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Showing 25 / 20086 · page 132/804
Molecular pathogenesis of COVID-19-associated coagulopathy and new therapeutic approaches
US National Heart Lung and Blood Institute · grant
Project Summary Many studies have highlighted a large incidence of hemostatic derangements in the form of hypercoagulable and hypofibrinolytic states following SARS-CoV-2 infection. These hemostatic disturbances are fueled by and a conseque…
Posted May 21, 2026
Tunable Temporal Drug Release for Optimized Synergistic Combination Therapy of Glioblastoma
US National Cancer Institute · grant
ABSTRACT Glioblastoma’s (GBM) invasive nature is part of the reason this primary brain tumor results in near 100% mortality. Even with surgical resection, radiation, and chemotherapy, the median survival remains of only 12-15 months. Tumor …
Posted May 21, 2026
Mechanistic evaluation of mast cell agonists combined with TLR, NOD and STING agonists.
US National Institute of Allergy and Infectious Diseases · grant
ABSTRACT Subunit vaccines are safer and can more broadly be applied across the population then other vaccine formulations such as live-attenuated. However, subunit antigens are often poorly antigenic and require formulation with an immune s…
Posted May 21, 2026
Biomaterial-Enhanced CAR-T/NK Cell Therapies for Glioblastoma.
US National Cancer Institute · grant
ABSTRACT This comprehensive research program is focused on revolutionizing the treatment of Glioblastoma (GBM), a highly aggressive brain tumor that currently has limited and largely ineffective treatment options. GBM is known for its devas…
Posted May 21, 2026
Biodegradable polymeric microparticles comprised of acetalated dextran induce immune tolerance
US National Institute of Allergy and Infectious Diseases · grant
ABSTRACT The clinical treatment of autoimmune diseases traditionally uses immunosuppression to curtail the pathogenesis of the autoimmune disease. An alternative for general immune suppression, is antigen specific tolerance. However, there …
Posted May 21, 2026
Network on Life Course Health Dynamics and Disparities in 21st Century America Renewal
US National Institute on Aging · grant
Most measures of adult health and longevity in the United States lag well behind those of other wealthy countries. Despite widening recognition of this crisis, we have only a limited understanding of its causes and few strategies to reverse…
Posted May 21, 2026
Multidisciplinary Research Training in Gerontology
US National Institute on Aging · grant
Abstract The USC Multidisciplinary Research Training Program in Gerontology provides predoctoral and postdoctoral training using a multidisciplinary approach that considers aging from all levels, including cellular, brain systems, psycholog…
Posted May 21, 2026
Core C - Communication and Dissemination Core
US National Institute on Aging · grant
REVISED ABSTRACT – CORE C: COMMUNICATION AND DISSEMINATION CORE (CDC) The Communication and Dissemination Core (CDC) advances the mission of the USC/UCLA Center on Biodemography and Population Health (CBPH) by enhancing the visibility, rea…
Posted May 21, 2026
Chemistry Services for the National Toxicology Program-Per and polyfluorinated substances (PFAS)
US National Institute of Environmental Health Sciences · grant
The goal of this project is to provide chemistry-based services to support the division of translational toxicology (DTT) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmenta…
Posted May 21, 2026
Chemistry Services for the National Toxicology Program- Botanicals and Dietary Supplements and mixtures
US National Institute of Environmental Health Sciences · grant
The goal of this project is to provide chemistry-based services to support the division of translational toxicology (DTT) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmenta…
Posted May 21, 2026
Chemistry Services for the National Toxicology Program-Disperse Dyes
US National Institute of Environmental Health Sciences · grant
The goal of this project is to provide chemistry-based services to support the division of translational toxicology (DTT) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmenta…
Posted May 21, 2026
Chemistry Services for the National Toxicology Program -High Throughput Toxicological Screening Support
US National Institute of Environmental Health Sciences · grant
TThe goal of this project is to provide chemistry-based services to support the division of translational toxicology (DTT) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environment…
Posted May 21, 2026
Chemistry services for the National Toxicology Program-General Chemistry Support
US National Institute of Environmental Health Sciences · grant
The goal of this project is to provide chemistry-based services to support the division of translational toxicology (DTT) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmenta…
Posted May 21, 2026
End Diagnostic Overshadowing: Addressing Ableism in the Healthcare Context
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Through our End Diagnostic Overshadowing: Addressing manifestations of ableism in the healthcare context program we aim to identify and create understanding of mechanisms underlying diagnostic overshadowing and mitigate and reduce its effec…
Posted May 21, 2026
Investigating the Role of Slc4a4 in Multiple Sclerosis
US National Institute of Neurological Disorders and Stroke · grant
ABSTRACT Multiple Sclerosis (MS) is one of the most common autoimmune diseases affecting the central nervous system, impacting approximately 2.5 million people worldwide. It is characterized by immune cell-driven inflammatory demyelination …
Posted May 21, 2026
HIV Virology Core
US National Institute of Allergy and Infectious Diseases · grant
HIV Virology Core To support the needs of the three PCHPI projects, recipients of Collaborative Development Awards, and external collaborative projects, we will establish an HIV Virology Core (HVC). The primary missons of the HVC will be to…
Posted May 21, 2026
Nef in impaired efferocytosis: a novel mechanism for vascular disease in HIV
US · IL National Institutes of Health (NIH) · NAICS 541711 · $unknown · grant
Project Summary Anti-retroviral therapy (ART) has protected many HIV patients against the development of AIDS. HIV infection has become a treatable disease. Increased risk for atherosclerotic vascular diseases in long-term HIV survivors or …
Posted May 21, 2026
PROJECT 1 – STRUCTURAL BIOLOGY OF DNA DEAMINASES IN CANCER
US National Cancer Institute · grant
PROJECT 1 – STRUCTURAL BIOLOGY OF DNA DEAMINASES IN CANCER ABSTRACT The human APOBEC3 (A3) family of deaminases catalyze the conversion of cytosine to uracil in single- stranded DNA to elicit mutations and genome instability, which in turn…
Posted May 21, 2026
Structural studies of viral replication and invasion
US National Institute of General Medical Sciences · grant
Abstract Viruses are a major threat to human health. Our laboratory uses various structural biology techniques to dissect molecular mechanisms of how viruses replicate and invade the host cell or its genome. One area of our major interest i…
Posted May 21, 2026
The role of inflammation in the regulation of immune response in acute myeloid leukemia
US National Cancer Institute · grant
Project Summary/Abstract Survival outcomes of acute myeloid leukemia (AML) patients are negatively affected by high inflammation in the bone marrow compared to low inflammation patients within the same molecular subgroup. The overarching go…
Posted May 21, 2026
Mapping and targeting 3D regulatory elements in leukemia and lymphoma-Supplement
US National Cancer Institute · grant
Project Summary/Abstract (underlined are the added text and data related to this administrative supplement) Despite cancer being typically depicted as a genetic disease, aberrations in epigenetic regulation and gene expression play a determ…
Posted May 21, 2026
Oncogenic triggers and their influence on 3D chromosomal architecture
US National Cancer Institute · grant
PROJECT 3: PROJECT SUMMARY Recent studies connected 3D nuclear and chromosomal architecture to the regulation of gene expression in multiple tissues and cell types. PIs in this Program Project were some of the first to link 3D topology to c…
Posted May 21, 2026
Mapping and targeting 3D regulatory elements in leukemia and lymphoma
US National Cancer Institute · grant
PROJECT SUMMARY/ABSTRACT Despite cancer being typically depicted as a genetic disease, aberrations in epigenetics and gene expression play a determinant role in transformation and response to therapies. Derailed from their developmental pat…
Posted May 21, 2026
mRNA stability and its impact on hematopoiesis and acute leukemia
US National Cancer Institute · grant
Abstract This application focuses on acute myeloid leukemia (AML), a blood cancer that is characterized by low survival rates and few available targeted therapies. The five-year overall survival rate for AML is below 30 percent in adults an…
Posted May 21, 2026
LeveRaging Community Engagement to SusTAIN NCD InTegrated Care Models (RETAIN-IT)
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY The increased life expectancy of people living with HIV/AIDS (PLWH) and the associated burden of non- communicable diseases (NCDs) in PLWH has prompted an urgent need for effective community engaged strategies that engage ca…
Posted May 21, 2026