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Showing 25 / 20086 · page 62/804
EDGE CMT: Identifying genes that shape complex multigenic traits within and between yeast species
US National Human Genome Research Institute · grant
Most phenotypic traits, including nearly all morphological, physiological, and molecular quantities, vary continuously among individuals in a population. These traits are shaped by DNA variation at dozens to thousands of genes, giving them …
Posted May 21, 2026
Causes and consequences of regulatory genetic variation
US National Institute of General Medical Sciences · grant
Project Summary / Abstract Genetic variation among individuals shapes important phenotypes, including the risk for common human diseases such as cardiovascular, autoimmune, and neurological disease. In particular, regulatory genetic variati…
Posted May 21, 2026
PRE-DETERMINE: Advancing Sudden Arrhythmic Death Prediction in Coronary Artery Disease in the Absence of Severe Systolic Dysfunction
US National Heart Lung and Blood Institute · grant
Sudden and/or arrhythmic death (SAD), which typically results from lethal ventricular arrhythmias (ventricular tachycardia and ventricular fibrillation, VT/VF) in the setting of coronary heart disease (CHD), afflicts an estimated 310,000 pe…
Posted May 21, 2026
Barber and Pharmacist Coordination to Improve Blood Pressure Management
US National Institute on Minority Health and Health Disparities · grant
Hypertension (HTN) is a major risk factor for multiple morbid conditions. During the first grant period, our team successfully conducted a cluster-randomized trial of a community-centered blood pressure (BP) reduction program of 319 non-His…
Posted May 21, 2026
Harnessing Diverse Bioinformatic Approaches To Repurpose Drugs For Alzheimers Disease And Related Dementias
US National Institute on Aging · grant
Abstract The exploration of genomes, transcriptomes, and proteomes derived from brains with Alzheimer's disease (AD) by powerful computational tools has developed new knowledge, including the identification of pathways and targets that may …
Posted May 21, 2026
Defining the pathogenic relationship of TDP-43 inclusions and cytoplasmic double stranded RNA in AD and FTD
US National Institute on Aging · grant
Abstract Cytoplasmic inclusions of TDP-43 (TAR DNA-binding protein 43) are found in many patients with Alzheimer's disease (AD). The presence of TDP-43 inclusions predicts a steeper cognitive decline after controlling for other pathologies.…
Posted May 21, 2026
Sex-dependent regulation of social reward by oxytocin in the mesolimbic reward circuitry
US National Institute of Mental Health · grant
PROJECT SUMMARY The rewarding properties of social interactions are critical to the expression of adaptive social behavior and to the development and maintenance of social relationships. Little is known, however, about the factors that dete…
Posted May 21, 2026
PRECISE (PeRfusion imaging to identify postErior CIrculation candidateS for thrombectomy)
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY . Acute ischemic stroke is the leading cause of disability in the United States and the second-leading cause of death worldwide. AIS that involves a major cervical or cerebral artery is termed a large vessel occlusion, and r…
Posted May 21, 2026
Flow Cytometry Core
US National Institute of General Medical Sciences · grant
The Oklahoma Medical Research Foundation has had an operating Flow Cytometry Core for more than thirty years. It has provided multiple investigators in the areas of Immunology, Cell Cycle, Cardiovascular Biology and Developmental Biology wi…
Posted May 21, 2026
Gene Expression in Long-Term Memory
US National Institute of Mental Health · grant
Project Summary Memories are essential for survival and contribute to numerous brain functions. The storage of long-term memories takes time: newly formed memories are initially labile, but over time stabilize and strengthen through a proce…
Posted May 21, 2026
Longitudinal validation of retinal biomarkers against cerebral imaging in preclinical Alzheimer's disease
US National Institute on Aging · grant
Project Summary/Abstract Alzheimer’s disease (AD) is a gradually progressive neurodegenerative disorder that results in total cognitive and functional loss. To date, disease-modifying therapeutics and secondary prevention efforts have prove…
Posted May 21, 2026
Integrating imaging and multi-omics data to infer single-cell 3D genome structures
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY/ABSTRACT The three-dimensional organization of eukaryotic genomes plays a crucial role in transcriptional regulation and cellular functions. However, current genome structure models, primarily derived from genomic data, have…
Posted May 21, 2026
Sex-based differences of a high fat diet in Alzheimer's disease (AD): Can nilotinib reverse bioenergetic and neuropathological deficits?
US National Institute of Neurological Disorders and Stroke · grant
ABSTRACT Metabolic disorders (i.e. obesity, prediabetes or type 2 diabetes), often resulting from poor diet, is a significant risk factor for Alzheimer’s disease (AD). Several common neurodegenerative mechanisms in these two conditions have…
Posted May 21, 2026
Hypertensive Toads: Investigating the Physiological and Evolutionary Pathways to Salt Tolerance in Amphibians
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY My lab focuses on understanding the evolutionary and physiological mechanisms that enable salt-sensitive freshwater organisms, such as anuran amphibians, to develop resilience in saline environments. Chronic exposure to elev…
Posted May 21, 2026
Control of gene expression by dynamic metabolic oscillations
US National Institute of General Medical Sciences · grant
Summary Emerging evidence shows that changes in cellular metabolism can induce broad shifts in gene expression, but the mechanisms underlying this connection are not fully understood. Previous work has not examined the impact of temporal dy…
Posted May 21, 2026
Modeling extensive cellular variability in glycolytic rates using multiplexed live-cell data
US National Cancer Institute · grant
Summary Glycolysis, the fundamental metabolic process in which glucose is converted to lactate, lies at the core of diabetes and metabolic dysfunction, as well as cancer and immune function. Regulation of glycolytic rate by insulin and othe…
Posted May 21, 2026
Understanding the neuronal mechanisms of closed-loop olfaction
US National Institute on Deafness and Other Communication Disorders · grant
Project Summary In nature, sensory perception and motor processing operate in closed-loop. Self-generated movements impact sensory input, and sensory inputs guide future motor commands. Through experience, the brain may learn the reciprocal…
Posted May 21, 2026
Project 3: Albayram
US National Institute of General Medical Sciences · grant
PROJECT 3 – PROJECT SUMMARY Aberrant secondary immune activity after brain injury during neonatal life affects critical phases of brain development, with long-lasting behavioral abnormalities relevant to neurodevelopmental disorders. The mo…
Posted May 21, 2026
Contribution of Nutrient Delivery Rate to Gut-Brain Axis Signaling in Obesity and Bariatric Surgery
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY/ABSTRACT Mechanisms underlying sustained weight loss after bariatric surgery remain unclear, though rapid nutrient delivery is a major candidate driving decreases in caloric intake via the gut-brain axis. Preclinical models …
Posted May 21, 2026
Delineating developmental windows of vulnerability for cannabis exposure and assessing for causal relations between cannabis use, neurodevelopment, and behavior
US National Institute on Drug Abuse · grant
With the ongoing trend of cannabis legalization in the United States and across the world, there is a critical need to better understand links between cannabis use, brain development, and cognitive-behavioral outcomes. Despite growing publi…
Posted May 21, 2026
A Synaptic Basis for Dopamine-Driven Reinforcement Learning in Cortex
US National Institute of Neurological Disorders and Stroke · grant
Project Abstract How the brain reinforces neural activity to drive learning is a fundamental question in neuroscience. Dopamine is a critical neuromodulator that shapes neural circuits during reinforcement learning by modifying synaptic co…
Posted May 21, 2026
The Ecology of Health Knowledge in the United States
US National Institute of Mental Health · grant
An individual’s health decisions and knowledge stem from the norms of family, peers, and communities; media sources; and federal, state, and local policy. Many of these factors stem from a historical evolution and regional idiosyncrasies, i…
Posted May 21, 2026
Enhancing Sleep Spindle Activity through Thalamic TI-TES: Neuromodulatory Foundations for Targeting Thalamocortical Dysfunction in Schizophrenia
US National Institute of Mental Health · grant
PROJECT SUMMARY Sleep spindle deficits are a promising biomarker and therapeutic target for schizophrenia spectrum disor- der (SSD), as they reflect underlying dysfunction in thalamocortical circuits. However, current non-invasive neuromod…
Posted May 21, 2026
Animal Models Shared Resource
US National Cancer Institute · grant
ANIMAL MODELS SHARED RESOURCE: PROJECT SUMMARY Animal models are powerful tools that are vital to translational cancer research. The Georgetown Lombardi Comprehensive Cancer Center (LCCC) Animal Models Shared Resource (AMSR), directed by Ch…
Posted May 21, 2026
Towards a harm reduction approach to perinatal cannabis use
US National Institute on Drug Abuse · grant
PROJECT SUMMARY/ABSTRACT In the United States (US), it is recommended to not use cannabis during pregnancy or while breastfeeding (referred to as “perinatal cannabis use”) because use during pregnancy has been associated with negative paren…
Posted May 21, 2026