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Showing 25 / 20086 · page 131/804
Core A: Ultrastructural Assessment & Human Tissue
US National Heart Lung and Blood Institute · grant
SUMMARY/ABSTRACT – Scientific Core - Structure The goal of the Ultrastructural Assessment and Human Tissue Core is to maximize the scientific progress and productivity of the PPG investigators by providing essential services. The primary fu…
Posted May 21, 2026
Satellite Glial Cell Activation and Sympathetic Imbalance in Cardiomyopathy and Arrhythmias
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY/ABSTRACT Cardiac injury predisposes patients to heart failure (HF), and ventricular tachycardia/fibrillation (VT/VF). Development of HF and VT/VF after cardiac injury is tightly linked to sympathetic neural remodeling. Altho…
Posted May 21, 2026
Development of FES+BMI Neuroprosthesis for At-Home Use for Persons with Chronic Tetraplegia
US Veterans Affairs · grant
The current proposal aims to develop a for at-home-use neuroprosthesis for restoring brain-controlled functional hand grasping to Veterans and others living with chronic tetraplegia due to spinal cord injury (SCI). This system leverages and…
Posted May 21, 2026
BCM/TSU P20 Collaborative Union for Cancer Research and Educational Development (BCM-TSU P20 CURED) Administrative Core (AC)
US National Cancer Institute · grant
ABSTRACT – CURED Administrative Core Administrative Core of the proposed BCM-TSU P20 CURED program will serve as a primary administrative unit that oversees the collaborative research, education and associated outreach efforts between the …
Posted May 21, 2026
Community Engagement Core
US National Institute on Minority Health and Health Disparities · grant
ABSTRACT: Community Engagement Core (CEC) Texas Southern University (TSU) has a long history of community trust and thus unparalleled ability to implement innovative community engagement/outreach efforts to address health-related concerns …
Posted May 21, 2026
Investigating the origin and functional properties of immune cells in noise-induced hearing loss
US National Institute on Deafness and Other Communication Disorders · grant
PROJECT SUMMARY/ABSTRACT In this proposed work, we seek to understand the cellular identity of macrophages, the main immune cells in the cochlea, in noise-induced hearing loss (NIHL). Our previous studies have shown that macrophages in the …
Posted May 21, 2026
Mechanism of alpha5 integrin contribution to Amyotrophic Lateral Sclerosis pathology.
US National Institute of Neurological Disorders and Stroke · grant
Project Summary/Abstract Amyotrophic Lateral Sclerosis (ALS) is the third most common neurodegenerative disease, with no cure and limited treatment options. While motor neurons are primarily affected, non-neuronal cells, particularly myeloi…
Posted May 21, 2026
Functional Magnetic Resonance Imaging and Deep Learning to Improve Deep Brain Stimulation Therapy
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY/ABSTRACT Successful treatment of Parkinson's disease (PD) using deep brain stimulation (DBS) therapy requires an optimal setting of stimulation parameters to correct brain function anomalies. The commonly employed DBS 1.0 el…
Posted May 21, 2026
Appetite regulation with DTG based ART in postpartum women living with HIV and their infants (Ar-DART)
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Project Summary Weight gain with Dolutegravir (DTG), an integrase strand transfer inhibitor (INSTI), has been observed in People living with HIV (PLHIV) including postpartum women. How DTG-based ART regimens affect postpartum weight is not…
Posted May 21, 2026
Advanced Research Institute (ARI) in Mental Health and Aging
US National Institute of Mental Health · grant
The overarching goal of the "Advanced Research Institute (ARI) in Mental Health and Aging” is to increase the number of early-career faculty successfully transitioning to independent investigators conducting high impact research in mental h…
Posted May 21, 2026
Clinical and Translational Research Training in Geriatric Mental Health
US National Institute of Mental Health · grant
This proposal requests support for the five-year continuation of our NIMH-funded institutional training grant, “Clinical and Translational Research Training in Late-Life Mood Disorders” (T32 MH019986), Years 26-30. The primary goal of this…
Posted May 21, 2026
Roles of Gray Matter Brain Aging and Small Vessel Disease in AD Pathophysiology
US National Institute on Aging · grant
In this Yr16 renewal of our longitudinal study on the natural progression of AD biomarkers, the central goal remains to further understand the occurrence of asymptomatic amyloid-beta (Aβ) and tau deposition and the progression to clinical c…
Posted May 21, 2026
Research Education Component
US National Institute on Aging · grant
Recruitment and Education Component (REC): Abstract: The primary goal of the Research Education Component (REC) is to identify, attract, and promote the career development of ADRD investigators. The PITTADRC REC assumes primary responsibil…
Posted May 21, 2026
Imaging brain fluid dynamics in relation to reactive astrogliosis and cerebral amyloid accumulation
US National Institute on Aging · grant
Project 3 Abstract Intriguing evidence implicates reactive astrogliosis as impairing brain fluid dynamics (BFD) via multiple mechanisms, including 1) altering expression of the aquaporin-4 (AQP-4) water channel along the astrocytic end feet…
Posted May 21, 2026
Brown University Postbaccalaureate Research Education Program
US National Institute of General Medical Sciences · grant
This proposal seeks continued support for the Postbaccalaureate program at Brown University (renamed ‘PREP@Brown) to advance our work in developing a highly-talented pool of knowledgeable and well-trained individuals who go on to pursue Ph.…
Posted May 21, 2026
Implementation of Confidential Care to Increase Adolescent HIV Testing in Pediatric Primary Care Settings
US National Institute of Mental Health · grant
PROJECT SUMMARY/ABSTRACT In the United States, adolescents are the age group least likely to be aware of their HIV infection and linked to care in a timely manner, contributing to disproportionately low rates of viral suppression and increa…
Posted May 21, 2026
Binding specificity and transcriptional regulation of antigen I/II adhesins in Streptococcus gordonii
US National Institute of Dental and Craniofacial Research · grant
Project Summary/Abstract Bacterial expression of cell surface-associated adhesin proteins facilitates the formation of biofilms. Dental plaque is a polymicrobial biofilm of the human mouth that contributes to oral infectious diseases. Forma…
Posted May 21, 2026
CORE FUNCTION ACTIVITIES TASK ORDER TO PROVIDE EXPERT PI PROTOCOL REVIEWS, AD-HOC CONSULTATION, QUERY RESOLUTION AND OVERALL SITE-SPECIFIC MANAGEMENT AND PREPAREDNESS TO CONDUCT NEW STUDIES UNDER THE
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
The purpose of this Task Order entitled “Core Function Activities” is to provide needed expert PI protocol reviews in developing new clinical studies under the Network, ad-hoc consultation as issues arise pertaining Alcohol Use Disorder res…
Posted May 21, 2026
Alzheimer's Clinical Trials Consortium (ACTC)
US National Institute on Aging · grant
This is a multi-PI application renewing the U24 Cooperative Agreement to sustain and expand the NIA’s state-of-the-art Alzheimer Clinical Trial Consortium (ACTC) responsible for conducting academic clinical trials across the continuum of Al…
Posted May 21, 2026
Structure and regulation of lipid metabolism and transport
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY: We are interested in understanding how lipid-metabolizing enzymes and lipid transport proteins function and are regulated at the molecular and structural level. Previously, we focused on two enzymes in phosphatidic acid (PA…
Posted May 21, 2026
Metabolic and epigenetic reprogramming in cyclin E high ovarian cancer
US National Cancer Institute · grant
Project Summary/Abstract The ultimate goal of this mPI proposal is to address a fundamental gap in knowledge on the role of acetyl-CoA metabolic reprogramming in regulating cyclin E-high ovarian cancer DNA damage response, transformation, a…
Posted May 21, 2026
Investigating p16 Loss in Pro-tumorigenic Metabolism
US National Cancer Institute · grant
Project Summary/Abstract The ultimate goal of this proposal is to address a fundamental gap in knowledge on the role of the cell cycle inhibitor p16 in regulating pro-tumorigenic metabolism. The results from these studies could have a signi…
Posted May 21, 2026
Acylcarnitine Metabolism in Ovarian Cancer Chemoresistance
US National Cancer Institute · grant
PROJECT SUMMARY ABSTRACT High-grade serous ovarian carcinoma (HGSOC) is the most prevalent histosubtype of epithelial ovarian cancer. Therapy for HGSOC relies on DNA damaging agents, with a high percentage of cancers having de novo or acqui…
Posted May 21, 2026
Cell intrinsic and extrinsic effects of zinc metabolism in therapy resistant melanoma
US National Cancer Institute · grant
Project Summary/Abstract The ultimate goal of this proposal is to address the fundamental gap in knowledge on the mechanisms driving resistance to immune checkpoint blockade (ICB), particularly in melanoma patients who exhibit downregulatio…
Posted May 21, 2026
Clinical Translation of Ultrasonic Ketamine Uncaging for Non-Opioid Therapy of Chronic Pain
US National Institute of Neurological Disorders and Stroke · grant
Narcotic use in chronic pain treatment has played a major role in the ongoing opioid crisis. Convergent evidence indicates that the activity of the anterior cingulate cortex (ACC) is critical in the pathophysiology of chronic pain. Local th…
Posted May 21, 2026