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Showing 25 / 20086 · page 61/804
UM Clinical Neuroscientist Training Program
US National Institute of Neurological Disorders and Stroke · grant
Abstract There is a marked gap between our ability to treat neurologic diseases and our rapidly increasing understanding of normal nervous system function, disease pathogenesis, and disease pathophysiology. Improving treatment of neurologic…
Posted May 21, 2026
Personalizing Antimicrobial Use in Ventilator-Associated Pneumonia
US National Institute of Allergy and Infectious Diseases · grant
Candidate’s Long-Term Career Goals: To become an independent clinical investigator that strengthens ICU antimicrobial stewardship and personalizes antibiotic use in nosocomial pneumonia. Clinical Problems to be Addressed with this project: …
Posted May 21, 2026
Protein engineering for the development of novel antimicrobial agents
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY Antimicrobial resistance increasingly threatens our ability to effectively treat a wide range of infections. Absent the development of novel antibiotics, humanity faces the prospect of a return to the pre-antibiotic era with…
Posted May 21, 2026
TRPV1 nociceptors in oral carcinogenesis and pain
US National Cancer Institute · grant
Project Summary Oral cancer pain is more severe than all other cancers. Patients with metastatic oral cancer experience the greatest pain. Oral cancers activate neurons and produce pain; however, the effect of nociceptors on oral cancer is …
Posted May 21, 2026
Genetic and developmental mechanisms that underlie craniofacial (co)variation
US National Institute of Dental and Craniofacial Research · grant
Abstract/Summary: The vertebrate craniofacial skeleton is a dynamic organ that arises and is maintained through an intricate balance of genetic and environmental inputs. Disruptions to either can lead to deleterious health outcomes. While s…
Posted May 21, 2026
Role of Axonal Sprouting Mediated Network Reorganization in Stroke Recovery
US National Institute of Neurological Disorders and Stroke · grant
The goal of this mentored career development award is to facilitate the candidate’s transition to independence as a physician-scientist studying the molecular and neuronal mechanisms of stroke recovery. The candidate is an MD/PhD neurologis…
Posted May 21, 2026
Gene regulation and social relationships across the life course in a nonhuman primate model
US National Institute on Aging · grant
Project Summary Social support and social integration are some of the most robust predictors of morbidity and mortality identified to date. This relationship arises from increased susceptibility to several of the top causes of death in the…
Posted May 21, 2026
Comprehensive Augmented Reality Testing (CART) Platform for Parkinson’s disease
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY/ABSTRACT Parkinson’s disease (PD) is the fastest growing neurological disease, outpacing even Alzheimer’s. A gap in the effective treatment of PD is the reliance on capacity-based clinical assessments, such as the MDS-UPDRS …
Posted May 21, 2026
Neural Mechanisms underlying the benefits of Aerobic Exercise in Advanced Parkinson's disease
US National Institute on Aging · grant
PROJECT SUMMARY/ABSTRACT A substantial body of evidence supports the concept that high intensity aerobic exercise improves Parkinson’s disease (PD) symptomology in mild to moderate people with PD (PwPD). Despite advances in appreciating the…
Posted May 21, 2026
The Interplay between Genetics and Aerobic Exercise to Slow Parkinson's disease (GEARS) Trial
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY/ABSTRACT Despite advances in pharmaceutical and surgical approaches to the treatment of Parkinson’s disease (PD), an effective disease modifying treatment remains elusive. A growing body of evidence supports the notion that …
Posted May 21, 2026
Measuring and Modeling the Effects of Reticular Lamina Flexibility on Outer Hair Cell Bundle Phase and Cochlear Amplification
US National Institute on Deafness and Other Communication Disorders · grant
ABSTRACT The mammalian auditory system has evolved into a biological marvel with high sensitivity that can largely be traced to nonlinear amplification by the organ of Corti (OoC)—the sensory epithelium within the cochlea of the inner ear. …
Posted May 21, 2026
Administration of intratumoral immunocytokine to activate immune rejection of spontaneous canine melanoma
US Veterans Affairs · grant
Malignant melanoma is a serious health issue for Veterans, and metastatic melanoma is usually incurable if it metastasizes to distant sites. Exciting and impressive data with immune checkpoint blockade demonstrate the ability of the immune …
Posted May 21, 2026
A new animal model to elucidate mechanisms of gene regulation and embryonic patterning
US National Institute of General Medical Sciences · grant
Project Summary Hox genes serve as critical regulators of developmental processes. Disruption of their function during embryogenesis results in dramatic “homeotic” phenotypes where regions of the body are transformed from one identity to an…
Posted May 21, 2026
Distinct roles of U2AF1 mutations in myelodysplastic syndrome pathogenesis
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY/ABSTRACT This proposal outlines a 5-year training plan for the transition of the candidate to an independent investigator. The long-term goal of the candidate is to be a physician-scientist at an academic medical center stud…
Posted May 21, 2026
Community Engagement Research Core
US National Institute on Aging · grant
CERC Summary/Abstract The Community Engagement Research Core (CERC) supports research with older adults at all stages including training, design, conduct, and dissemination. CERC provides recruitment support to OAIC projects through its co…
Posted May 21, 2026
Leveraging social media to promote body positivity among Latino adolescents
US · IL NIH · grant
The Mentored Research Scientist Development Award (K01) will support my long-term career goal of testing whether the mental and physical health of youth, particularly those from communities with social and economic challenges, improves when…
Posted May 21, 2026
The role of sex chromosomes in neonatal hyperoxic lung injury
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY Bronchopulmonary dysplasia (BPD) is the most common complication affecting preterm neonates and is defined by supplemental oxygen dependence at 36 weeks postmenstrual age. Advances in neonatal care have improved overall surv…
Posted May 21, 2026
Control of biomolecular systems to guide cell phenotypes
US National Institute of General Medical Sciences · grant
Project Summary/Abstract Phenotype control, an active area of research in network control, is applicable to interacting biomolecular systems and can identify targeted interventions that lead to desired cell phenotypes. Phenotype control dis…
Posted May 21, 2026
Risk prediction methods
US National Cancer Institute · grant
We continued to develop, refine and evaluate the National Cancer Institute’s Breast Cancer Risk Assessment Tool (BCRAT). Dr. Mateo Banegas, a NCI Cancer Prevention Fellow, developed a new model for absolute invasive breast cancer risk for …
Posted May 21, 2026
Methods for Epidemiology Studies
US National Cancer Institute · grant
Extensions of likelihood-based sufficient dimension reduction methods were proposed and studied for analyzing biomarkers that are left and/or right censored due to lower or upper limits of detection. These methods apply generally to any typ…
Posted May 21, 2026
Biomarkers of Cognitive Decline Among Normal Individuals: The Biocard Cohort
US National Institute on Aging · grant
PROJECT SUMMARY/ABSTRACT This is an Administrative Supplement for the grant entitled ‘Biomarkers of Cognitive Decline Among Normal Individuals: The BIOCARD Cohort’. The BIOCARD study is a longitudinal study begun in 1995 to examine the prec…
Posted May 21, 2026
Core A: Administrative Core
US National Institute on Aging · grant
ADMINISTRATIVE CORE: CORE A - PROJECT SUMMARY/ ABSTRACT The Administrative Core (Core A) of the Johns Hopkins Alzheimer’s Disease Research Center (JHADRC) is central to the success of the Center, since it provides: (1) the overall direction…
Posted May 21, 2026
Research Training in Age-Related Cognitive Disorders
US National Institute on Aging · grant
This is an application for the third renewal of an institutional training grant in Age-Related Cognitive Disorders, first funded by NIA in 2007. The imperative to find better treatments for age-related cognitive disorders requires individua…
Posted May 21, 2026
Attentional Mechanisms of Cognitive Compensation in Subjective Cognitive Decline and AD Risk
US National Institute on Aging · grant
Attentional Mechanisms of Cognitive Compensation in Subjective Cognitive Decline and AD Risk Candidate: Dr. Kimberly Albert, PhD is an assistant professor in the Department of Psychiatry and Behavioral Sciences at the Vanderbilt University …
Posted May 21, 2026
Modeling Causal Effects of Components of Bundled Interventions with Application to a Multilevel Dental Caries Clinical Trial
US National Institute of Dental and Craniofacial Research · grant
This proposal seeks to develop new statistical methods applicable to studies of bundled interventions. Randomized clinical trials, including in dental research, often focus on multi-component and other complex interventions. Using such ‘bun…
Posted May 21, 2026