Live opportunities

20,086 contracts

🏛Federal 🗽State 🏞County 🏙City 🎓Schools 🚇Districts 📚Universities
Showing 25 / 20086 · page 60/804
Perfluoroalkyl Substances and the Gut Microbiome and Fecal Metabolome: Implications for Obesity Risk in Hispanic Children
US · IL NIH · grant
ABSTRACT Childhood obesity is a high priority public health issue as it increases the risk of co-morbid diseases, including cardiovascular disease, fatty liver disease, and type 2 diabetes. An improved understanding of the factors that trig…
Posted May 21, 2026
Mechanisms of Telomere-Mediated Lung Disease
US National Heart Lung and Blood Institute · grant
Abstract Telomere dysfunction has emerged as a primary contributor to diseases within the human lung. Over the past five years, our group has shown that telomere dysfunction limits the proliferative capacity of lung epithelial cells and ren…
Posted May 21, 2026
SASP-ER platform to identify spatiotemporal senescence-associated secretome
US National Institute on Aging · grant
PROJECT SUMMARY The goal of this R21 project is to build a research platform to assess senescence-associated secretory phenotype (SASP) in vivo. A prominent feature of cellular senescence is the secretion of diverse biologic factors (cytoki…
Posted May 21, 2026
Genomic Biomarkers of Cancer
US National Cancer Institute · grant
We have made substantial progress on goal #3, where we have submitted a paper to Lancet Oncology, showing that molecular genomic alterations can be predicted from histopathology in CNS tumors. Our model integrates three distinct components:…
Posted May 21, 2026
Single-cell DNA methylation analysis of human cancer
US National Cancer Institute · grant
We have used techniques in machine learning and deconvolution of methylation data to elucidate genomic profiles of several CNS cancers. Recent advances in artificial intelligence (AI) and computer vision empower deep learning models to infe…
Posted May 21, 2026
Development and validation of a predictor of meningioma recurrence
US National Cancer Institute · grant
Meningiomas exhibit considerable clinical and biological heterogeneity. We previously identified 4 distinct molecular groups (immunogenic, NF2-wildtype, hypermetabolic, and proliferative) that address much of this heterogeneity. Despite the…
Posted May 21, 2026
Cognitive Behavioral Therapy for Treatment-Seeking to Improve Treatment Engagement and Reduce Suicide Risk Among Deaf Individuals
US National Institute of Mental Health · grant
ABSTRACT Deaf individuals are one of the most understudied and underserved cultural populations in the field of mental health. While limited, data suggests significant mental health disparities among Deaf adults including higher rates of su…
Posted May 21, 2026
Uncovering latent factors underlying weak and robust responses to influenza vaccine in healthy and obese older adults
US National Institute of Allergy and Infectious Diseases · grant
Summary/Abstract Although vaccination is the most effective measure for influenza prevention, there is considerable variation in the responses to influenza vaccines that is influenced by factors such as age, sex, and obesity level. Major ad…
Posted May 21, 2026
The Role of Staphylococcus aureus SasD in Lung
US National Heart Lung and Blood Institute · grant
SUMMARY Despite intense research focus, Staphylococcus aureus has remained an important cause of both community acquired pneumonia and viral-related super-infections. The field has recently determined host mediated mechanisms induced by S. …
Posted May 21, 2026
Dissecting how gene regulatory redundancy ensures robustness of mammalian development
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
PROJECT SUMMMARY/ABSTRACT Transcriptional enhancers are non-coding DNA elements that control the expression of their target genes with spatiotemporal specificity. Transcription factors confer the specificity of enhancer function by recruiti…
Posted May 21, 2026
Neurocognitive Outcomes and the Trajectory of Recovery One-year After Pediatric Sepsis
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
PROJECT SUMMARY Acute brain dysfunction (ABD) during sepsis occurs in 30% of children and is associated with a seven-fold increased risk of mortality. Survivors who experienced ABD during sepsis are more likely to have both functional morbi…
Posted May 21, 2026
Clinical Sciences Core
US National Institute of Allergy and Infectious Diseases · grant
Modified Project Summary/Abstract Section Clinical The CFAR Clinical Sciences Core (Core C) provides unique clinical resources and scientific leadership for the largest network of HIV investigators in South Florida and promotes high impact…
Posted May 21, 2026
MACS/WIHS -CCS
US · FL · Miami NIH · grant
ABSTRACT Nearly half the men and women with HIV infection are racial/ethnic minorities living in the South. HIV infection remains a major public health problem despite the availability of treatments. The purpose of this proposal is to advan…
Posted May 21, 2026
SCIENTIFIC ADMINISTRATIVE CORE (SAC)
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
ABSTRACT – Scientific Administrative Core (SAC) Despite advancements in HIV prevention, treatment, and care in the context of modern antiretroviral therapy (ART), reproductive age women are uniquely affected by HIV yet remain under-represe…
Posted May 21, 2026
Regulation of T cell immune response in Heart Failure with Preserved Ejection Fraction
US National Heart Lung and Blood Institute · grant
The goal of this R01 application is to investigate the mechanisms by which T cells contribute to heart failure (HF) with preserved ejection fraction (HFpEF), affecting roughly 50% of the HF patients. Notably, the treatments that improve sur…
Posted May 21, 2026
Rapid and economical system for preparation of PFAS samples to lower the Method Detection Limit
US National Institute of Environmental Health Sciences · grant
Project Abstract This project aims to develop an innovative and cost-effective PFAS sample preparation (C- PREP) system that signiflcantly lowers the Method Detection Limit (MDL) and enhances high-throughput capabilities. Utilizing InnovaPr…
Posted May 21, 2026
Arthroscopic Raman Monitoring of Cartilage Content for PTOA Diagnosis and Chondroregenerative Treatment Response
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Arthroscopic Raman Monitoring of Cartilage Content for PTOA Diagnosis and Chondroregenerative Treatment Response PTOA is a common, incapacitating, chronic condition among individuals who sustain traumatic joint injuries. Currently, even aft…
Posted May 21, 2026
A Bio-inspired Latent TGF-beta Conjugated Scaffold for Patient-specific Cartilage Regeneration
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Summary Transforming growth factor beta (TGF-) has become one of the most widely utilized mediators to promote cartilage growth in tissue engineering (TE) applications. Conventionally, for in vitro culture phases, TGF- is supplemented in …
Posted May 21, 2026
Sphingomyelin Metabolism Impacts on Crystalline Silica-Induced Outcomes
US National Institute of Allergy and Infectious Diseases · grant
Abstract There are numerous examples of endogenous and exogenous particle-induced chronic inflammation. One model of chronic environmentally-induced inflammation is driven by exposure to crystalline silica particles. There are various occup…
Posted May 21, 2026
Supplement For Continuity Through Major Life Event
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY Cells are the building blocks that comprise and pattern multicellular organisms from plants to humans, and many types of cells themselves exhibit complex shapes and patterns. While we understand many of the molecular compone…
Posted May 21, 2026
RNA and genome regionalization in giant single cells: implications for cellular patterning
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY Cells are the building blocks that comprise and pattern multicellular organisms from plants to humans, and many types of cells themselves exhibit complex shapes and patterns. While we understand many of the molecular compone…
Posted May 21, 2026
Deciphering Novel Principles of Rapid Proteostatic Control and Innovating Spatiotemporal Lysosomal Tools
US National Institute of General Medical Sciences · grant
PROJECT ABSTRACT Proteome integrity is maintained by a complex network that regulates protein synthesis, folding, transport, and degradation. Lysosomes are the catabolic center of a cell and central to maintaining proteome homeostasis by pr…
Posted May 21, 2026
Recovery among Older Adults Following Head Injury
US National Institute on Aging · grant
Development of Alzheimer's disease and related dementias (ADRD) is multifactorial, and some causal factors can be influenced or modified. Recently, the Lancet Commission included traumatic brain injury (TBI) in its list of 12 key potentiall…
Posted May 21, 2026
CLINTRUSC Community Engagement & Outreach Core
US National Institute of General Medical Sciences · grant
CEO-Project Summary The overarching goal of the Clinical Engagement and Outreach (CEO) Core will be to provide a unified network of clinical sites throughout the South Carolina Midlands in which clinical and translational research can be pe…
Posted May 21, 2026
Elucidating the Role of the Hippocampus in Motor Memory using Temporal Interference Stimulation
US National Institute of Mental Health · grant
Project Summary/Abstract The hippocampus was long described by seminal memory models to not be necessary for procedural (motor) learning. In contrast, neuroimaging studies from the last two decades consistently show hippocampal recruitment …
Posted May 21, 2026