, 2026
The interplay of maternal antibody and newborn vaccine responses
US National Institute of Allergy and Infectious Diseases · grant
Young infants are at high risk for severe disease following influenza virus infection. The current strategy for protecting infants is to increase antibody in the mother that can be transferred across the placenta to the fetus such that infa…
Posted May 21, 2026
Regulation of the HA stem nanoparticle vaccine response by antigen duration
US National Institute of Allergy and Infectious Diseases · grant
The immune system of young infants exhibits profound alterations compared to that of older children and adults. Notable among these are lower responses to TLR engagement, reduced dendritic cell maturation, reduced Tfh responses, and a stron…
Posted May 21, 2026