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Showing 25 / 20086 · page 59/804
Selective N-alkylation of azoles via anion-binding catalysis
US National Institute of General Medical Sciences · grant
Project Summary Azoles are ubiquitous amongst bioactive molecules, present in approximately one third of commercial pharmaceuticals. However, selective preparation of N-alkylated azoles is an outstanding synthetic challenge. As a result, st…
Posted May 21, 2026
Summer Research Experience Programs (R25)
US National Institute of Environmental Health Sciences · grant
PROJECT SUMMARY This is a competitive renewal application for continued support of the Rutgers Summer Undergraduate Research Fellowship (SURF) program. The SURF program provides undergraduates with 10-week basic science and translational ha…
Posted May 21, 2026
Training in Environmental Toxicology
US National Institute of Environmental Health Sciences · grant
The Joint Graduate Program in Toxicology (JGPT) is an interdepartmental training program in mechanistic toxicology at Rutgers University. Founded in 1981, the JGPT has trained more than 200 doctoral students, postdoctoral fellows, and clini…
Posted May 21, 2026
Integrated Transporter Elucidation Center
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
PROJECT SUMMARY/ABSTRACT Given their physiochemical properties, medications and dietary supplements often require active transport using solute carriers (SLC) and ATP-binding cassette (ABC) transporters to cross trophoblast barriers. These …
Posted May 21, 2026
The Role of Hypothalamic Dysfunction in Accelerating Aging in Humans
US National Institute on Aging · grant
The Role of Hypothalamic Dysfunction in Accelerating Human Aging Sandra Aleksic, MD, M.S. Mentor: Sofiya Milman, MD, M.S. Co-mentors: Michael Lipton, MD, PhD; Joe Verghese, MBBS, MS Abstract: Mechanisms underpinning biological aging in hum…
Posted May 21, 2026
SC Biomedical Informatics & Data Science for Health Impact (SC BIDS4Health)
US National Library of Medicine · grant
The South Carolina Biomedical Informatics & Data Science for Health Impact (SC BIDS4Health) training program seeks to train informaticists and data scientists to address population-level variations in health outcomes, observed in SC as a mo…
Posted May 21, 2026
Personalized Closed-loop Theta Burst Stimulation for Treatment of Depression
US · IL NIH · grant
PROJECT SUMMARY Depressive disorders are increasingly prevalent in modern societies. Clinical depression is the leading cause of disability worldwide and an underlying condition for two-thirds of suicidal attempts in the United States. Prec…
Posted May 21, 2026
Role of Proteasome Overload in Pathogenesis of Retinitis Pigmentosa
US National Eye Institute · grant
PROJECT SUMMARY / ABSTRACT Retinitis pigmentosa (RP) is the most common hereditary cause of blindness, affecting over 1.5 million people worldwide. RP has an extraordinarily variable etiology, with over 5,000 distinct mutations in more tha…
Posted May 21, 2026
Minnesota Postbaccalaureate Research Education Program in Diabetes, Endocrinology and Metabolic Diseases
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
MN PRIDE is a unique postbaccalaureate program for diverse college graduates, offering a two-year intensive research experience combined with advanced graduate courses. Leveraging UMN's extensive research expertise in Diabetes, Endocrinolog…
Posted May 21, 2026
Placental Insulin Signaling and mTOR Nutrient-Sensing Programming of Offspring Metabolic Health
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Modified Project Summary/Abstract Section Both genetic and environmental factors contribute to the development of Type 2 diabetes (T2D). Hyperinsulinemia is commonly seen among pregnant women with prediabetes, obesity, and gestational diab…
Posted May 21, 2026
Role of Tregs in the acquisition and maintenance of Tconv anergy in transplantation tolerance
US National Institute of Allergy and Infectious Diseases · grant
Summary Donor-specific transplantation tolerance is an important goal for improving the quality of life of transplant patients, as it eliminates side-effects from chronic immunosuppression. Transient regimens that use a blocking CD154 ant…
Posted May 21, 2026
Infections and the Stability of Transplantation Tolerance
US National Institute of Allergy and Infectious Diseases · grant
Overall Summary Transplantation tolerance, a state of hyporesponsiveness to donor antigens after cessation of therapy, is an attractive approach for achieving life-long graft acceptance without global immunosuppression. Tolerance is rare in…
Posted May 21, 2026
Core C -Centralized Laboratory Support Core
US National Institute of Allergy and Infectious Diseases · grant
Core C: Project Summary/Abstract: A major focus of the UCLA-CDU Center for AIDS Research (CFAR) is facilitation of multidisciplinary science to advance research in HIV prevention, treatment, and ART-free remission. The Centralized Laborator…
Posted May 21, 2026
International Maternal, Adolescent and Pediatric Therapeutics Clinical Trials Network
US National Institute of Allergy and Infectious Diseases · grant
ABSTRACT The International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network has significantly advanced efforts to stem the global HIV epidemic among pregnant women, infants, children and adolescents through the conduct o…
Posted May 21, 2026
AIDS Clinical Trial Group Laboratory Center
US National Institute of Allergy and Infectious Diseases · grant
ABSTRACT The AIDS Clinical Trials Group (ACTG) has been at the forefront of clinical research to advance HIV therapeutics and improve the health of patients living with HIV/AIDS for over 30 years. Rigorous scientific research conducted by t…
Posted May 21, 2026
Research Education Core
US National Institute on Aging · grant
ASCENT: RESEARCH EDUCATION CORE (REC) PROJECT SUMMARY/ABSTRACT A lack of trained palliative care scientists is cited as a major impediment to the conduct of quality research focused on the needs of persons living with serious illness and …
Posted May 21, 2026
Hospice Visit Patterns for People with Dementia: Variation, Outcomes, and Policy Considerations
US National Institute on Aging · grant
People with dementia (PWD) make up more than half of the 1.7 million Medicare beneficiaries who receive hospice care each year and represent the fastest-growing group of hospice enrollees. Yet when the Medicare Hospice Benefit began in 1983…
Posted May 21, 2026
Cortical Alpha-Synuclein in Dementia
US National Institute of Neurological Disorders and Stroke · grant
Abstract Lewy-Body dementias, including Parkinson’s disease Dementia and Dementia with Lewy Bodies, are devastating, multi-system diseases and a major cause of dementia worldwide. Patients have characteristic symptoms that suggest dysfuncti…
Posted May 21, 2026
Protein co-pathologies in Alzheimer's Disease and Related Dementias
US National Institute on Aging · grant
Abstract Dementia is associated with staggering economic, social, and personnel costs. Strikingly, most dementia cases have co-pathologies beyond the dominant type. Research suggests these non-dominant protein aggregates can impact cognitio…
Posted May 21, 2026
Accelerating discovery of narrow-spectrum antibiotics for Lyme disease
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY The development of narrow-spectrum antibiotics against the Lyme disease-causing bacterium, Borrelia burgdorferi has the potential to significantly alter current approaches to the treatment and prevention of Lyme disease. Nar…
Posted May 21, 2026
Addressing racial disparities in lung cancer screening
US National Cancer Institute · grant
PROJECT SUMMARY/ABSTRACT Screening promotes early detection of cancer to decrease mortality. Unfortunately, significant racial disparities exist in lung cancer screening. Recently published findings by our team show that under current natio…
Posted May 21, 2026
Incorporating residential histories into assessment of cancer risk
US National Cancer Institute · grant
There is growing recognition that area-level biological and physical exposures associated with residential location across the life-course must be considered for more precise cancer risk and outcomes. Yet many cohort studies lack comprehens…
Posted May 21, 2026
Development of small-molecule autophagy modulators
US National Cancer Institute · grant
Autophagy has been implicated in numerous diseases, including many cancers, but the difficulty of selectively targeting this pathway has presented major challenges for therapeutic development. My laboratory aims to discover novel autophagy …
Posted May 21, 2026
Personalized Therapies of Pediatric Sepsis
US National Institute of Allergy and Infectious Diseases · grant
PROJECT ABSTRACT Sepsis is a life-threatening condition characterized by a dysregulated response to infection, leading to significant organ dysfunction and affecting 75,000 children and one million adults each year. The estimated yearly imp…
Posted May 21, 2026
Pre- and Postnatal Exposure to Air Pollutants and the Gut Microbiome: Implications for Brain Development in Early and Mid-Childhood
US National Institute of Environmental Health Sciences · grant
ABSTRACT Early life exposure to air pollution (AP), which disproportionately affects underserved communities, is thought to disrupt cognitive, emotional, and behavioral development. Human studies show that exposure during the prenatal and e…
Posted May 21, 2026