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Showing 25 / 20086 · page 63/804
Physical Activity, Energy Balance, and Cancer
US National Cancer Institute · grant
The goals will be achieved by a) evaluating obesity, energy balance, and physcial activity in relation to cancer incidence and survival; b) Improving assessment of energy intake, output, and body phenotype; c) Evaluating biomarkers to deter…
Posted May 21, 2026
Prostate Cancer Studies
US National Cancer Institute · grant
In Ghana, Africa, we have conducted a population-based survey of men to assess the population prevalence of prostatic disease (CAS ID:01130). We have also collected consented into the study a clinical series of men diagnosed with prostate c…
Posted May 21, 2026
Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study
US National Cancer Institute · grant
The ATBC Cohort Follow-up Study has been in place since 1994. Male smokers between the ages of 50 and 69 were recruited from southwestern Finland between April 1985 and June 1988. A total of 29,133 men were randomly assigned to one of four…
Posted May 21, 2026
Early, non-invasive detection of pulmonary vascular dysfunction in acute respiratory distress syndrome
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY. Acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure associated with substantial in-hospital mortality. ARDS patients with pulmonary vascular dysfunction (PVD) are a particularly high-risk sub…
Posted May 21, 2026
Dissecting the cellular interplays of adipose tissue remodeling in the regulation of insulin sensitivity
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY/ABSTRACT This proposed career development award will provide Dr. Diana Alba MD with targeted mentored training to ensure she develops into an independent researcher utilizing both experimental approaches and models, and “omi…
Posted May 21, 2026
Decentralizing Breast Biopsy Procedures for Early Cancer Diagnosis In Rwanda
US John E. Fogarty International Center for Advanced Study in the Health Sciences · grant
PROJECTS SUMMARY/ABSTRACT BACKGROUND: With 2.3 million new cases per year, breast cancer is among the most diagnosed cancers in women globally and is the leading cause of cancer mortality in low-and middle-income countries (LMICs), includin…
Posted May 21, 2026
Wireless Metamaterial Interbody Cage for Real-Time Assessment of Lumbar Spinal Fusion In Vivo
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
PROJECT SUMMARY Current technology is constrained by a lack of specificity and sensitivity for wireless force sensing during spinal fusion. The conventional methods for acquiring force-sensing data from smart wireless spinal implants requir…
Posted May 21, 2026
Investigating the effect of mechanical compliance of metamaterial interbody cages on spinal fusion progress in vivo
US National Institute of Biomedical Imaging and Bioengineering · grant
PROJECT SUMMARY There is an unmet need for understanding the complex relationships between the compliance of interbody fusion cages, interbody loading, load-sharing, and the progression of spinal fusion in vivo. Interbody fusion cages are s…
Posted May 21, 2026
REACH Pipeline Summer Research Experience for Minority and Underrepresented High School and Undergraduate Students
US National Institute of Neurological Disorders and Stroke · grant
REACH is an 8-week pipeline summer course for minorities and underrepresented college and high school students interested in careers in neuroscience. Developed, together with Drs. Jenny Libien, MD, Ph.D., and Juan Marcos Alarcon, Ph.D., the…
Posted May 21, 2026
Dual Fatty Acid Amide Hydrolase (FAAH)/Monoacylglycerol lipase (MAGL) Inhibitors for Cannabis Use Disorder (CUD).
US National Institute on Drug Abuse · grant
OTHER PROJECT INFORMATION – Unit 7 – Project Summary/Abstract Abstract This project addresses the growing need for medications for cannabis use disorder (CUD) which, in the absence of approved medications, is a major focus of NIDA’s mission…
Posted May 21, 2026
Culturally Tailored Nutrition Therapy To Improve Dietary Adherence of Type 2 Diabetes Patients in Benin, Africa
US John E. Fogarty International Center for Advanced Study in the Health Sciences · grant
ABSTRACT Effective medical nutrition therapy (MNT) is needed to stem the alarming increase in Type 2 diabetes (T2D) related morbidity and mortality in Benin, a French sub-Saharan African (SSA) country, where diabetes prevalence has quadrupl…
Posted May 21, 2026
Roles for Mismatch Repair Proteins in Maintaining Genome Stability
US National Institute of General Medical Sciences · grant
Mismatch repair (MMR) factors, which act to remove DNA replication misincorporation errors, also function in genetic recombination and in adaptation to stress. The latter two roles are the current focus of my research efforts. Research Area…
Posted May 21, 2026
A Novel Semi-autonomous Surgeon-in-the-loop in situ Robotic Bioprinting System for Functional and Cosmetic Restoration of Volumetric Muscle Loss Injuries
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Summary/Abstract: Our long-goal is to develop an unprecedented semi-autonomous surgeon-in-the-loop surgical robotic system and complementary computer-assisted algorithms to enable an intuitive in situ robotic bioprinting of human tissues an…
Posted May 21, 2026
Molecular signaling mechanisms controlling Cryptosporidium proliferation and development
US National Institute of Allergy and Infectious Diseases · grant
Project Abstract Cryptosporidium is a leading cause of diarrheal disease (cryptosporidiosis) and death among young children living in resource-poor settings. In the US, Cryptosporidium is the major cause of waterborne outbreaks linked to re…
Posted May 21, 2026
Role of Cryptosporidium effectors in host actin manipulation
US National Institute of Allergy and Infectious Diseases · grant
Project Abstract The protozoan parasite Cryptosporidium is a leading cause of diarrheal disease (cryptosporidiosis) and death in young children and immunocompromised individuals. Currently, there are no vaccines or effective drugs to preven…
Posted May 21, 2026
Antigen recognition and activation of HIV-specific B cell antigen receptors
US National Institute of Allergy and Infectious Diseases · grant
Abstract B cell antigen receptor (BCR)-antigen interactions that govern the activation of B cells with a pre-vaccinated B- cell repertoire are not clearly defined for HIV-1 broadly neutralizing antibody (bnAb) lineages. Our recent studies s…
Posted May 21, 2026
DNA induction of neutrophilic asthma
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY Neutrophilic asthma is a subtype of severe asthma, which has no safe and effective therapy. There is an unmet need to delineate the mechanism of neutrophilic asthma and develop targeted and effective therapies. Host cell-der…
Posted May 21, 2026
Preoptic/Hypothalamic Mechanisms of Sleep-Wake Regulation
US Veterans Affairs · grant
An estimated 54.1 million Americans, including 18.2 million Veterans (49% of the Veteran population), are elderly and at higher risk for developing chronic sleep disturbance. Chronic insufficient or disrupted sleep is associated with a spec…
Posted May 21, 2026
Distributed foundational models for multi-task learning in diabetic retinopathy
US National Eye Institute · grant
Abstract: This project aims to establish distributed federated learning (FL) approaches for multi-task training of foundational machine learning (ML) models for diabetic retinopathy (DR), using multi-modal, real-world optical coherence tomo…
Posted May 21, 2026
Alam Project
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY – PROJECT 7 (ALAM) Campylobacter jejuni is the primary pathogen responsible for bacterial gastrointestinal infections worldwide and is the leading cause of enteric inflammation in the United States, which can further lead to…
Posted May 21, 2026
A Phase 2b Clinical Study of the P38 Alpha Kinase Inhibitor Neflamapimod in Patients with Mild-to-Moderate Dementia with Lewy Bodies (DLB)
US National Institute on Aging · grant
Dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia after Alzheimer’s disease (AD). DLB is a more rapidly progressive disease than AD, with a median time from diagnosis to death or nursing home admi…
Posted May 21, 2026
Molecular basis of fatty acid transport by peroxisomal ABC transporters
US National Institute of General Medical Sciences · grant
Project Summary Peroxisomal ABC transporters like ABCD1, ABCD2, and ABCD3 shuttle very long chain fatty acids (VLCFAs), branched chain fatty acids (BCFAs), and bile acid precursors into peroxisomes. Their functional impairment leads to seve…
Posted May 21, 2026
Functional analysis of a novel cell envelope integrity protein in Brucella ovis
US National Institute of Allergy and Infectious Diseases · grant
Abstract The long-term goal of this research is to determine how bacteria maintain cell envelope integrity in the face of harsh and fluctuating environmental conditions. The cell envelope of Gram-negative bacteria is composed of the cytopla…
Posted May 21, 2026
Genetic dysregulation of mRNA translation in type 1 diabetes
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Project Summary/Abstract Type 1 diabetes (T1D), which is characterized by T cell-mediated destruction of insulin-producing pancreatic beta cells, has a relatively well-defined genetic architecture that explains about 50% of inter-individual…
Posted May 21, 2026
Initiation of DNA Replication in Mammalian Cells
US National Cancer Institute · grant
Our studies focus on cellular signaling pathways that regulate cell proliferation, focusing on the location, timing and progression of DNA synthesis in cancer cells. Since many regulatory pathways that affect chromosome duplication are dere…
Posted May 21, 2026