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Showing 25 / 20086 · page 57/804
Training Program in Immunology and Pathogenesis
US National Institute of Allergy and Infectious Diseases · grant
This renewal application requests continued funding for years 31-35 of a successful, longstanding program for predoctoral training in Immunology and Pathogenesis. Four predoctoral positions are requested. Trainees are typically supported …
Posted May 21, 2026
Precision brain charts for imaging-genomics of schizophrenia and the psychosis spectrum
US National Institute of Mental Health · grant
ABSTRACT An unmet need for psychiatric neuroimaging is a standard developmental frame of reference to benchmark studies of neurodevelopmental conditions such as schizophrenia the psychosis spectrum (PS). Using a modelling approach that has …
Posted May 21, 2026
Radiomics for Clinically-Acquired Brain MRIs of Youth with Neurodevelopmental Disorders
US National Institute of Mental Health · grant
PROJECT ABSTRACT The millions of brain MRIs acquired each year in clinical settings are a vastly underutilized scientific resource. Meanwhile, brain MRIs collected in research studies often struggle to recruit cohorts fully representative o…
Posted May 21, 2026
The Genetics of Personalized Functional MRI Networks
US National Institute of Mental Health · grant
ABSTRACT Variability in the spatial layout of human brain functional networks on the anatomic cortex is a novel phenotype that can be extracted from functional magnetic resonance imaging (fMRI) with transformative potential for combined ima…
Posted May 21, 2026
The Role of Post-Translational Modifications in Bacterial Responses to Methylglyoxal
US National Institute of General Medical Sciences · grant
Project Summary and Abstract Methylglyoxal (MGO) is a highly reactive, toxic molecule that is produced non-enzymatically during central metabolism by virtually all cells. Some microorganisms, including enteric bacteria such as Escherichia c…
Posted May 21, 2026
The Effects of Cue Precision on Medical Imaging Interpretation
US National Institute of General Medical Sciences · grant
PROGRAM SUMMARY: It is undesirable for radiologists to search for only one specific thing at a time, as they may miss unexpected findings. Despite this, there is evidence that prior knowledge and expectations (from clinical history or other…
Posted May 21, 2026
Alzheimer's Prevention Initiative ADAD Colombia Trial Program
US National Institute on Aging · grant
Project Summary/Abstract When the API Autosomal Dominant Alzheimer's Disease (ADAD) Colombia Trial (NCT01998841) was announced in 2012, it launched a new era in AD prevention research. The trial led us to identify ~6,000 persons from the wo…
Posted May 21, 2026
Dystrophin as a novel regulator of the circadian clock in skeletal muscle and the brain
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY/ABSTRACT Duchenne muscular dystrophy (DMD) is a severe and progressive neuromuscular disease that affects 1:5000 live male births, making it the most common form of muscular dystrophy. DMD is caused by the disruption of the …
Posted May 21, 2026
Molecular and therapeutic correction of XMEA using novel zebrafish and mouse models
US National Center for Advancing Translational Sciences · grant
PROJECT SUMMARY/ABSTRACT The objective of this proposal is to define the molecular mechanisms and identify new therapeutic strategies for of an understudied class of myopathies, specifically X-linked myopathy with excessive autophagy (XMEA)…
Posted May 21, 2026
Role of isoLGs and neutrophils in psoriasis-induced renal dysfunction and hypertension
US National Heart Lung and Blood Institute · grant
Project Summary Psoriasis is a prevalent autoimmune disease involving formation of scaly and pruritic plaques on the skin. Although these skin lesions cause significant negative physical and psychosocial effects, the major morbidity and mor…
Posted May 21, 2026
Deconstructing interactions between diet, microbiome, and immunity to gain mechanistic insight into health and disease
US National Institute of Allergy and Infectious Diseases · grant
Project Summary/Abstract Intestinal immune responses are linked to the trillions of microorganisms that colonize the gastrointestinal tract. Thus, inter-individual variations in the gut microbiome could contribute to altered immune response…
Posted May 21, 2026
Mechanisms and interventions addressing accelerated cardiovascular disease risk in women with endometriosis
US National Heart Lung and Blood Institute · grant
Endometriosis and is a debilitating estrogen-dependent gynecological disorder deriving from the presence of endometrium like tissue in sites outside the uterine cavity. Approximately 6-10% of women have endometriosis and suffer from symptom…
Posted May 21, 2026
Principles of Speckle-Based Gene Regulation
US National Cancer Institute · grant
The cell nucleus houses different types of non-DNA substructures, called nuclear bodies. Among these, nuclear speckles predominate. Speckles occupy ~15-30% of the nuclear volume and are present in cells throughout our bodies. Proteins invol…
Posted May 21, 2026
PREVENTABLE Administrative and Trial Management
US National Institute on Aging · grant
Duke Clinical Research Institute (DCRI) and Wake Forest School of Medicine (WFSM) will combine their world-renowned expertise and exceptional resources to lead the PREVENTABLE trial. This trial will determine the role of a moderate-intensit…
Posted May 21, 2026
Empowering Support Persons to Enhance the Recovery Capital of Postpartum Women with Opioid Use Disorder
US National Institute on Drug Abuse · grant
Project Summary/Abstract Opioid agonist treatment (OAT) is highly effective in preventing morbidity and mortality related to opioid use disorder (OUD), but long-term engagement is complicated by physical, social, and structural factors, esp…
Posted May 21, 2026
Treating Polysubstance Use in Methadone Maintenance: Application of Novel Digital Technology
US National Institute on Drug Abuse · grant
Abstract Methadone is a highly effective treatment for opioid use disorder (OUD), but many patients leave treatment prematurely, placing them at high risk of relapse and overdose. Extensive research shows that comorbid cocaine use is associ…
Posted May 21, 2026
A Patient Navigation Trial for Housing and Health (PATHH): A randomized controlled trial
US National Institute of Nursing Research · grant
Nearly one in three women have experienced physical or sexual violence. Women who have survived violence (WSV) demonstrate high rates of housing instability and health problems, including increased morbidity and mortality related to substan…
Posted May 21, 2026
Implementing a patient navigation intervention across a health system to improve outcomes for patients with opioid use disorder
US National Institute on Drug Abuse · grant
Opioid agonist treatment (OAT) is protective against overdose, yet less than 20% of people with opioid use disorder (OUD) engage in such treatment. Hospital utilization is high among people with OUD and can be a ‘reachable moment’ to initia…
Posted May 21, 2026
Exploring a Novel Myeloid Subset for Transporting Polyomavirus to the CNS
US National Institute of Neurological Disorders and Stroke · grant
Abstract JC polyomavirus (JCPyV) is the causative agent of the often-fatal demyelinating brain disease Progressive multifocal leukoencephalopathy (PML). While 70-90% of adults carry JCPyV lifelong, only after immunosuppression is the virus …
Posted May 21, 2026
New cross-sectional and longitudinal data for the study of aging: 1960 full-count U.S. Census
US National Institute on Aging · grant
SUMMARY This project will digitize and disseminate the only remaining non-digitized U.S. census records between 1790 and the present: the 1960 full-count Census. We will then use the resulting microdata to complete the largest longitudinal …
Posted May 21, 2026
Data Sharing and Archiving for Demographic Research - Supplement #2 (NICHD)
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Project Summary/Abstract Data Sharing for Demographic Research (DSDR) is a Population Health Data Archive that makes research data with external validity available for secondary analysis. These data enable researchers to make valid inferen…
Posted May 21, 2026
Increasing the Quality and Efficiency of Clinical Trials (U18)
US · IL National Institutes of Health (NIH) · grant
Despite myriad innovations in design, conduct, and supporting technologies, clinical trials are becoming more complex, keeping them prohibitively expensive and slow. As a result, the clinical trials ecosystem is not producing evidence about…
Posted May 21, 2026
Impact of Nursing Home Leadership Care Environments and Health Information Technology on Outcomes of Residents with Alzheimer's Disease and Related Dementias (ADRD)
US · IL NIH · grant
Our study examines the Impact of Nursing Home Leadership, Care Environments and Health InformationTechnology on Outcomes of Residents with Dementia. Approximately 42% of 1.3 million nursing home (NH) residents have dementia. NH residents wi…
Posted May 21, 2026
Core F: Biomarker Core
US National Institute on Aging · grant
PROJECT SUMMARY/ABSTRACT - BIOMARKER CORE The Biomarker Core (BC) will provide access across the Arizona ADRC to advance brain imaging, fluid, and wearable/digital biomarker expertise, resources, data, and specimens for application with our…
Posted May 21, 2026
Johns Hopkins Center of Excellence in Regulatory Science and Innovation
US Food and Drug Administration · grant
PROJECT SUMMARY/ABSTRACT As the world’s leading regulatory authority, and the country’s largest research university, the U.S. Food and Drug Administration and Johns Hopkins University are ideally suited to broaden and deepen their highly pr…
Posted May 21, 2026