Live opportunities

20,086 contracts

🏛Federal 🗽State 🏞County 🏙City 🎓Schools 🚇Districts 📚Universities
Showing 25 / 20086 · page 135/804
Cell Type Specific Transcriptional Cascades in Inner Ear Development
US National Institute on Deafness and Other Communication Disorders · grant
Disabling age-related hearing loss (ARHL) afflicts greater than 50% of the population over the age of 70. The progressive loss of sensory hair cells (HCs) of the cochlea, primarily the outer HCs (OHCs), is either the cause or the final comm…
Posted May 21, 2026
Usher Proteins in the Inner ear Structure and Function
US National Institute on Deafness and Other Communication Disorders · grant
Hearing loss (HL) is an etiologically diverse condition that can occur at any age and severity level, affecting 1 in 500 infants and more than 360 million people globally1; 2. In numerous ethnicities, we have previously identified pathogeni…
Posted May 21, 2026
Genetic and Molecular Dissection of Wnt Pathway Activation
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY Tissue specification, growth, maintenance, and regeneration rely on spatiotemporal cues provided by the evolutionarily conserved Wnt morphogen pathway. Many developmental disorders and cancers, including nearly all colorecta…
Posted May 21, 2026
A Cereblon signaling network in Wnt-driven cancers
US National Cancer Institute · grant
A Cereblon Signaling Network in Wnt-driven Cancers Abstract The long-term objective of this study is to investigate how Cereblon (CRBN) regulates the Wnt signal transduction pathway and to demonstrate how this can be exploited to target Wnt…
Posted May 21, 2026
Telomere uncapping epigenetically reprograms a stress response and longevity pathway
US National Institute of Environmental Health Sciences · grant
Summary Interstitial Telomere Sequences (ITS tracts) are degenerate telomere repeat tracts found on metazoan chromosome arms whose functional significance is not known. We propose to develop a new paradigm in the field of telomere biology,…
Posted May 21, 2026
Role of Fn-14 receptor in TNF-induced inflammation and tissue destruction
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY Tumor necrosis factor (TNF)-α is a major inflammatory cytokine involved in the pathogenesis of several autoimmune and inflammatory diseases, including rheumatoid arthritis (RA). Current approaches aim to curb TNF-α-induced i…
Posted May 21, 2026
Molecular mechanisms of TAK1 regulation in rheumatoid arthritis
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
PROJECT SUMMARY In rheumatoid arthritis (RA), activated synovial fibroblasts (SFs) transform into an invasive phenotype that recruits immune cells to cause tissue destruction. Recent findings show transforming growth factor β-activated kina…
Posted May 21, 2026
VS4A: VITAL Start (Video-Intervention to Inspire Treatment Adherence for Life) for Adolescents, a video intervention to improve retention and adherence to ART among adolescents living with HIV
US National Institute on Minority Health and Health Disparities · grant
PROJECT SUMMARY/ABSTRACT The 1.7 million adolescents living with HIV (ALHIV) globally urgently need interventions to help improve retention, adherence, and ultimately viral load suppression (VLS). With both high rates of incident infection …
Posted May 21, 2026
Summer Veterinary Student Research (SVSRP)
US NIH Office of the Director · grant
Veterinary students are particularly qualified in comparative medicine, a training that is an invaluable resource in animal model research. However, most students do not pursue research careers because of a lack of exposure to biomedical re…
Posted May 21, 2026
T Cell Memory to Viruses
US National Institute of Allergy and Infectious Diseases · grant
Chronic viral infections are characterized by a state of T cell dysfunction that is associated with expression of the PD-1 (programmed cell death 1) inhibitory receptor. A better understanding of the mechanisms that regulate CD8 T cell resp…
Posted May 21, 2026
Vaccine and Infection Induced Immunity in the Young and Aged
US National Institute of Allergy and Infectious Diseases · grant
The overarching goal of our CCHI application on “Vaccine and Infection Induced Immunity in the Young and Aged” is to address fundamental issues about innate and adaptive immunity in humans to infection and vaccination. Our proposal is focus…
Posted May 21, 2026
Udall Catalyst Research Project: Retrosplenial Cholinergic and Attentional-Motor Integration Dysfunction
US National Institute of Neurological Disorders and Stroke · grant
CATALYST RESEARCH PROJECT: SUMMARY/ABSTRACT Many patients with Parkinson’s disease (PD) suffer from spatial disorientation – inability to link external landmark cues to internal estimates of self-orientation. These deficits are not improved…
Posted May 21, 2026
Circuit Mechanisms of Psilocybin Following Chronic Stress
US National Institute of Mental Health · grant
ABSTRACT / PROJECT SUMMARY Chronic stress is thought to play a role in multiple neuropsychiatric disorders. Standard pharmacological treatments for stress-related disorders can take up to several months to elicit a therapeutic response and…
Posted May 21, 2026
Community-Engaged Approach to Supporting South Asians w/ Type 2 Diabetes at Risk for Depression
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Community-Engaged Approach to Supporting Patients with Type 2 Diabetes at Risk for Depression Background: Patients with Type 2 diabetes (T2D) are at increased risk for depression (60%), and patients with depression have a 32% increased ris…
Posted May 21, 2026
Role of Lung Repair and Regeneration Pathways in Tuberculosis
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis (Mtb), infects one-fourth of the world’s population. Majority of the infected individuals are latently infected (LTBI), of which 5-10% stand …
Posted May 21, 2026
Metabolic regulation of Neutrophil Extracellular Traps (NETs) in TBI
US National Institute of Neurological Disorders and Stroke · grant
Abstract: Traumatic brain injury (TBI) is a significant global public health issue, leading to high mortality rates, disabilities, and substantial socioeconomic burdens. TBI results in the loss of AMPKα activity, disruption in regional meta…
Posted May 21, 2026
Identification of novel lead EphB1/2 tyrosine kinase inhibitors targeting peripheral neuropathic pain
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY/ ABSTRACT. Chronic pain is a common debilitating condition that often leads to the prescription of escalating opioid doses and has created a nationwide severe crisis. In September 2022, the American Medical Association issue…
Posted May 21, 2026
Advancing CAR T cell therapy for solid tumors
US NIH Office of the Director · grant
PROJECT SUMMARY/ABSTRACT Chimeric Antigen Receptors (CAR) are engineered receptors that direct the killing activity of T cells to targets of interest and have had dramatic results in the treatment of B cell leukemia. However, the applicatio…
Posted May 21, 2026
Impact of Cannabinoid Across the Lifespan (ICAL)
US National Institute on Drug Abuse · grant
ICAL ANALYTICAL CORE: SUMMARY The NIDA Center of Excellence Impact of Cannabinoids Across the Lifespan (ICAL), whose renewal is proposed in this revised application, tests the hypothesis that non-physiological activation of the endocannabin…
Posted May 21, 2026
Advancing Wakefulness Screening of Sleep Apnea Disorder through Breathing Sound Analysis and Hardware Optimization
US National Institute of Biomedical Imaging and Bioengineering · grant
Project Summary/Abstract Sleep apnea affects over one billion people worldwide, with obstructive sleep apnea (OSA) accounting for more than 85% of cases. OSA is characterized by repeated episodes of airway obstruction during sleep, leading …
Posted May 21, 2026
Cellular Plasticity and equilibrium in GBM Progression
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY To advance our understanding of therapeutic resistance in Glioblastoma (GBM), it is essential to characterize the individual cell during therapy those fuel tumor recurrence in GBM. However, it is challenging to study the GBM…
Posted May 21, 2026
A Phase 1 Adaptive Dose Escalation Study of Mycophenolate Mofetil in Combination with Temozolomide for Patients with Newly Diagnosed Glioblastoma
US National Cancer Institute · grant
PROJECT 4: PROJECT SUMMARY Glioblastoma (GBM), a grade IV tumor, is one of the most aggressive and infiltrative brain cancer forms. Patients currently diagnosed with Glioblastoma (GBM) have an abysmal prognosis. The median survival is aroun…
Posted May 21, 2026
Improving Outcomes in Veterans with Heart Failure and Chronic Kidney Disease
US Veterans Affairs · grant
Project Summary Heart failure (HF) is a major public health problem with high mortality (~50% at 5 years) and hospital readmission (~25% at 30 days). Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) …
Posted May 21, 2026
Investigating the role of anterior lateral motor cortex in control and execution of sequenced behaviors
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY/ ABSTRACT Although smoothly linking individual actions into sequences is critical for execution of complex behaviors, we still have a limited understanding of how behavioral sequences are encoded in the brain. Accumulating e…
Posted May 21, 2026
OPTIMUM OB-TXA: Optimal TIMing, route and dose of tranexamic acid prior to UMbilical cord clamp for postpartum hemorrhage prevention
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Project Summary The primary goal of this proposal is to fill critical gaps related to timing, route and dose of tranexamic acid (TXA) in prevention of postpartum hemorrhage (PPH) to maximize maternal benefit while minimizing fetal-neonatal …
Posted May 21, 2026