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Showing 25 / 20086 · page 130/804
Study the role of ICOS on murine and human ILC2s
US National Institute of Allergy and Infectious Diseases · grant
SUMMARY The long-term goal of this study is to increase our understanding of the immune mechanisms involved in the pathogenesis of allergic diseases and asthma. Allergic asthma is a chronic inflammatory disorder that is characterized by air…
Posted May 21, 2026
Transcriptional and metabolomic regulation of IL-10 in pulmonary ILC2s
US National Institute of Allergy and Infectious Diseases · grant
Abstract ILC2s are the dominant innate lymphoid cell population in the lungs at steady state and their release of type-2 cytokines is a central driver in responding eosinophil infiltration, increased airway hyperreactivity and associated lu…
Posted May 21, 2026
Role of TNF receptor 2 on Pulmonary Group 2 Innate Lymphoid Cells
US National Heart Lung and Blood Institute · grant
Abstract The long-term goal of this project is to develop better therapies for respiratory inflammation and allergic asthma. Group 2 innate lymphoid cells (ILC2) are a recently identified cell population producing type 2 cytokines in respon…
Posted May 21, 2026
MitoPac female killing systems in mosquitoes
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY Dengue, chikungunya, and Zika are diseases transmitted by Aedes aegypti. One strategy to reduce Ae. aegypti populations is to release non-biting male mosquitoes that pass female killing genes to their progeny. Over time and…
Posted May 21, 2026
Conditional and female lethal approaches for mosquito control
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY Gene drives (GDs) are a cutting-edge technology with the potential to improve human health, but gene drives have many limitations that impede their useful application in the wild, particularly population suppression drives.…
Posted May 21, 2026
Host-pathogen interactions during GBS diabetic wound infections
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY Group B Streptococcus (GBS), is a Gram-positive pathobiont that commonly colonizes the gastrointestinal and lower female reproductive tracts but can cause adverse health outcomes in neonates and vulnerable adult populations.…
Posted May 21, 2026
VCU Initiative for Maximizing Student Development Program (IMSD)
US National Institute of General Medical Sciences · grant
Project Summary The VCU Initiative for Maximizing Student Development (IMSD) program has had an outstanding record of educating underrepresented scholars in biomedical research since its inception in 2010. The IMSD program previously suppor…
Posted May 21, 2026
Gastrointestinal Dysfunction in Down Syndrome
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
PROJECT SUMMARY Down syndrome (DS), or Trisomy 21, is the most frequent chromosomal abnormality in humans, resulting from a complete or partial extra copy of chromosome 21. Clinically, DS is identified after birth through the recognition of…
Posted May 21, 2026
A Genome Data Analysis Center Focused on Batch Effect Analysis and Data Integration
US National Cancer Institute · grant
* * * * PROJECT SUMMARY * * * * Abstract: Technical batch effects pose a fundamental challenge to quality control and reproducibility of even single-laboratory research projects, but the possibilities for serious error are greatly magnified…
Posted May 21, 2026
Laboratory & Biobehavioral Marker Core E
US National Institute of Mental Health · grant
ABSTRACT Consistent with the Center’s theme, the mission of Core E is to facilitate a broad range of biological and behavioral intervention studies that are designed to optimize psychiatric, behavioral, and medical outcomes among persons wi…
Posted May 21, 2026
Neurovascular Interactions: Mechanisms, Imaging, Therapeutics
US National Institute of Neurological Disorders and Stroke · grant
The neurovascular interface fundamentally changes during CNS diseases due to increased blood-brain barrier permeability and influx of plasma proteins in the CNS parenchyma. Studying neurologic diseases through the multidisciplinary prism of…
Posted May 21, 2026
OPC-X screen: Discovery of small molecule inhibitors to overcome extrinsic inhibition of remyelination.
US National Institute of Neurological Disorders and Stroke · grant
Project Summary/Abstract Multiple Sclerosis (MS) is a chronic inflammatory, neurodegenerative disease involving the destruction of myelin sheaths on neurons resulting in axonal damage leading to permanent functional deficits including paral…
Posted May 21, 2026
Hormone-Free Prebiotic Muco-Adhesive Gels To Treat Vaginal Atrophy in Post-Menopausal Women
US National Institute on Aging · grant
PROJECT ABSTRACT/SUMMARY Vaginal Atrophy (VA), a component of Genitourinary Syndrome of Menopause, is a chronic and progressive condition that affects approximately 50% of post-menopausal women due to estrogen deficiency. Without treatment,…
Posted May 21, 2026
Intimate Partner Violence and Depression Trajectories from mid-Adolescence to Young Adulthood
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
PROJECT SUMMARY Intimate partner violence (IPV) and depression are substantial public health challenges for U.S. adolescents, and evidence suggests a clear link between IPV experiences and subsequent depression. Despite their co- occurrence…
Posted May 21, 2026
Molecular and biophysical mechanism of plasma membrane internalization during nonclathrin endocytosis
US National Institute of General Medical Sciences · grant
During endocytosis, the cell's plasma membrane is deformed and internalized to bring in extracellular cargo and transmembrane receptors. Nonclathrin/noncaveolar (CLIC/GEEC) endocytosis internalizes glycosylated receptors and extracellular f…
Posted May 21, 2026
Multifunctional Nanotechnology Platform for Triple Negative Breast Cancer Treatment
US National Institute of General Medical Sciences · grant
Project Summary: Triple-negative breast cancer (TNBC) accounts for approximately 15% of invasive breast cancers and is associated with aggressive tumor biology, poor prognosis, resistance, visceral metastases and earlier disease recurrence.…
Posted May 21, 2026
Pilot Project #1
US National Cancer Institute · grant
Project Summary/Abstract Prostate cancer is a leading cause of cancer-related death in men. Novel technologies can improve access to high-quality care—particularly for patients at increased risk of aggressive disease or living in areas wit…
Posted May 21, 2026
The roles of Rett Syndrome protein MECP2 at gene regulatory elements
US National Institute of Mental Health · grant
Project Summary: Rett Syndrome (RTT) is a progressive neurological disorder characterized by severe cognitive and motor impairments caused primarily by mutations in MECP2. The molecular mechanisms by which disruption of MECP2 gives rise to …
Posted May 21, 2026
Regulation and function of DNMT3A-mediated methylation in the brain.
US National Institute of Mental Health · grant
Project Summary: The DNA methyltransferase DNMT3A is mutated in individuals with neurological disorders such as autism and intellectual disabilities. DNMT3A is highly expressed in the nervous system, primarily methylating atypical non- CG s…
Posted May 21, 2026
Medical Scientist Training Program
US National Institute of General Medical Sciences · grant
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. The mission of the Albert Einstein College of Medicine Medical Scientist Training Program (MSTP) is to trai…
Posted May 21, 2026
MI Center for Contextual Factors in Alzheimer's Disease (MCCFAD) Yrs 6-10
US National Institute on Aging · grant
The Michigan Center for Contextual Factors in Alzheimer’s Disease (MCCFAD) aims to foster and enhance innovative research in Alzheimer’s disease and related dementias (ADRD) with the long term goals to 1) advance ADRD-relevant social and be…
Posted May 21, 2026
Changing the Landscape of Soil Transmitted Helminth Infections in India Using a One Health Approach
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY Soil transmitted helminths (STH) - hookworms (Ancylostoma duodenale and Necator americanus), Ascaris lumbricoides and Trichuris trichiura - are among the most widespread neglected tropical diseases (NTD) of humans worldwide…
Posted May 21, 2026
Small extracellular vesicles mediated signaling and pain
US National Institute of Neurological Disorders and Stroke · grant
Abstract Chronic pain is the most prevalent, disabling, and expensive public health condition in the United States. The goal of this project is to elucidate how to harness body’s own analgesic mechanisms to provide pain relief. We propose t…
Posted May 21, 2026
Immune modulating therapies to treat complex regional pain syndrome
US National Institute of Neurological Disorders and Stroke · grant
Abstract Complex regional pain syndrome (CRPS) is a chronic pain disorder of unknown etiology that can affect one or more extremities. Difficulty in treating CRPS stems from incomplete understanding of the underlying mechanisms. Despite dif…
Posted May 21, 2026
Passive cognitive assessment across the menopausal transition
US National Institute on Aging · grant
PROJECT SUMMARY Menopause is a traditionally underappreciated and undertreated condition that affects approximately 1 billion women worldwide. Half of those women also have significant symptoms associated with the menopausal transition, inc…
Posted May 21, 2026